Last update 01 Nov 2024

Paragonimiasis

Last update 01 Nov 2024

Basic Info

Synonyms

DISTOMIASIS, PULMONARY, Endemic haemoptysis, Endemic hemoptysis

+ [47]

Introduction

Infection with TREMATODA of the genus PARAGONIMUS.

Drugs associated with Paragonimiasis

Praziquantel

Target

CYP11B1

Mechanism

CYP11B1 inhibitors

Active Org.

Hunan Er-Kang Pharmaceutical Co., Ltd. [+2]

Originator Org.

Bayer AG

Active Indication

Clonorchiasis [+3]

Inactive Indication

Female genital tract infection [+3]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date29 Dec 1982

100 Clinical Results associated with Paragonimiasis

100 Translational Medicine associated with Paragonimiasis

0 Patents (Medical) associated with Paragonimiasis

848

Literatures (Medical) associated with Paragonimiasis

01 Dec 2024·Food and Waterborne Parasitology

An immunochromatographic test using whole blood for rapid diagnosis of human paragonimiasis and its diagnostic usefulness

Article

Author: Janwan, Penchom ; Boonroumkaew, Patcharaporn ; Intapan, Pewpan M ; Yamasaki, Hiroshi ; Rodpai, Rutchanee ; Maleewong, Wanchai ; Sadaow, Lakkhana ; Sanpool, Oranuch ; Intapan, Pewpan M. ; Thanchomnang, Tongjit

Paragonimiasis is a harmful food-borne zoonosis caused by lung flukes of the genus Paragonimus. The disease is found on most continents, several million people are at risk of infection, and it is a re-emerging disease in developing countries. The gold standard for diagnosis of pulmonary paragonimiasis requires the finding of eggs in sputa and/or fecal samples. In ectopic paragonimiasis cases, eggs are typically not seen, and supportive information is required such as a history of eating freshwater crabs or crayfishes, radiographic findings and immunological tests. Here, we developed a proof of concept based on lateral flow assay, an immunochromatographic test kit, named the paragonimiasis whole-blood test kit, for detection of specific IgG antibody in simulated whole-blood samples (WBSs) using worm excretory-secretory antigens to diagnose human paragonimiasis. The laboratory diagnostic values of this kit were compared with the detected IgG in serum samples. In simulated WBSs, the diagnostic sensitivity and specificity were 97.8 % and 96.1 %, respectively, while for serum samples, these values were 100.0 % and 94.8 %, respectively. The comparative IgG antibody detections whether a result was positive or negative between simulated WBSs and serum samples did not differ significantly with a concordance of 97.8 % in laboratory conditions using a circumscribed set of samples. The tool is fast and easy to use. The next step involves observing and evaluating native whole blood samples and using specific recombinant antigens need to be evaluated for support diagnosis of paragonimiasis caused by P. heterotremus, P. westermani and P. miyazakii at the bedside or at local and remote hospitals with limited facilities. It will also be valuable for epidemiological surveys in Asia where paragonimiasis is endemic.

01 Dec 2024·Diagnostic Microbiology and Infectious Disease

Pleural parasite infection presenting with an isolated pleural effusion misdiagnosed as tuberculosis: a case report

Article

Author: Wang, Nian ; Qi, Ren-Jie ; Yang, Qiu-Shi ; Ruan, Shu-Song

Pleural parasitic infection is an extremely rare disease of the pleura caused by a variety of parasites, with paragonimiasis infection being the most common. The lack of specific clinical symptoms for paragonimiasis makes it easy to misdiagnose as tuberculosis, causing unnecessary drug-related adverse effects and financial burdens from incorrect treatment. We report a case of a pediatric patient presenting with an isolated pleural effusion that was misdiagnosed as tuberculosis; the patient was eventually diagnosed with pleuropulmonary paragonimiasis infection after immunologic and serologic tests. The patient finally recovered after anti-parasitic treatment involving praziquantel administration. This report will help increase awareness of this disease among medical practitioners to avoid misdiagnosis and treatment delays which may lead to disease progression.

01 Jul 2024·Journal of Infection and Chemotherapy

Epidemiologic evaluation of pulmonary paragonimiasis in Japan using a Japanese nationwide administrative database

Article

Author: Ikushima, Issei ; Fujino, Yoshihisa ; Ikegami, Hiroaki ; Yatera, Kazuhiro ; Muramatsu, Keiji ; Matsuda, Shinya ; Mukae, Hiroshi ; Akata, Kentaro ; Fushimi, Kiyohide ; Tahara, Masahiro ; Nishida, Chinatsu ; Nemoto, Kazuki ; Yamasaki, Kei

BACKGROUNDParagonimiasis is a parasitic disease primarily contracted through consumption of undercooked freshwater crustaceans or wild boar meat. Large-scale nationwide epidemiological data on paragonimiasis are lacking. In this study, we aimed to investigate the nationwide epidemiology of hospitalized patients with paragonimiasis in Japan using a comprehensive nationwide Japanese administrative database.METHODSWe evaluated the Japanese Diagnosis Procedure Combination (DPC) data of patients diagnosed with pulmonary paragonimiasis between April 1, 2012 and March 30, 2020. The patients' address and information, including age, sex, treatment (medication: praziquantel; surgery: open thoracotomy or intracranial mass extirpation), Japan coma scale, comorbidities, and length of hospital stay, were extracted.RESULTSOf the 49.6 million hospitalized patients, data were extracted on 73 patients with paragonimiasis, of whom 36 were male and 37 were female. The mean age was 49.7 years and the mean length of stay was 12.5 days. The most frequent comorbidity was pleural effusion (31.5 %), followed by pneumothorax (13.7 %). The sites of ectopic paragonimiasis in organs other than the lung included the liver (5.5 %), skin (4.1 %), and brain (2.7 %). Geographically, most patients were from the Kyushu region (54.8 %), followed by the Kanto region (22.0 %). Fukuoka Prefecture had the highest number of patients (22.0 %) by prefecture. During the study period, an average of 9.1 patients/year were hospitalized with lung paragonimiasis in Japan.CONCLUSIONParagonimiasis has not completely disappeared in Japan; thus, physicians should be aware of paragonimiasis in the Kyushu region, especially in the Fukuoka Prefecture.

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Paragonimiasis

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