Last update 01 Nov 2024

Asthenozoospermia

Last update 01 Nov 2024

Basic Info

Synonyms

Astheno Teratozoospermia, Astheno Teratozoospermias, Asthenospermia

+ [13]

Introduction

A condition in which the percentage of motile sperm is abnormally low.

Drugs associated with Asthenozoospermia

STSP-0902

Target

NGF

Mechanism

NGF modulators

Active Org.

Staidson (Beijing) Biopharmaceuticals Co., Ltd.

Originator Org.

Staidson (Beijing) Biopharmaceuticals Co., Ltd.

Active Indication

Neurotrophic keratitis [+2]

Inactive Indication-

Drug Highest PhasePhase 1

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Linggui Yangyuan Paste

Target-

Mechanism-

Active Org.

Xiyuan Hospital of China Academy of Chinese Medical Sciences

Originator Org.

Xiyuan Hospital of China Academy of Chinese Medical Sciences

Active Indication

Asthenozoospermia [+1]

Inactive Indication-

Drug Highest PhaseEarly Phase 1

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Asthenozoospermia

NCT05436080 / Not yet recruitingNot ApplicableIIT

Epididymal Ultrasongraphic Findings in Asthenozoospermic Infertile Men and Correlation With Seminal Parameters and L.Carnitine Level

To evaluate the epididymal findings by U.S and study its correlation with seminal parameters including L.carnitine level in infertile males

Start Date01 Aug 2024

Sponsor / Collaborator

Assiut University

NCT06563713 / RecruitingPhase 1

A Phase 1a, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetic, and Immunogenicity of STSP-0902 in Healthy Subjects

This is a Phase 1a, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of STSP-0902.

Start Date31 Jul 2024

Sponsor / Collaborator

Staidson (Beijing) Biopharmaceuticals Co., Ltd.

IRCT20231123060155N1 / RecruitingPhase 3IIT

Evaluation of the effects of Propolis Supplementation on Semen Parameters, Oxidative Stress Biomarkers, Sperm DNA Fragmentation and the Expression of Long Non-Coding RNA HOTAIR in Infertile Men with Asthenozoospermia

Start Date21 Jun 2024

Sponsor / Collaborator-

100 Clinical Results associated with Asthenozoospermia

100 Translational Medicine associated with Asthenozoospermia

0 Patents (Medical) associated with Asthenozoospermia

1,857

Literatures (Medical) associated with Asthenozoospermia

31 Dec 2024·The Aging Male

Age related semen parameters and ICSI pregnancy outcomes of 8046 men in Turkey over a 9-year period

Article

Author: Cincik, Mehmet ; Valizade, Khayala ; Donmez Cakil, Yaprak ; Selam, Belgin ; Bayram, Hale

The effect of paternal age on fertility remains unclear. This retrospective study aims to examine the impact of male age on semen parameters and the reproductive outcomes of men admitted to an infertility center over a 9-year period. A total of 8046 patients were included in the study. Men were divided into four age groups. The groups were evaluated for semen parameters and reproductive outcome. The 21-30 year group presented lower sperm concentrations in comparison to those aged 31-40 and 41-50, yet shared a similar concentration to those over 50 years of age. Moreover, grades A and B decreased significantly in men aged over 50 years. The highest progressive motility and normozoospermia were observed in the age group 31-40 years while men over 50 years of age had the highest rates of asthenozoospermia and oligoasthenozoospermia. Furthermore, live birth results were reported in 5583 of the patients who underwent intracytoplasmic sperm injection (ICSI) and were found highest between 31-40 years of age. To our knowledge, this is the largest study in Turkey focusing on male age-related semen parameters and ICSI pregnancy outcomes. The study demonstrates that age is a significant factor for semen quality and live birth.

31 Dec 2024·Systems Biology in Reproductive Medicine

In silico approach uncovers the shared genetic landscape of type 2 diabetes mellitus and asthenozoospermia

Article

Author: Liu, Chang ; Sun, Taotao ; Gu, Longjie ; Yuan, Penghui ; Chen, Yinwei

Asthenozoospermia (AZS) is one of the most common types of male infertility. Current evidence revealed that type 2 diabetes mellitus (T2DM) is closely associated with declining semen quality, especially for poor sperm motility. This study aimed to uncover the genetic interrelationships and important biomarkers between AZS and T2DM. Transcriptome data regarding AZS and T2DM were downloaded from the Gene Expression Omnibus (GEO) database. We performed GO and pathway analysis, and protein-protein interaction (PPI) network construction for T2DM-related differentially expressed genes (DMRGs). Moreover, we calculated receiver operator characteristic (ROC) curve and conducted external independent validation. Expression of hub DMRGs was assessed for patients using the qPCR method. MiRNA interaction and immune infiltration were subsequently characterized. A total of 554 overlapping DMRGs were identified between the AZS/T2DM and healthy groups. These overlapping DMRG participated in the DNA damage-, energy metabolism-, and immune-related biological pathways. Module function analysis discovered that the top three PPI modules were tightly correlated with DNA damage-related processes. After external validation in other independent datasets, two hub DMRGs (TBC1D12 and SCG5) were obtained. ROC analysis revealed that TBC1D12 and SCG5 had good diagnostic performance (area under the curve > 0.75). Immune infiltration profile showed that the level of T cell co-stimulation and CD8+_T_cells were negatively related to the hub DMRGs expression. Mirna interaction analysis showed 15 significant hub DMRGs-miRNA interactions. The qPCR results showed that expression of TBC1D12 and SCG5 were significantly different between sperm samples from diabetic patients with AZS and controls. The present study revealed molecular signatures and critical pathways between the AZS and T2DM, and identified two hub DMRGs of TBC1D12 and SCG5. The data would provide novel understandings of shared pathogenic mechanisms in T2DM-associated AZS.

01 Dec 2024·Cellular and Molecular Life Sciences

Tektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella

Article

Author: Wang, Bin-Bin ; Jin, Hui-Juan ; Chen, Su-Ren ; Geng, Xin-Yan ; Xia, Lan

AbstractTektins are microtubule inner proteins (MIPs) and localize at the inside lumen of doublet microtubules (DMTs) of cilia/flagella. TEKTIP1, a newly identified protein by cryo-electron microscopy (cryo-EM), is proposed to be localized at the center of the tektin bundle and hypothesized to recruit tektins or stabilize the bundle. However, the physiological role of TEKTIP1 is unknown. In this study, we generated Tektip1-knockout (Tektip1−/−) mice and showed that they were male subfertile primarily due to reduced sperm motility. A high percentage of sperm from Tektip1−/− mice showed moderately disorganized axoneme structures and abnormal flagellar waveforms. TEKTIP1 predominately interacted with TEKT3 among tektins. Loss of TEKTIP1 partially disturbed the organization of tektin bundle by mainly affecting the native status of TEKT3 and its interaction with other tektins. Collectively, our study reveals the physiological role and potential molecular mechanism of TEKTIP1 in axonemal structure and sperm motility, highlights the importance of MIPs in stabilizing DMTs, and suggests a potential relevance of TEKTIP1 deficiency to human asthenospermia. Tektip1−/− mice will be an excellent animal model to study the DMT organization of sperm flagella using cryo-EM in future.

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Asthenozoospermia

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