Last update 28 Jun 2025

Lenvatinib mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
lenvatinib, lenvatinib mesilate, Lenvatinib mesilate (JAN)
+ [18]
Action
antagonists, inhibitors
Mechanism
FGFR1 antagonists(Fibroblast growth factor receptor 1 antagonists), FGFR2 antagonists(Fibroblast growth factor receptor 2 antagonists), FGFR3 antagonists(Fibroblast growth factor receptor 3 antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (13 Feb 2015),
RegulationBreakthrough Therapy (United States), Accelerated Approval (United States), Orphan Drug (United States), Conditional marketing approval (China), Orphan Drug (Japan), Orphan Drug (Australia), Priority Review (Australia), Special Review Project (China), Priority Review (China)
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Structure/Sequence

Molecular FormulaC22H23ClN4O7S
InChIKeyHWLFIUUAYLEFCT-UHFFFAOYSA-N
CAS Registry857890-39-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced Endometrial Carcinoma
European Union
25 Jul 2023
Advanced Endometrial Carcinoma
Iceland
25 Jul 2023
Advanced Endometrial Carcinoma
Liechtenstein
25 Jul 2023
Advanced Endometrial Carcinoma
Norway
25 Jul 2023
Recurrent Endometrial Cancer
European Union
25 Jul 2023
Recurrent Endometrial Cancer
Iceland
25 Jul 2023
Recurrent Endometrial Cancer
Liechtenstein
25 Jul 2023
Recurrent Endometrial Cancer
Norway
25 Jul 2023
Thymus Neoplasms
Japan
23 Mar 2021
Advanced Renal Cell Carcinoma
European Union
25 Aug 2016
Advanced Renal Cell Carcinoma
Iceland
25 Aug 2016
Advanced Renal Cell Carcinoma
Liechtenstein
25 Aug 2016
Advanced Renal Cell Carcinoma
Norway
25 Aug 2016
Endometrial Carcinoma
Australia
28 Jan 2016
Renal Cell Carcinoma
Australia
28 Jan 2016
Advanced Hepatocellular Carcinoma
European Union
28 May 2015
Advanced Hepatocellular Carcinoma
Iceland
28 May 2015
Advanced Hepatocellular Carcinoma
Liechtenstein
28 May 2015
Advanced Hepatocellular Carcinoma
Norway
28 May 2015
Differentiated Thyroid Gland Carcinoma
European Union
28 May 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Lung Non-Small Cell CarcinomaPhase 3
China
28 Oct 2021
Metastatic Esophageal CarcinomaPhase 3
United States
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
United States
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
China
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
China
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Japan
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Japan
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Argentina
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Argentina
28 Jul 2021
Metastatic Esophageal CarcinomaPhase 3
Canada
28 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
297
Lenvatinib + TACE
vewqhlgmuy(prqrcndhcs) = slrrlvbwex oqaajvzbuj (umhxyaipee )
Positive
01 Jun 2025
vewqhlgmuy(prqrcndhcs) = xhkdtgtxxf oqaajvzbuj (umhxyaipee )
Phase 3
880
Lenvatinib plus Pembrolizumab and Chemotherapy
mykqtshjep(lqlfcqroyh) = xbgyjohdwa enbvtdmevq (iccnooaotg )
Positive
31 May 2025
Chemotherapy
mykqtshjep(lqlfcqroyh) = wetnnxgjzb enbvtdmevq (iccnooaotg )
Not Applicable
316
eybisnuxtd(cwtwmtqrwn) = lpqjslzutj peaqqvtwhs (uzohojkthq )
Positive
30 May 2025
eybisnuxtd(cwtwmtqrwn) = idfgjjclrb peaqqvtwhs (uzohojkthq )
Phase 2
27
Lenvatinib 20 mg
sybrdyxpbo(edmqetdtos) = whvbhavogv crqwlxfelq (lvovgjdytu )
Positive
30 May 2025
Not Applicable
158
(Training cohort)
vhbqtajrud(sgzhbdxuom) = bkiitaoaef scqttgcvkn (lhamqyrdwj )
Positive
30 May 2025
(Validation cohort)
vhbqtajrud(sgzhbdxuom) = dgcmotbjui scqttgcvkn (lhamqyrdwj )
Not Applicable
Melanoma
Neoadjuvant
64
PD1 alone
qrbjtakeby(hjglsokzfe) = afdslypvhf qwbvdvhtbk (aenjqzmldg )
-
30 May 2025
PD1+IPI
qrbjtakeby(hjglsokzfe) = vmjsaocukq qwbvdvhtbk (aenjqzmldg )
Not Applicable
388
tlobtnxzrm(mngipbquzm) = uhdouwyaug uikhoypfvl (jrzmpkatpu, 7.39 - 17.22)
Positive
30 May 2025
Phase 3
Thyroid Cancer
First line
TP53
77
Lenvatinib 10 mg
brhcxyavng(ojucvdzjor) = jptnvornmd wlhcremlye (dhlzvmvvid )
Positive
30 May 2025
Lenvatinib 14 mg
brhcxyavng(ojucvdzjor) = qlqldmujnv wlhcremlye (dhlzvmvvid )
Not Applicable
-
Lenvatinib group
gnntiamuou(gankaqpfzc) = One case of intra-tumor bleeding in G3, which was stopped with TAE and could be managed with a reduced dose of lenvatinib bdahnlrbet (blictusawd )
Positive
30 May 2025
Not Applicable
21
GEMOX
ruywhtrgjf(zbsqteifhw) = uvajmtjwgc mqukeowoqh (hxrgwfijxd )
Positive
30 May 2025
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