Last update 21 Nov 2024

TARLATAMAB-DLLE

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms
Tarlatamab
+ [1]
Mechanism
CD3 inhibitors(T cell surface glycoprotein CD3 inhibitors), DLL3 inhibitors(Delta-like protein 3 inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (EU), Priority Review (US), Accelerated Approval (US)
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Extensive stage Small Cell Lung Cancer
US
16 May 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Extensive stage Small Cell Lung CancerPhase 3
HU
03 Jun 2024
Extensive stage Small Cell Lung CancerPhase 3
HK
03 Jun 2024
Extensive stage Small Cell Lung CancerPhase 3
CZ
03 Jun 2024
Extensive stage Small Cell Lung CancerPhase 3
IT
03 Jun 2024
Small Cell Lung CancerPhase 3
GB
17 May 2023
Small Cell Lung CancerPhase 3
SG
17 May 2023
Small Cell Lung CancerPhase 3
MY
17 May 2023
Small Cell Lung CancerPhase 3
SG
17 May 2023
Small Cell Lung CancerPhase 3
MY
17 May 2023
Small Cell Lung CancerPhase 3
GB
17 May 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
186
(wvlzodalbo) = qexcmazkcm gwnqjwqbun (polnmbkfjk, 30.7 - 50.7)
Positive
09 Sep 2024
Tarlatamab 100 mg
(wvlzodalbo) = nddayhdyoo gwnqjwqbun (polnmbkfjk, 22.6 - 43.1)
Phase 1
88
(ojqwdzkwqw) = None lbhppbvesz (nuamyxtkif )
Positive
09 Sep 2024
Phase 1
40
kufyremavh(ktrrkdzkfd) = 65.0% jazgawuvwd (owzsgxsmhm )
Positive
24 May 2024
Phase 2
Small Cell Lung Cancer
delta-like ligand 3
186
unsjjkphlm(brmtflovxl) = 9.4% and 1.8% oimjpmioqo (rrcscztxpz )
Positive
24 May 2024
Phase 2
99
(rszfzxwgwm) = itiodjzwnh qvioqkpgsj (sdutzxqazd, 31 - 51)
Positive
16 May 2024
Phase 1
152
(joiwztiekm) = No new safety signals were identified fvpckbqvfo (evemioftoa )
Positive
22 Mar 2024
Phase 2
220
(tkyaltzabb) = rixysjxutl fqxdyaxxcj (daopqeqhxu, 29 - 52)
Positive
30 Nov 2023
Tarlatamab 100 mg
(tkyaltzabb) = cfduqctpzj fqxdyaxxcj (daopqeqhxu, 21 - 44)
Phase 2
220
(jhaxxyulea) = waipysukck zcocpcxutf (bfdwdbxykf, 29 - 52)
Positive
20 Oct 2023
Tarlatamab 100 mg
(jhaxxyulea) = kushqwebrm zcocpcxutf (bfdwdbxykf, 21 - 44)
Phase 1
192
(erkjwtisuj) = Safety outcomes were similar in terms of treatment-related AEs (TRAEs; BM, 90%; No BM, 94%) and grade (gr) ≥ 3 (BM, 38%; No BM, 39%) aorgyckwzj (gxiguwsoup )
Positive
31 May 2023
Phase 1
107
(ieinuthxoi) = Any grade treatment-related adverse events (TRAEs) occurred in 97 patients (90.7%) ekipptwnqa (rznkbwfyok )
Positive
23 Jan 2023
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