Development of Padmakadi eye patch and its clinical comparative evaluation with conventional Bidalaka for anti-inflammatory activity in Anterior segment diseases- An open labelled double arm randomised comparative clinical trial. - NIL

Start Date01 Jul 2024

Sponsor / Collaborator

All India Institute of Medical Sciences

CTRI/2024/02/062269 / Not yet recruitingPhase 2/3IIT

A Comparative study on Antimicrobial And Clinical Effectof Trayoshanadi Anjana and itsModulated Ointment Form In EOIM ( ExternalOcular Infection Management ) wsr(with special reference) toBacterial Conjunctivitis - NIL

Start Date12 Feb 2024

Sponsor / Collaborator-

CTRI/2023/08/056217 / Not yet recruitingPhase 2/3IIT

Efficacy of Dhatriadi Eye Drop, Shigrupatradi Eye Drop with Triphaladi Churna in the management of Amaja Abhishyanda (Acute Infective Conjunctivitis)- An open labelled randomized clinical trial. - NIL

Start Date01 Nov 2023

Sponsor / Collaborator-

100 Clinical Results associated with Acute conjunctivitis

100 Translational Medicine associated with Acute conjunctivitis

0 Patents (Medical) associated with Acute conjunctivitis

367

Literatures (Medical) associated with Acute conjunctivitis

01 Oct 2024·Journal Français d'Ophtalmologie

Acute unilateral conjunctivitis as first manifestation of monkeypox viral infection after the 2023 vaccination campaign

Letter

Author: Gil, M A ; Lázaro-Rodríguez, V ; Caminal-Caramés, M ; Conversa, S ; Sabater-Cruz, N ; Saladrigas, A ; Del Campo, Z

01 Sep 2024·Diagnostic Microbiology and Infectious Disease

Establishment of droplet digital PCR for the detection of Neisseria gonorrhoeae

Article

Author: Gao, Ze-Hang ; Zhou, Yu-Lin ; Gu, Bing ; Zhao, Yun-Hu ; Zhou, Yong-Zhuo ; Duan, Chao-Hui ; Chen, Chu-Mao ; Fang, Wei-Zhen ; Guo, Xu-Guang

BACKGROUNDInfection with Neisseria gonorrhoeae in adults usually leads to vaginitis and acute urethritis, and infection through the birth canal in newborns can lead to acute neonatal conjunctivitis. In view of certain factors such as a high missed detection rate of N.gonorrhoeae from staining microscopy method, the time-consuming nature and limited sensitivity of bacterial culture method, complicated and inability of absolute quantification from the ordinary PCR method.METHODSThis study aims to establish a ddPCR system to detect N.gonorrhoeae in a absolute quantification, high specificity, high stability and accurate way. We selected the pgi1 gene as the target gene for the detection of N.gonorrhoeae.RESULTSThe amplification efficiency was good in the ddPCR reaction, and the whole detection process could be completed in 94 min. It has a high sensitivity of up to 5.8 pg/μL. With a high specificity, no positive microdroplets were detected in 9 negative control pathogens in this experiment. In addition, ddPCR detection of N.gonorrhoeae has good repeatability, and the calculated CV is 4.2 %.CONCLUSIONSDdPCR detection technology has the characteristics of absolute quantification, high stability, high specificity and high accuracy of N.gonorrhoeae. It can promote the accuracy of the detecting of N.gonorrhoeae, providing a more scientific basis for clinical diagnosis and treatment.

29 Jul 2024·Cureus

Neisseria meningitidis: The Unforeseen Agent of Acute Neonatal Conjunctivitis

Article

Author: Pelicano, Marta ; Albuquerque, Catarina ; Morais, Rita B ; Dias, Mariana E ; Banganho, Denise

Acute conjunctivitis is a common disease in the neonatal period. Although often underestimated, Neisseria meningitidis is an uncommon but potentially severe cause of acute neonatal conjunctivitis. We describe a case of a 14-day-old healthy female newborn who presented with fever, runny nose, cough, and bilateral purulent ocular discharge. A nasopharyngeal swab tested positive for SARS-CoV-2, and the infant was discharged after becoming afebrile 24 hours later. Four days later, ocular exudate culture revealed the presence of N. meningitidis and Staphylococcus aureus. Blood and cerebrospinal fluid tests were unremarkable. The infant was treated with intravenous cefotaxime and topical azithromycin, with no signs of invasive disease or reported complications. This case highlights noninvasive neonatal acute conjunctivitis caused by a coinfection of N. meningitidis and S. aureus, with a favorable outcome. The ocular exudate culture was crucial in identifying the causative bacteria, which might otherwise have gone undetected and improperly treated. Clinicians should consider N. meningitidis as a potential agent in neonatal acute conjunctivitis.

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