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Last update 08 May 2025

Selenium deficiency

Last update 08 May 2025

Basic Info

Synonyms

SELENIUM DEFICIENCY, Se levels low, Se++ low

+ [14]

Introduction-

Drugs associated with Selenium deficiency

Sodium Selenite

Target-

Mechanism-

Active Org.

Illinois College [+2]

Originator Org.

Fujimoto Pharmaceutical Corp.

Active Indication

Selenium deficiency [+2]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date26 Mar 2019

Clinical Trials associated with Selenium deficiency

NCT06614920

/ RecruitingNot ApplicableIIT

Addressing Food-Insecurity: Plant-Based Food Prescription Program to Improve Health Food Access

Reduce food insecurity by improving plant-based health food consumption, access, health and nutrition literacy and the health of the food-insecure families we serve.

Start Date09 Jan 2025

Sponsor / Collaborator

University of Miami

[+1]

TCTR20250214001

/ CompletedPhase 1IIT

Effectiveness of Selenium Supplement Combined with Exercise on Ankle Brachial Index and Bone Mineral Density

Start Date05 Sep 2024

Sponsor / Collaborator-

NCT06293846

/ RecruitingNot ApplicableIIT

BeFit Toolbox Collaboration: Building Empowerment Through Fitness

This project will identify the causative behavioral factors in low-income African American women leading to sedentarism, a major source of morbidity in HABD communities. Working with our partner, WUCN, we will engage with women in HABD housing to develop and (later) deliver a physical activity education program (BeFit) customized for this population.

Start Date15 Mar 2024

Sponsor / Collaborator

The University of Alabama at Birmingham

100 Clinical Results associated with Selenium deficiency

100 Translational Medicine associated with Selenium deficiency

0 Patents (Medical) associated with Selenium deficiency

2,577

Literatures (Medical) associated with Selenium deficiency

01 Dec 2025·Journal of Clinical Immunology

Pulmonary Aspergillosis and Low HIES Score in a Family with STAT3 N-Terminal Domain Mutation

Article

Author: Casanova, Jean-Laurent ; Saarela, Janna ; Hautala, Timo ; Glumoff, Virpi ; Kuismin, Outi ; Jartti, Airi ; Varjosalo, Markku ; Chen, Zhi ; Keskitalo, Salla ; Tiitto, Leena ; Pikkarainen, Keela ; Yannopoulos, Fredrik ; Lima de Souza, Suiane ; Asano, Takaki ; Seppänen, Mikko R J ; Lappi-Blanco, Elisa ; Kaustio, Meri ; Boisson, Bertrand ; Martelius, Timi

AbstractSignal transducer and activator of transcription 3 (STAT3) plays a key role in leukocytic and non-leukocytic cells. Germ line mutations in STAT3, which are mainly found in the SH2, DNA binding and transactivation domains, can be loss- or gain-of-function (LOF and GOF). STAT3 N-terminal domain (NTD) mutations are rare, and their biological effects remain incompletely understood. We explored the significance of STAT3 NTD p.Trp37* variant in a patient with chronic pulmonary aspergillosis and a low Hyper-IgE syndrome (HIES) score. In cell culture models, the expression of full-length p.Trp37* allele showed shorter STAT3 protein expression suggesting a re-initiation (Met99 or Met143). STAT3 activity using luciferase reporter assay showed a twofold-increased activity of the STAT3 p.Trp37* STAT3 protein compared with WT STAT3 at basal level and upon IL-6 stimulation. In contrast, the activity of the short pTrp37* peptide (amino acids 1 to 37) was amorphic but without dominant negative (DN) effect on transcriptional activity or STAT3 Tyr705 phosphorylation. The proteins initiated at Met99 and Met143 were surprisingly hypermorphic. In carriers’ peripheral blood mononuclear cells (PBMCs), both WT and mutated STAT3 mRNA were equally present and the global amount of STAT3 protein was not significantly reduced. In stimulated heterozygous carriers’ PBMCs, however, STAT3 Tyr705 phosphorylation and Th17 were reduced but not completely abolished. This suggests a DN effect of an unknown product of the p.Trp37* allele. Transcriptomics analysis of PBMCs from the index revealed selectively distinct gene expression. We conclude that heterozygosity for the NTD p.Trp37* STAT3 mutation defines a novel allelic form of STAT3 deficiency, associated with a chronic pulmonary aspergillosis and minor signs of HIES.

01 Jun 2025·Food Chemistry

Bioavailability of selenium and the influence of trace elements in crops grown in selenium-rich areas

Article

Author: Luo, Yingjie ; Zhang, Shixi ; Luo, Kunli ; Han, Yangchun ; Hao, Litao

Trace elements in crops can affect the bioavailability of Se. To investigate the effect of trace element on Se bioavailability, trace element concentrations and Se bioavailability in crops from Se-rich area (Langao County, China) were analyzed using the physiologically-based extraction test (PBET) digestion model. Vegetables (rapes, radishes, and potatoes) had higher concentrations of total and bioavailable Se compared to grains (corn, rice, and sweet potatoes), suggesting they are more effective for Se supplementation. The bioavailability of Se was higher in the intestinal phase than in the gastric phase. Trace elements were positively correlated with the increased bioavailability of Se in corn, potato, and rape. Fe was a key element in increased bioavailability of Se in the gut model. Therefore, trace elements, particularly Fe, in crop can enhance Se bioavailability, suggesting their potential use in Se supplementation. The findings of this study provide valuable insights for dietary interventions to Se deficiencies.

01 May 2025·Food Chemistry

Revealing the impact of organic selenium-enriched Lactiplantibacillus plantarum NML21 on yogurt quality through volatile flavor compounds and untargeted metabolomics

Article

Author: Wang, Ruiyun ; Wang, Pengjie ; Li, Yiheng ; Zhang, Weibing ; Zhang, Yixuan ; Wang, Longlin ; Wen, Pengcheng ; Shi, Chengrui ; Liu, Qinqin ; Zhang, Hao

Effective selenium supplementation strategies are essential for alleviating global selenium deficiency. This study utilized the high‑selenium-tolerant strain Lactiplantibacillus plantarum NML21 to produce selenium-enriched yogurt, successfully converting inorganic Se(IV) into organic selenium, with selenoproteins accounting for 69.52 % of the total selenium content (995.19 ± 68.60 μg/g). Selenium-enriched yogurt exhibited excellent physicochemical properties and antioxidant activity. Volatile flavor analysis identified 36 compounds, with NML21 and SeNML21 significantly enhancing ketone flavors in yogurt, particularly increasing the contents of 2-heptanone and 2,3-pentanedione. Untargeted metabolomics identified 215 non-volatile metabolites, with NML21 and SeNML21 significantly regulating key metabolic pathways, including the phosphotransferase system, ABC transporters, and amino acid biosynthesis, promoting the accumulation of beneficial metabolites. Selenium specifically influenced the biosynthesis pathways of ABC transporters, phenylalanine, tyrosine, and tryptophan. This study demonstrates that NML21 is a promising strain for producing selenium-enriched functional yogurt, offering innovative perspectives for dietary selenium supplementation and functional food development.

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Selenium deficiency

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