[Translation] Phase IIa clinical trial of the safety and efficacy of recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) eye drops in the treatment of mild to moderate blepharitis-associated keratoconjunctivitis (BKC)

评估不同剂量rhIL-1Ra 在轻、中度BKC 受试者中的安全性和有效性

[Translation]

To evaluate the safety and efficacy of different doses of rhIL-1Ra in subjects with mild to moderate BKC

Start Date18 Apr 2019

Sponsor / Collaborator

Tibet Huaxi Pharmaceuticals Group Co. Ltd.

NCT03383276 / Unknown statusPhase 1IIT

A Phase 1, Dose Escalating Study of the Safety, Tolerability, and Pharmacokinetics of IL-1-Ra Topically Administered to Eyes of Healthy Adult Subjects

The purpose of this study is to assess the safety and tolerability of ocular administration of Topical Interleukin-1-Receptor Antagonist in healthy volunteers. Additionally, the PK of Interleukin-1-Receptor Antagonist will be assessed.

Start Date18 Dec 2017

Sponsor / Collaborator

Beijing Tongren Hospital

[+1]

100 Clinical Results associated with Blepharokeratoconjunctivitis

100 Translational Medicine associated with Blepharokeratoconjunctivitis

0 Patents (Medical) associated with Blepharokeratoconjunctivitis

Literatures (Medical) associated with Blepharokeratoconjunctivitis

01 Sep 2024·HIV Medicine

Severe ocular Mpox in person living with advanced HIV treated with extended course of tecovirimat

Article

Author: O'Hara, Geraldine ; Douthwaite, Sam ; Brown, Lottie ; Robbie, Scott ; Islam, Meriam ; Downie, Catriona ; Sargent, Pippa ; Kulasegaram, Ranjababu ; Milligan, Iain D. ; Hassan, Ali ; Aarons, Emma

AbstractBackgroundPeople living with HIV are disproportionately represented among people with severe mpox. Mild and self‐limiting conjunctival involvement has been well‐documented, and severe ocular complications, including keratitis, corneal scarring, and the associated loss of vision, are increasingly recognized. Tecovirimat is the first‐line antiviral therapy for severe mpox, but data around the efficacy of systemic antiviral agents for mpox are limited, particularly in cases of ocular mpox.Case ReportHere, we describe a case of sight‐threatening necrotic blepharokeratoconjunctivitis in a person with advanced HIV, requiring an extended course of tecovirimat due to persistent mpox viral shedding for nearly 5 months.

01 Sep 2024·Journal of Pediatric Ophthalmology & Strabismus

Long-term, Low-Dose Oral Azithromycin Treatment for Chronic Severe Bilateral Blepharokeratoconjunctivitis in Pediatric Patients

Article

Author: Ozmen, Ahmet Tuncer ; Akova, Berna ; Baykara, Mehmet ; Yildiz, Meral ; Hasanova, Shole ; Sari, Esin Sogutlu

Purpose:To evaluate the efficacy and safety of oral azithromycin treatment combined with topical antibiotic and anti-inflammatory agents in pediatric patients with chronic severe bilateral blepharokeratoconjunctivitis.Methods:Patients younger than 14 years with chronic and severe bilateral blepharokeratoconjunctivitis were reviewed retrospectively. Consecutive patients receiving oral azithromycin treatment were included. All patients received oral azithromycin (5 mg/kg/single dose daily) for at least 4 weeks combined with topical antibiotic and anti-inflammatory agents. Before and after the treatment, clinical symptoms were noted, and corneal and conjunctival fluorescein staining and corneal neovascularization were graded. Meibomian gland secretion and meibomian gland plugging were also assessed. All patients completed at least 3 months of follow-up after completion of the oral azithromycin treatment. Patients' clinical data at the time of diagnosis and last follow-up visit were statistically compared.Results: Twenty-nine children (58 eyes, mean age of 6.51 years) were included. The mean time of oral azithromycin use was 5.87 weeks (range: 4 to 10 weeks). Clinical symptoms and signs and visual acuity were significantly improved after treatment. The mean fluorescein staining and corneal neovascularization grades and meibomian gland secretion and meibomian gland plugging scores also improved after treatment ( P < .001). Eyelid distortion or fornix shortening was not observed. At the last follow-up visit, all patients were stable with treatment only with daily eyelid hygiene, topical cyclosporine, and artificial tears. Conclusions:Long-term, low-dose oral azithromycin combined with topical antibiotic and anti-inflammatory agents is an effective treatment option for pediatric patients with chronic severe bilateral blepharokeratoconjunctivitis. [ J Pediatr Ophthalmol Strabismus . 2024;61(5):358–364.]

02 Aug 2024·Medicine

Health literacy and its associated factors among the population in two schistosomiasis-endemic villages in Jiangxi Province, China

Article

Author: Xie, Shuying ; Zhang, Jing ; Liu, Kexing ; Zeng, Xiaojun ; Ng, ChiuWan ; Li, Zhaojun

This cross-sectional study aimed to assess the levels of health literacy and the associated factors among the general population living in 2 schistosomiasis-endemic villages in Jiangxi Province, China. Multistage stratified random sampling was used to select participants, and a face-to-face survey was conducted from July to August 2021 to collect participants’ socio-demographic characteristics and levels of overall health literacy (HL) and its 3 subscales: health literacy of basic knowledge and concepts (HL-BKC), health literacy of behavior and lifestyle (HL-BAL), and health literacy of health-related skills (HL-HRS). The Chi-square test and logistic regression models were used to assess the association between socio-demographic characteristics and low HL levels. The prevalence rates of low overall HL, HL-BKC, HL-BAL, and HL-HRS were 84.3%, 61.8%, 82.6%, and 86%, respectively. In addition, no significant differences (P > .05) were noted between the 2 villages regarding overall HL scores and the 3 subscales of health literacy scores. Older age (P < .001), occupation (P < .001), lower educational level (P < .001), and lower annual household income (P < .05) were associated with an increased risk of low HL. Multivariate logistic regression revealed that occupation as a student (OR = 32.289, 95% CI:1.965–530.462, P < .05) and fishermen (OR = 27.902, 95%CI:1.91–407.642, P < .05), lower education level (OR = 0.384, 95%CI:0.149–0.99, P < .05), older age (OR = 5.228, 95%CI:1.458–18.75, P < .001), and lower annual household income (OR = 0.452, 95%CI:0.24–0.851, P < .05) were independently associated with low HL. The prevalence of low HL is high among the population in the schistosomiasis-endemic villages of Jiangxi Province, China. Age, education level, occupation, and annual household income were all independent factors associated with HL levels. Health educational interventions to improve HL should be simultaneously conducted in health promotion work to reduce risky habits.

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