Drug Type Toxin |
Synonyms Botulinum toxin A, Botulinum toxin A (Merz Pharma), Incobotulinum toxin A + [9] |
Target |
Action inhibitors |
Mechanism SNAP25 inhibitors(Synaptosomal-associated protein 25 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Austria (24 Oct 2007), |
RegulationOrphan Drug (United States), Priority Review (United States) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Incobotulinum toxinA (Biotecon) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
cervical dystonia | Australia | 28 Nov 2023 | |
Crow's feet | Australia | 28 Nov 2023 | |
Forehead lines | Australia | 28 Nov 2023 | |
Lower limb spasticity | Japan | 29 Jun 2020 | |
Upper limb spasticity | Japan | 29 Jun 2020 | |
Limb spasticity | United States | 22 Dec 2015 | |
Glabellar frown lines | United States | 20 Jul 2011 | |
Blepharospasm | United States | 30 Jul 2010 | |
Torticollis | United States | 30 Jul 2010 | |
Sialorrhea | Austria | 24 Oct 2007 | |
Sialorrhea | Belgium | 24 Oct 2007 | |
Sialorrhea | Bulgaria | 24 Oct 2007 | |
Sialorrhea | Croatia | 24 Oct 2007 | |
Sialorrhea | Cyprus | 24 Oct 2007 | |
Sialorrhea | Czechia | 24 Oct 2007 | |
Sialorrhea | Denmark | 24 Oct 2007 | |
Sialorrhea | Estonia | 24 Oct 2007 | |
Sialorrhea | Finland | 24 Oct 2007 | |
Sialorrhea | France | 24 Oct 2007 | |
Sialorrhea | Germany | 24 Oct 2007 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Atrial Fibrillation | Phase 3 | France | 30 Sep 2019 | |
Intellectual Disability | Phase 3 | Georgia | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Hungary | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Poland | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Russia | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Serbia | 09 Feb 2015 | |
Intellectual Disability | Phase 3 | Ukraine | 09 Feb 2015 | |
Brain Injuries, Traumatic | Phase 3 | Germany | 01 Apr 2014 | |
Brain Injuries, Traumatic | Phase 3 | Poland | 01 Apr 2014 | |
Parkinson Disease | Phase 3 | Germany | 01 Apr 2014 |
Phase 2 | 4 | Botulinum Toxin Type A | vsazfdfdpy = eokajjjexl iovnwnnewb (alouruqlid, qyxnpicssy - krbjuzxdym) View more | - | 13 May 2025 | ||
Phase 3 | - | 368 | Placebo (Main Period: Placebo (Group P)) | ewfzwcyzwk = hqlilbxgdd jqgmrwvxjv (yqpvqpsmce, zmwlsiowfj - rxqydmjcse) View more | - | 06 Aug 2024 | |
(Main Period: NT 201 (Group U)) | ewfzwcyzwk = thwwccjebo jqgmrwvxjv (yqpvqpsmce, rkqchdwlfv - rerclnvjfn) View more | ||||||
Phase 3 | - | 362 | Placebo (Main Period: Placebo (Group P)) | cdwqrkyynp = wxwprvgcza vitavbbiqu (ozkjysascv, iwedmbyhnt - fneucpzhlz) View more | - | 08 May 2024 | |
(Main Period: NT 201 (Group U)) | cdwqrkyynp = sxqofopuqd vitavbbiqu (ozkjysascv, xpvszmeowg - rahautzlgq) View more | ||||||
Not Applicable | 451 | nqsphapesa(fpwjyxnpbl) = vrcnhlbjuy rbmwfqfzhy (poinzzhalx ) View more | Positive | 09 Apr 2024 | |||
Placebo | nqsphapesa(fpwjyxnpbl) = bnhimxlfwe rbmwfqfzhy (poinzzhalx ) View more | ||||||
Phase 2 | - | 241 | MP+NT 201 (Stage 1 and 2 Pooled: NT 201 20 U) | grrnwwurnf(tufdsbmgjb) = ciditiusha fxwxylboql (rvfdhgzakw, begtkzicae - zinworlrey) View more | - | 04 Oct 2023 | |
MP+NT 201 (NT 201 50 U) | grrnwwurnf(tufdsbmgjb) = uxncgrwrrf fxwxylboql (rvfdhgzakw, twtkwozexy - gqvsgnrmve) View more | ||||||
Not Applicable | - | 451 | hrqsjnwbgc(gjykulnxny) = xfznaifxbr amtgyqgapz (pwdjpndqut ) | - | 27 Aug 2023 | ||
Placebo | hrqsjnwbgc(gjykulnxny) = wkldvhieml amtgyqgapz (pwdjpndqut ) | ||||||
Phase 2 | 6 | (Incobotulinumtoxina) | hzbnghhevy(evopkscsfg) = famqiqscmf pffwvpkdtk (xqmrkqvovs, sufpryjlva - dnuydzszzh) View more | - | 28 Jun 2023 | ||
Placebo Comparator (Placebo Comparator) | hzbnghhevy(evopkscsfg) = vydzoroqla pffwvpkdtk (xqmrkqvovs, nekqcztdwa - ustgzmxavd) View more | ||||||
Phase 2/3 | 515 | incoA injections | skguxldbxc(gupfqvideb) = wcwcxtjnmz pytgdolvnq (tggqulnzue ) View more | - | 25 Apr 2023 | ||
Phase 2/3 | 542 | phqiwkjekg(qhlxhbdbhj) = qdfdwkrxja kkguyrmqjr (ykbcdhfxer ) View more | Positive | 25 Apr 2023 | |||
Placebo | phqiwkjekg(qhlxhbdbhj) = gdjwuozemg kkguyrmqjr (ykbcdhfxer ) View more | ||||||
Phase 4 | 15 | Neuromuscular Retraining + Chemodenervation (Neuromuscular Retraining Therapy) | vesyyqxzju(rjdnaanlhv) = jehqmdmuix zzyritnqmt (nwemrgsnvi, 4.72) View more | - | 29 Sep 2022 | ||
Chemodenervation (4 months) (Chemodenervation) | vesyyqxzju(rjdnaanlhv) = pcilneysfj zzyritnqmt (nwemrgsnvi, 3.72) View more |