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OBJECTIVEHigh-grade spondylolisthesis (HGSL) is a rare condition characterized by a vertebral slippage of more than 50% relative to the inferior adjacent vertebra. Despite the range of surgical techniques available, there is no consensus regarding the optimal management approach for HGSL. Although various interventions are documented in the literature, definitive guidelines remain absent. In this systematic review the authors aimed to provide a comprehensive analysis of the chronological evolution of surgical management strategies for HGSL, along with the clinical and radiographic outcomes and complications, to assist surgeons in selecting the optimal approach for their patients.METHODSPubMed, Ovid MEDLINE, Cochrane, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Scopus were systematically searched for eligible studies published in peer-reviewed journals up until May 2024. Following data extraction, the National Institutes of Health quality assessment tools were used to evaluate the methodological quality of the included studies.RESULTSOf 1798 papers found in the literature, 33 met the inclusion criteria. Eligible articles assessed 463 patients with HGSL. Fifteen papers described the reduction approach, whereas 19 papers described the in situ fusion technique. Most of the reported neurological injuries were associated with reduction techniques, whereas most of the graft failures were associated with Bohlman’s technique. Most patients in both the in situ fusion and the decompression and fusion groups reported good outcomes postoperatively in terms of back pain and leg pain.CONCLUSIONSThe historical progression of HGSL treatment, from the early interventions in 1932 to the techniques used today, has been pivotal in shaping patient outcomes. The authors’ findings have many implications for clinical practice, and they provide a framework for implementing treatment guidelines. The authors underscore the importance of a comprehensive evaluation of the benefits and risks of each surgical approach, with particular emphasis on customizing interventions to accommodate the specific anatomical features of each patient.

01 Apr 2025·Journal of Sport & Exercise Psychology

Development and Validation of the Well-Being in Sport Questionnaire and Sport Well-Being Enhancement Profile: Two Instruments to Measure and Promote Sport-Specific Well-Being

Article

Author: Richardson, Clarissa ; Rose, Seth ; Pickering, Michael ; Hammermeister, Jon ; Burton, Damon ; Grindley, Emma ; Stafford-Son, Julie

Athletes’ overall well-being (WB) often intertwines with their sport WB and vice versa. While holistic WB measures have been explored in nonsport contexts, researchers aim to understand competitive athletes’ WB using psychometrically rigorous assessments. Consequently, two interrelated studies were conducted to develop and validate companion instruments: (a) the Well-Being in Sport Questionnaire to gauge outcome-related sport WB and (b) the Sport Well-Being Enhancement Profile to identify strategies for enhancing sport WB. Following contemporary instrument development recommendations, including item development, content, and factor validity, the instruments underwent exploratory factor analysis, exploratory structural covariance modeling, confirmatory factor analysis, and measurement invariance. By utilizing the Well-Being in Sport Questionnaire and Sport Well-Being Enhancement Profile, coaches, athletes, and practitioners can comprehensively understand athletes’ WB, facilitating strategies for daily enhancement alongside peak sport performance.

01 Apr 2025·Journal of Family Issues

Who can refuse? Attitudes About the Fertility Decisions of Wives and Husbands

Author: Tabor, Jaclyn A. ; Oslawski-Lopez, Jamie

This research explored Americans’ responses to dual questions from the “Constructing the Family II” survey asking if it was “all right” for wives and husbands to refuse to have children with their spouses. We reviewed the data descriptively, demographically using multinomial logistic regression, and qualitatively, investigating subset respondents’ rationales. Most respondents supported or opposed refusal equally, with only about five percent of respondents supporting refusal for one partner but not both. Among subset respondents, qualitative themes varied by refusal type and included Family Considerations , Rights , and Nuclear Family Ideals . Together, the quantitative and qualitative findings suggested that those who supported refusal for both spouses were the most egalitarian; however, these respondents along with those who supported refusal for one partner but not both were also likely to provide dissimilar, and often quite traditionally gendered, rationales. We conclude that despite surface-level egalitarianism, attitudes about fertility decision-making were not free from gendered thinking.

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100 Translational Medicine associated with Illinois College

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Pipeline

Pipeline Snapshot as of 14 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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