Spastic paralysis

PALO ALTO, Calif., Sept. 20, 2022 /PRNewswire/ -- Koji Tanabe of I Peace, Inc. () and a researcher Hiroko Nobuta of the University of California, San Francisco (currently assistant professor at Rutgers University) successfully achieved the direct reprogramming: the direct and rapid transformation of Dermal fibroblasts into Oligodendrocyte precursor cells by inducing four genes into the cells. This research was jointly conducted with Prof. Wernig at Sanford University and Prof. Rowitch at UCSF. The research was published in the online edition of an academic journal "Development" on June 24th. Continue Reading Oligodendrocytes are cells that form myelin around the axons of neurons, which act as insulators surrounding the neurons and accelerate the rate at which electrical signals flow. Abnormalities in oligodendrocytes cause cerebral leukodystrophy. The production of a large number of oligodendrocytes is necessary for understanding its pathology, drug discovery, and transplantation medicine. The conventional method of inducing differentiation of human iPS cells or ES cells into oligodendrocytes is inefficient and requires a long time for differentiation induction. Therefore, it has required high cost for the transplantation medicine and the clarification of the pathology, which hinder the development for early treatment and drug discovery. In addition, transplantation treatment has accompanied with problems such as the possibility of tumor formation due to contamination of undifferentiated cells. In this study, we have successfully transformed dermal cells into oligodendrocyte precursors without undergoing the stem cell state. Surprisingly, oligodendrocyte precursors produced directly from dermal cells finally differentiated into functional oligodendrocytes that wrapped around neurons to form myelin sheaths both in vitro and in vivo mouse brain after transplantation. Furthermore, we successfully reproduced the clinical condition in vitro using oligodendrocyte precursors cells generated from dermal cells of a patient with Pelizaeus-Merzbacher disease (PMD), a type of congenital myelination failure. PMD is a developmental disorder that occurs in children and is caused by an abnormality in the oligodendrocyte specific gene PLP1. It is known that the gene abnormality causes oligodendrocytes to die in the brain during differentiation, which prevents myelination. At present, there is no fundamental treatment for the disease, with only palliative treatment for symptoms such as movement impairment, spastic paralysis, and epilepsy. The direct reprogramming from this study successfully reproduced the pathological condition within a significantly reduced production time, which will surely accelerate drug discovery and development in the future. The oligodendrocyte precursor cells produced in this study have been proven to engraft in the mouse brain after transplantation and wrap around neurons. Therefore, they are expected to be technically applied to transplantation regenerative medicine for other congenital myelination failure disorders and myelinopathy (multiple sclerosis, optic neuromyelitis, etc.) which effective treatments are rare. The link to the article published in the journal Development is as follows: The Rowitch and Wernig labs have declared no financial interest in the company and that the company did not fund the research. Researcher Hiroko Nobuta established a laboratory at Rutgers University in New Jersey in September 2020. She works for drug discovery and regeneration research for myelin diseases using oligodendrocytes created by the direct programming. I Peace, inc. I Peace, inc. globally develops sales of GMP iPS cell and entrusted manufacturing services of medical grade cells. The company was founded in 2015 by Koji Tanabe, a graduate of Professor Shinya Yamanaka's laboratory at Kyoto University and the second author of the paper that reported the successful establishment of the world's first human iPS cell line. Tanabe has been involved in iPS cell research since the early days of its development, and is daily working on innovative technical development to make iPS cells accessible to everyone through I Peace, inc. Our unique technology enables us to produce multiple donor-derived iPS cells in parallel without contamination concerns and to provide a large number of iPS cells at a reasonable price. We support drug discovery and cell medicine development by providing our iPS cell and other cell products as high-quality cell products that meet PMDA and FDA standards to pharmaceutical companies and cell medicine development companies. We are also promoting the production of iPS cells for individuals so that everyone in the world can prepare for the future by possessing his or her own iPS cells. We support pharmaceutical companies and cell medicine development companies so that cell medicine will be within the reach of patients as soon as possible. We aim the soonest prevalence of the regenerative medicine by establishing iPS cell banking services for individuals. I Peace, Inc. Founder・CEO：Koji Tanabe Established：2015 Headquarter：Palo Alto, California, U.S.A. Subsidiary in Japan：I Peace, Ltd., Kyoto iPS cell manufacturing base : Peace Engine Kyoto, Kyoto Website : Media contact：[email protected] SOURCE I Peace, Inc.

Reducing preparation steps to help support patient safety LAKE ZURICH, Ill.--(BUSINESS WIRE)-- Fresenius Kabi announced today the immediate availability in the U.S. of Glycopyrrolate Injection, USP in 0.6 mg per 3 mL Simplist® ready-to-administer prefilled syringes. This press release features multimedia. View the full release here: Fresenius Kabi Glycopyrrolate Injection, USP 0.6 mg per 3 mL Simplist® ready-to-administer prefilled syringe (Photo: Business Wire) Fresenius Kabi Simplist Glycopyrrolate Injection, USP is the most recent manufacturer-prepared product available in the company’s proprietary, ready-to-administer portfolio of Simplist prefilled syringes, which reduce the amount of time nurses spend preparing doses and documenting waste.1 “Fresenius Kabi is focused on helping reduce clinician burden by expanding our ready-to-administer offerings,” said John Ducker, president and CEO of Fresenius Kabi USA. “We’re pleased that our Simplist prefilled syringe portfolio now includes Glycopyrrolate Injection, USP, which will minimize preparation complexity to streamline workflows and help support patient safety in the U.S.” Fresenius Kabi Glycopyrrolate Injection, USP 0.6 mg per 3 mL Simplist prefilled syringe may be administered prior to or concomitantly with Simplist Neostigmine Methylsulfate Injection, USP 3 mg per 3 mL prefilled syringe for reversal of neuromuscular blockade. See package inserts for complete dosage and administration information at . Fresenius Kabi also offers Glycopyrrolate Injection, USP in vials. Fresenius Kabi continues to invest in expanding its suite of ready-to-administer (RTA) offerings to assure pharmacists and nurses have a wide range of prefilled, standard strengths, single-patient delivery systems options — from bags to syringes — that streamline medication management from the pharmacy to the bedside, eliminating steps where errors can occur. Fresenius Kabi Simplist Glycopyrrolate Injection, USP is formulated, filled and packaged in the U.S., and is the newest example of the company’s commitment to investing “More in America.” This effort is focused on providing more supply, more science, more support and more care to its customers and the patients they serve in the U.S. Fresenius Kabi has invested nearly $1 billion to modernize and expand advanced U.S. pharmaceutical production and distribution facilities. To learn more about the Simplist portfolio with pharmacy clinical education support, please visit . INDICATIONS AND USAGE Glycopyrrolate Injection, for intramuscular or intravenous use, is an anticholinergic indicated: in anesthesia (adult and pediatric patients) for reduction of airway or gastric secretions, and volume and acidity of gastric secretions, and blockade of cardiac inhibitory reflexes during induction of anesthesia and intubation. intraoperatively to counteract surgically or drug-induced or vagal reflex associated arrhythmias, and for protection against peripheral muscarinic effects of cholinergic agents. in peptic ulcer (adults) as adjunctive therapy for the treatment of peptic ulcer when rapid anticholinergic effect is desired or oral medication is not tolerated. IMPORTANT SAFETY INFORMATION Do not use Glycopyrrolate Injection 0.6 mg per 3 mL single-dose prefilled syringe to administer a dose of less than 0.1 mg (0.5 mL). Contraindications: Known hypersensitivity to glycopyrrolate or any of its inactive ingredients. Peptic ulcer patients with glaucoma; obstructive uropathy; obstructive disease of the gastrointestinal tract; paralytic ileus, intestinal atony of the elderly or debilitated patient; unstable cardiovascular status in acute hemorrhage; severe ulcerative colitis; toxic megacolon; complicating ulcerative colitis; myasthenia gravis. Warnings and Precautions: Precipitation of Acute Glaucoma: Glycopyrrolate Injection may cause mydriasis and increase intraocular pressure in patients with glaucoma. Advise patients with glaucoma to promptly seek medical care if they experience symptoms of acute angle closure glaucoma. Drowsiness or Blurred Vision: May cause drowsiness or blurred vision. Advise patients not to drive or perform hazardous work until resolved. Heat Prostration: Advise patients to avoid exertion and high environmental temperatures after receiving Glycopyrrolate Injection. Intestinal Obstruction: Diarrhea may be an early symptom of incomplete intestinal obstruction. Avoid use in patients with diarrhea and ileostomy or colostomy. Tachycardia: Increase in heart rate may occur. Use with caution in patients with coronary artery disease, congestive heart failure, cardiac arrhythmias, hypertension, or hyperthyroidism. Adverse Events: Most common adverse reactions are related to anticholinergic pharmacology and may include xerostomia (dry mouth); urinary hesitancy and retention; blurred vision and photophobia due to mydriasis (dilation of the pupil); cycloplegia; increased ocular tension; tachycardia; bradycardia; palpitation; and decreased sweating. To report SUSPECTED ADVERSE REACTIONS, contact Fresenius Kabi USA, LLC at 1-800-551-7176, option 5, or FDA at 1-800-FDA-1088 or . Drug Interactions: Other anticholinergics or drugs with anticholinergic activity: May intensify the antimuscarinic effects and result in an increase in anticholinergic side effects. Potassium Chloride in a Wax Matrix: May increase severity of potassium chloride-induced gastrointestinal lesions. Pediatric Use: Infants, patients with Down’s Syndrome, and pediatric patients with spastic paralysis or brain damage may experience an increased response to anticholinergics, thus increasing the potential for side effects. Large doses may cause hyperexcitability. This Important Safety Information does not include all the information needed to use Simplist Glycopyrrolate Injection, USP safely and effectively. Please see accompanying full prescribing information for Glycopyrrolate Injection, USP. Full prescribing information is also available at . References 1. Fanikos J, Burger M, Canada T. An assessment of currently available i.v. push medication delivery systems. Am J Health Syst Pharm. 2017;74(9): e230-e235. About Fresenius Kabi Fresenius Kabi ( ) is a global health care company that specializes in medicines and technologies for infusion, transfusion, and clinical nutrition. The company’s products and services are used to help care for critically and chronically ill patients. The company’s U.S. headquarters is in Lake Zurich, Illinois. The company’s global headquarters is in Bad Homburg, Germany. To learn about U.S. career opportunities at Fresenius Kabi, visit us at and follow us on LinkedIn.