A prospective, multicenter, Phase IV study to evaluate the safety and efficacy of biosimilar cetuximab either alone or in combination with investigator choice chemotherapy/ radiotherapy in patients with locoregionally advanced or recurrent locoregional or metastatic squamous cell carcinoma of the head and neck (SCCHN). - NIL

Start Date05 Sep 2024

Sponsor / Collaborator

Enzene Biosciences Ltd.

[+1]

100 Clinical Results associated with Lip Neoplasms

100 Translational Medicine associated with Lip Neoplasms

0 Patents (Medical) associated with Lip Neoplasms

1,434

Literatures (Medical) associated with Lip Neoplasms

01 Dec 2024·Oral Oncology

Reconstruction of extensive lower lip defects using vascularized mucosal flap with external skin complex tissue

Letter

Author: Wang, Guanru ; Bao, Mingzhe ; Zhang, Gaowei ; Gao, Ning ; Li, Chunjie ; Yan, Bing ; Hua, Yufei ; Paka Lubamba, Grace ; Zhao, Guile ; Lian, Haosen

BACKGROUNDThe complexity of lip anatomy and the roles played by the lip make the reconstruction of lip defects more challenging. Adequate reconstruction of lip defects requires adaptation of mucosa, vermilion, and skin features in lip as well as its specific function.METHODSA 59-year-old male with left lower lip cancer underwent en-bloc resection and left selective neck dissection (SND), followed by immediate reconstruction using Facial Artery Myomucosal Island Flap (FAMMIF) with external Skin Complex Tissue.RESULTSThe use of chimeric flap based on FAMMIF and its external skin tissue allowed minimizing the postoperative problem of combination of both aesthetic and functional impairments. The FAMMIF is suitable for the reconstruction of lip mucosa and lip vermilion, while the external skin tissue can be use to replace the external lip skin defect. The patient was satisfied with the treatment outcomes. He is undergoing follow-up without any evidence of recurrence.CONCLUSIONFAMMIF with external skin complex tissue, as a reconstructive approach selected in our case of lip defect secondary to lip cancer resection, combined the reconstruction of both aesthetics and functions of the lower lip. The technique was found feasible and provided satisfactory postoperative outcomes.

01 Dec 2024·Surgical Oncology

Clinical outcomes of bilobed platysma myocutaneous flap technique with neck dissection in lower lip squamous cell carcinoma

Article

Author: Zhang, Feng ; Eyuboglu, Atilla Adnan ; Akdemir, Ovunc ; Lineaweaver, William

BACKGROUNDSquamous cell carcinoma (SCC) in the lower lip is among the most frequently encountered types of cancer. As the size of this cancer increases, the need for reconstruction becomes evident, posing a significant challenge. Depending on the staging results in these patients, neck dissection may be recommended.OBJECTIVEThis study aims to demonstrate the successful application or feasibility of our Bilobed Platysma Myocutaneous Flap technique in patients with lower lip SCC.METHODSThe Bilobed Platysma Myocutaneous Flap was applied to all patients. Following TNM staging, supraomohyoid and/or radical neck dissection were performed. Surveys were conducted with the patients, and scoring was implemented based on the results for evaluation.RESULTSBetween 2014 and 2018, 23 patients underwent treatment with this flap, and all flaps survived. Among these patients, bilateral supraomohyoid neck dissection was performed on 14, while modified radical neck dissection on one side and supraomohyoid neck dissection on the other side were conducted on the remaining 9 patients. Throughout the 5-year follow-up period, no recurrence was observed in the patients.CONCLUSIONThe combination of the Bilobed Platysma Myocutaneous Flap technique and neck dissection can be successfully employed in the reconstruction and treatment of lower lip cancers.

01 Nov 2024·International Journal of Dermatology

Association of Herpes simplex infection with significantly increased risk of head and neck cancer: real‐world evidence of about 500,000 patients

Article

Author: von Stebut, Jennifer ; Preissner, Saskia ; Rendenbach, Carsten ; Preissner, Robert ; Heiland, Max

AbstractBackgroundThe role of viral agents in the development of head and neck cancers has remained controversial. While markers of viral origin have been isolated from oral cancer tissues, a causative relationship has yet to be shown. The aim of this study was to evaluate the relationship between head and neck cancers and Herpes simplex virus, one of the most common viral infections of the oral orifice.MethodsHere, we conducted a retrospective analysis of two age‐ and gender‐matched cohorts extracted from the real‐world database TriNetX on March 10th, 2023, each consisting of 249,272 patients with and without Herpes simplex infections (ICD‐10: B00). The diagnoses C00‐C14 were analyzed, and risk analysis and Kaplan‐Meier survival statics were computed.ResultsThe strongest association was found for lip cancer (ICD‐10: C00) with a hazard ratio [HR (CI 95% low‐high)] of 3.08 (1.77–5.35). A significant association with HR of 1.17 (1.02–1.34) was found for the entire group of head and neck cancers. Confounders like smoking and alcohol dependence were considered using propensity score matching.ConclusionThe surprisingly strong correlation with lip, oral cavity, and pharynx neoplasms sheds new light on supposedly harmless herpes simplex infections, suggesting them as a possible new factor for risk stratification.

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