Mammary Paget's Disease

5

Clinical Trials associated with Mammary Paget's Disease

ChiCTR2000032336 / CompletedNot ApplicableIIT

IS PREDICTION OF LOCAL RECURRENCE POSSIBLE IN PAGET’S DISEASE OF THE BREAST?

Start Date25 Apr 2020

Sponsor / Collaborator-

ChiCTR1800014979 / RecruitingIIT

A clinical trials of Rapamycin cream in the treatment of pagets disease

Start Date26 Feb 2018

Sponsor / Collaborator-

RBR-3wfshm / Active, not recruitingNot Applicable

Mammillary traumas during breastfeeding and the action of low intensity laser:Randomized Clinical Trial

Start Date03 Jan 2018

Sponsor / Collaborator-

100 Clinical Results associated with Mammary Paget's Disease

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100 Translational Medicine associated with Mammary Paget's Disease

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0 Patents (Medical) associated with Mammary Paget's Disease

491

Literatures (Medical) associated with Mammary Paget's Disease

01 Dec 2024·Radiology Case Reports

Primary nipple melanoma in a patient with breast cancer: A diagnosis to consider

Article

Author: Antonini, Pietro ; Naro, Federica Di ; Giudice, Lucia ; Incardona, Ludovica Anna ; De Giorgi, Vincenzo ; Vidali, Sofia ; Nori, Jacopo ; Vezzosi, Vania ; Nucci, Elena

Melanoma in situ of the nipple is an uncommon diagnosis, with only a few reports in the literature. Due to the variety of pathologies that can affect the nipple-areola complex, the diagnosis can be challenging. In this case report we describe a patient with cosmetic bilateral breast implants who presented with eczema of the left nipple-areola complex and suspicious microcalcifications in the lower inner quadrant of the ipsilateral breast on mammography, subsequently diagnosed with nipple melanoma and concomitant ductal carcinoma in situ.

25 Jul 2024·Cureus

Mammary Paget's Disease Mimicking Benign and Malignant Dermatological Conditions: Clinical Challenges and Diagnostic Considerations

Review

Author: Kołodziej, Faustyna ; NR, Kaushik ; Reza-Soltani, Setareh ; Rezvani, Ali ; Ullah, Muhammad Naqib ; Nr, Kaushik ; Qureshi, Maha R ; Ahmadi, Yasmin ; Scott-Emuakpor, Renee ; Sil-Zavaleta, Susana ; Siddiqui, Humza F ; Nalla, Monica ; Altaf, Sana

Mammary Paget's disease (MPD) or Paget's disease of the breast is a rare dermatological malignancy of the nipple-areolar complex that manifests with a spectrum of symptoms spanning from itching and redness to more severe indications such as breast lump, nipple-areolar complex destruction, or nipple discharge. It is predominantly associated with an underlying ductal carcinoma in situ or invasive ductal carcinoma. MPD often masquerades as other benign and malignant dermatological conditions, including eczema, atopic dermatitis, psoriasis, and squamous and basal cell carcinomas, leading to delayed diagnosis and inappropriate treatment. Only one-third of the patients present with a palpable lump; therefore, advanced age with chronic and unilateral lesions should raise concern for MPD. Our review article presents case reports of MPD imitating other skin conditions and underscores the key findings of clinical features and diagnostic workup to help differentiate the condition. A literature review revealed that studies emphasize caution regarding the sole use of mammography and ultrasound in diagnosing MPD, particularly in cases lacking a palpable lump. This highlights the MRI as a superior and more accurate imaging tool. However, any suspicious lesion must be biopsied to allow histopathological and immunohistochemical examination, since there are some cases where MRI findings were negative in the presence of a biopsy-proven MPD. This highlights the need for clinicians to investigate any suspicious lesion of the nipple or breast using the complete triple assessment approach to exclude an underlying malignancy. It is imperative to establish therapeutic guidelines to approach any nipple lesion to minimize the risk of misdiagnosing any underlying cancer, which can be potentially fatal if left alone.

01 Jul 2024·Cureus

Mammary Paget's Disease Mimicking Benign and Malignant Dermatological Conditions: Clinical Challenges and Diagnostic Considerations.

Review

Author: Kołodziej, Faustyna ; Reza-Soltani, Setareh ; Rezvani, Ali ; Ullah, Muhammad Naqib ; Nr, Kaushik ; Ahmadi, Yasmin ; Qureshi, Maha R ; Scott-Emuakpor, Renee ; Sil-Zavaleta, Susana ; Siddiqui, Humza F ; Nalla, Monica ; Altaf, Sana

Mammary Paget's disease (MPD) or Paget's disease of the breast is a rare dermatological malignancy of the nipple-areolar complex that manifests with a spectrum of symptoms spanning from itching and redness to more severe indications such as breast lump, nipple-areolar complex destruction, or nipple discharge. It is predominantly associated with an underlying ductal carcinoma in situ or invasive ductal carcinoma. MPD often masquerades as other benign and malignant dermatological conditions, including eczema, atopic dermatitis, psoriasis, and squamous and basal cell carcinomas, leading to delayed diagnosis and inappropriate treatment. Only one-third of the patients present with a palpable lump; therefore, advanced age with chronic and unilateral lesions should raise concern for MPD. Our review article presents case reports of MPD imitating other skin conditions and underscores the key findings of clinical features and diagnostic workup to help differentiate the condition. A literature review revealed that studies emphasize caution regarding the sole use of mammography and ultrasound in diagnosing MPD, particularly in cases lacking a palpable lump. This highlights the MRI as a superior and more accurate imaging tool. However, any suspicious lesion must be biopsied to allow histopathological and immunohistochemical examination, since there are some cases where MRI findings were negative in the presence of a biopsy-proven MPD. This highlights the need for clinicians to investigate any suspicious lesion of the nipple or breast using the complete triple assessment approach to exclude an underlying malignancy. It is imperative to establish therapeutic guidelines to approach any nipple lesion to minimize the risk of misdiagnosing any underlying cancer, which can be potentially fatal if left alone.

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