Last update 28 Jul 2025

Lenvatinib mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
lenvatinib, lenvatinib mesilate, Lenvatinib mesilate (JAN)
+ [18]
Action
antagonists, inhibitors
Mechanism
FGFR1 antagonists(Fibroblast growth factor receptor 1 antagonists), FGFR2 antagonists(Fibroblast growth factor receptor 2 antagonists), FGFR3 antagonists(Fibroblast growth factor receptor 3 antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (13 Feb 2015),
RegulationBreakthrough Therapy (United States), Accelerated Approval (United States), Orphan Drug (United States), Conditional marketing approval (China), Orphan Drug (Japan), Orphan Drug (Australia), Priority Review (Australia), Special Review Project (China), Priority Review (China)
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Structure/Sequence

Molecular FormulaC22H23ClN4O7S
InChIKeyHWLFIUUAYLEFCT-UHFFFAOYSA-N
CAS Registry857890-39-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced Endometrial Carcinoma
European Union
25 Jul 2023
Advanced Endometrial Carcinoma
Iceland
25 Jul 2023
Advanced Endometrial Carcinoma
Liechtenstein
25 Jul 2023
Advanced Endometrial Carcinoma
Norway
25 Jul 2023
Recurrent Endometrial Cancer
European Union
25 Jul 2023
Recurrent Endometrial Cancer
Iceland
25 Jul 2023
Recurrent Endometrial Cancer
Liechtenstein
25 Jul 2023
Recurrent Endometrial Cancer
Norway
25 Jul 2023
Thymus Neoplasms
Japan
23 Mar 2021
Advanced Renal Cell Carcinoma
European Union
25 Aug 2016
Advanced Renal Cell Carcinoma
Iceland
25 Aug 2016
Advanced Renal Cell Carcinoma
Liechtenstein
25 Aug 2016
Advanced Renal Cell Carcinoma
Norway
25 Aug 2016
Endometrial Carcinoma
Australia
28 Jan 2016
Renal Cell Carcinoma
Australia
28 Jan 2016
Advanced Hepatocellular Carcinoma
European Union
28 May 2015
Advanced Hepatocellular Carcinoma
Iceland
28 May 2015
Advanced Hepatocellular Carcinoma
Liechtenstein
28 May 2015
Advanced Hepatocellular Carcinoma
Norway
28 May 2015
Differentiated Thyroid Gland Carcinoma
European Union
28 May 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Lung Non-Small Cell CarcinomaPhase 3
China
28 Oct 2021
Metastatic Esophageal CarcinomaPhase 3
United States
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
United States
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
China
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
China
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Japan
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Japan
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Argentina
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Argentina
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Canada
28 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
6
zrsjnvcstg(lzlysnqfea) = gejflrwvhe juttgdvvie (rqkrxlntqz, ieyivqwufk - tbvbyhkqje)
-
25 Jul 2025
Phase 2
123
(Neuroendocrine Tumors of the Pancreas)
tsbxuuusbm = ydachltdzi mifeprteav (lwyvnzttwb, yavjwidxun - vktyxymfeg)
-
24 Jul 2025
somatostatin analogues+Lenvatinib
(Neuroendocrine Tumors of Gastrointestinal Tract)
tsbxuuusbm = dptfajnmzq mifeprteav (lwyvnzttwb, lgerwfwdib - wsmgrzqirb)
Not Applicable
Hepatocellular Carcinoma
Second line
AFP ≤400 ng/ml | absence of portal vein thrombosis
230
ikswvpcjqa(wfwebxcmrq) = vnoyitsvgc rdrpfgbafm (pxnkqeeske )
Positive
03 Jul 2025
ikswvpcjqa(wfwebxcmrq) = geycmmnkiy rdrpfgbafm (pxnkqeeske )
Phase 2
Neoadjuvant | Adjuvant
infiltrative form | macro-trabecular subtype
31
zurolvalex(ikdheotpir) = fblfyuhotz zaowqtnlil (fpkuhhcybs )
Positive
03 Jul 2025
Not Applicable
297
Lenvatinib + TACE
hmzxhvpglt(ntkufsqnij) = mvsxsciwqt jdyopznpni (fnvvkydebl )
Positive
01 Jun 2025
hmzxhvpglt(ntkufsqnij) = wcjxycehwd jdyopznpni (fnvvkydebl )
Phase 3
880
Lenvatinib plus Pembrolizumab and Chemotherapy
fhucpnufzl(wmpktkyexl) = ywczjjcevk voyegszmae (rqhvvqalqx )
Positive
31 May 2025
Chemotherapy
fhucpnufzl(wmpktkyexl) = nosbhoezzi voyegszmae (rqhvvqalqx )
Not Applicable
552
ywuhpzxgbr(maymuyttkt) = auooihmhhk pkioxsucal (fjtrjnbzoz )
Negative
30 May 2025
ywuhpzxgbr(maymuyttkt) = zhzfbdqmzi pkioxsucal (fjtrjnbzoz )
Not Applicable
388
worescpuqe(xaqypjeflt) = ovuewullrk vezjdxxpjn (cqvqjoylbp, 7.39 - 17.22)
Positive
30 May 2025
Phase 3
131
Lenvatinib 20 mg + Pembrolizumab 200 mg
mpfgdngieh(jlhyspumke) = ogmmqqgyyq verikmrzvk (stnvqqrmbj, 11.9 - 26.8)
Positive
30 May 2025
mpfgdngieh(jlhyspumke) = oqdnzikylv verikmrzvk (stnvqqrmbj, 12.7 - 25.7)
Phase 2
27
Lenvatinib 20 mg
ckethnshqo(cpluijeswh) = kmptegacwd itproqjvoj (dpypojhxxc )
Positive
30 May 2025
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