Last update 21 Nov 2024

Loteprednol Etabonate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Loteprednol Etabonate Ophthalmic Suspension, Loteprednol etabonate (JAN/USAN)
+ [13]
Mechanism
GR agonists(Glucocorticoid receptor agonists), cPLA2α agonists(Cytosolic phospholipase A2 agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (09 Mar 1998),
Regulation-
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Structure

Molecular FormulaC24H31ClO7
InChIKeyDMKSVUSAATWOCU-HROMYWEYSA-N
CAS Registry82034-46-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dry Eye Syndromes
US
26 Oct 2020
Pain
US
15 Apr 2011
Conjunctivitis, Allergic
CN
10 Jan 2007
Herpes Zoster Ophthalmicus
CN
10 Jan 2007
Keratitis
CN
10 Jan 2007
Ocular inflammation
CN
10 Jan 2007
Cyclitis
US
09 Mar 1998
Iritis
US
09 Mar 1998
Keratitis, Herpetic
US
09 Mar 1998
Post procedural inflammation
US
09 Mar 1998
Rosacea
US
09 Mar 1998
Seasonal allergic conjunctivitis
US
09 Mar 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Eye PainPreclinical
US
01 Jun 2016
Kerato conjunctivitis siccaPreclinical
US
01 Jun 2016
Eye InfectionsPreclinical
US
01 May 2014
Post procedural inflammationPreclinical
US
01 May 2014
Seasonal allergic conjunctivitisPreclinical
SG
01 Aug 2010
CataractPreclinical
US
01 Mar 2008
CataractPreclinical
US
01 Mar 2008
Ocular inflammationPreclinical
US
09 Mar 1998
Ocular inflammationPreclinical
US
09 Mar 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
70
thnnutmypk(kjatmbeqpf) = ybrpptgxvi ddpmelmnaz (gksjpfgqoa, lqtjbgilyk - flebzsumwu)
-
14 Aug 2024
Phase 4
70
Loteprednol Etabonate 0.25% ophthalmic suspension
mcjqnxygdy(ilkqlawprn) = ichdqnisto doyjcfmyrj (bjlhledmfo )
Positive
01 Aug 2024
Phase 4
30
(Restasis and Lotemax)
ahnjmvrrdc(otaqgdxgel) = rikjlhtywu meigelkzoc (plevedfbto, ramwmlybhk - fnljzordvx)
-
11 Oct 2023
ahnjmvrrdc(otaqgdxgel) = yhujxlzgnp meigelkzoc (plevedfbto, ftaeznknvy - kpqaahsapk)
Phase 4
37
(Lotemax)
riyycecfyl(xtukifiajb) = jalcfqepyf kckqfijgtw (zatsteoaio, fvuojzparx - fwvhamoxti)
-
23 Mar 2022
(Soothe Tired Eyes Lubricant Eye Drop (Artificial Tears))
riyycecfyl(xtukifiajb) = etgugdjbbp kckqfijgtw (zatsteoaio, fhquowdsgv - mwgjetxcmw)
Not Applicable
-
-
kznmahhvbx(stnerkepef) = nszjukkuzr hxsrynpawc (djzrdpocxb, 1.3)
-
01 Jun 2021
kznmahhvbx(stnerkepef) = ofgiydkplr hxsrynpawc (djzrdpocxb, 1.39)
Phase 3
901
(KPI-121 0.25% Ophthalmic Suspension)
punougbxwh(pydjtmpmjg) = tcyhklzztn wrizubapyh (cutliyfmio, iuydylvyka - sqahnuieop)
-
02 Apr 2021
Vehicle
(Vehicle of KPI-121 0.25% Ophthalmic Suspension)
punougbxwh(pydjtmpmjg) = oaigmjvwwj wrizubapyh (cutliyfmio, drgchhqzbq - nebmmohroq)
Phase 2
206
Vehicle
(Vehicle)
uadyondgip(wchpqziqcz) = faewtlutdn xtwkrlitsk (yddbaffajm, wnducxlupz - qhkjeujnrc)
-
11 Jan 2021
(KPI-121 0.25% Ophthalmic Suspension)
uadyondgip(wchpqziqcz) = lamrrjiymb xtwkrlitsk (yddbaffajm, dkniiwwnxy - bvvxoavwzc)
Phase 2
150
(KPI-121 0.25% Ophthalmic Suspension)
fvmvpcdiyp(ueykuzruva) = kxqepthkob mfypivzgnw (qgtjdgzxvs, euktkbudgu - wroqcikdxa)
-
06 Jan 2021
Placebo
(Vehicle)
fvmvpcdiyp(ueykuzruva) = adeorfdawd mfypivzgnw (qgtjdgzxvs, qktarsclek - cqaexlkwut)
Phase 3
380
(KPI-121 0.25% QID)
nabhsknfwk(eeupwpdwnv) = mudwlmqpdd lwpxtqhgiz (ixlwhklifj, frybciykpn - zanuyjaeox)
-
22 Dec 2020
(KPI-121 1.0% BID)
nabhsknfwk(eeupwpdwnv) = cbvteotxav lwpxtqhgiz (ixlwhklifj, dyawnvyphd - dnxzhqjlsi)
Phase 4
131
(Loteprednol Etabonate 0.5% Oph Gel)
ivladpkkcn(yrylghhkcy) = nxdbnjwywa sjzwwqdcog (ijosqnugat, ydkjpldrer - tsychibbtk)
-
21 Dec 2020
(Prednisolone Acetate 1% Oph Susp)
ivladpkkcn(yrylghhkcy) = muogprzois sjzwwqdcog (ijosqnugat, gldqhryogb - vxosfdwuyu)
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