Assessment of Combined Antiparasitic Drugs Praziquantel and Albendazole Versus Albendazole Alone in the Treatment of Active Parenchymal Neurocysticercosis in Tanzania and Zambia

The goal of this clinical trial is to compare the combination albendazole and praziquantel versus albendazole alone in patients affected by neurocysticercosis.

Start Date01 Jun 2024

Sponsor / Collaborator

R-Evolution Worldwide S.r.l.

[+5]

PACTR202402599048090 / RecruitingPhase 2

Efficacy and safety of pyronaridine/artesunate and pyronaridine/artesunate/praziquantel for treatment of uncomplicated Schistosoma haematobium infection in Gabonese adolescents and children

Start Date01 Sep 2023

Sponsor / Collaborator-

NCT05354258 / Unknown statusNot ApplicableIIT

Feasibility and Effectiveness of Delivering Mass Drug Administration for Helminths Through the Seasonal Malaria Chemoprevention (SMC) Platform in a West African Paediatric Population

Malaria remains a major health problem, especially in sub-Saharan Africa where more than 90% of the disease and deaths occur in children. Adding to this high burden among the children is the co-existence of intestinal and genito-urinary worms. Prominent among these are soil-transmitted helminths and schistosomiasis. Existing control programmes for the worms are operating below the expected level, despite the commitments and support that followed the 2012 London Declaration of achieving 75% treatment coverage by 2020. On the other hand, a malaria prevention programme, called Seasonal Malaria Chemoprevention (SMC), introduced in the same year 2012 has achieved more than 75% treatment coverage and prevented 75-85% cases of uncomplicated and severe malaria in children. This encouraging development supports the need to explore the strategies involving the integration of worm control with successful platforms such as SMC. This would align worm and malaria control with the WHO road map for Neglected Tropical Diseases (NTD) of ending the neglect to attain Sustainable Development Goals by eradicating diseases of poverty and promoting health and well-being for those at risk. Given this context, it is important to develop a treatment approach that combines malaria and helminth control in an integrated framework that will be safe, effective and easy to deliver. This study will, therefore, investigate the feasibility and effectiveness of co-administration of anthelminthic and SMC drugs in a high-risk paediatric population living in a malaria-helminth co-endemic setting in Senegal, West Africa. This study is designed to test the hypothesis that co-administration of SMC and anthelminthic drugs will be safe and tolerated among children aged 1-14 years and that the incidence of side effects will not be significant. The objectives of this study are to assess the safety, tolerability, and effects of co-administration of SMC and anthelminthic drugs among the children

Start Date16 Jun 2022

Sponsor / Collaborator

London School of Hygiene & Tropical Medicine

100 Clinical Results associated with Praziquantel

100 Translational Medicine associated with Praziquantel

100 Patents (Medical) associated with Praziquantel

5,562

Literatures (Medical) associated with Praziquantel

01 Apr 2024·Parasitology international

Expression profile analysis of the transient receptor potential (TRPM) channel, a possible target of praziquantel in Schistosoma japonicum

Article

Author: Macalanda, Adrian Miki C ; Atcharaphan, Wanlop ; Ona, Kevin Austin L ; Suguta, Saki ; Watanabe, Ken-Ichi ; Kawazu, Shin-Ichiro ; Suganuma, Keisuke ; Ushio, Nanako ; Kirinoki, Masashi ; Inoue, Noboru ; Shinozaki, Kaho ; Ohari, Yuma

The WHO considers schistosomiasis, which is controlled by the mass administration of the drug praziquantel (PZQ), to be a neglected tropical disease. Despite its clinical use for over four decades, PZQ remains the only choice of chemotherapy against this disease. Regarding the previous studies that demonstrated that PZQ activates the transient receptor potential (TRP) channel in Schistosoma mansoni (Sm.TRPM_PZQ), the expression profile of the ortholog of this channel gene (Smp_246790.5) in S. japonicum (EWB00_008853) (Sj.TRPM_PZQ) was analyzed. The relative expression of this gene in various stages of the parasite lifecycle was analyzed by quantitative real-time reverse transcription-PCR (qRT-PCR), and the expression of Sj.TRPM_PZQ was observed by immunohistochemical staining using anti-serum against the recombinant Sj.TRPM_PZQ protein. qRT-PCR revealed the significantly lower mRNA expression in the snail stage in comparison to other stages (p < 0.01). The relative quantity of the Sj.TRPM_PZQ expression for paired females, unpaired males, and eggs was 60%, 56%, and 68%, respectively, in comparison to paired males that showed the highest expression (p < 0.05). Interestingly, immunostaining demonstrated that Sj.TRPM_PZQ is expressed in the parenchyma which contains muscle cells, neuronal cells and tegument cells in adult worms. This may support the two major effects of PZQ-worm paralysis and tegument disruption-induced by channel activation. Moreover, the channel was expressed in both the eggshell and the miracidia inside, but could not be observed in sporocyst. These results suggest that the expression of Sj.TRPM_PQZ corresponds to the known sensitivity of S. japonicum to PZQ.

01 Apr 2024·World neurosurgery

Pseudotumoral Encephalic Schistosomiasis: A Literature Review

Review

Author: Abodief, Wael T ; Yousef, Waleed ; Shabbir, Zafdam ; Jarkhi, Hussain H ; Gad, Khaled ; Ibrahim, Marwa ; Najibullah, Mustafa ; Khan, Tufail ; Azab, Waleed A

Pseudotumoral encephalic schistosomiasis (PES) is the chronic form of cerebral neuroschistosomiasis, and is rarely encountered in clinical practice. Clinically, PES closely resembles other intracranial space-occupying lesions including brain tumors. Laboratory investigations are usually inconclusive, and neuroradiologic findings are frequently reported as non-specific. Such diagnostic difficulties may result in delayed diagnosis and treatment. Across the literature, there is a paucity of information about and controversy over many aspects of the disease. Particularly, inconsistent magnetic resonance imaging (MRI) findings, a wide variation of medical treatment protocols, lacking consensus regarding the indications of surgery, and undetermined information regarding the impact of the extent of resection on prognosis. We herein review the pertinent literature with the aim of providing focused information regarding the pathogenesis of PES, its currently identified more distinctive neuroimaging features, and the indications and extent of surgery in light of the state-of-the-art operative neurosurgical practice. A distinctive multinodular arborizing pattern of PES lesions can often be observed on MRI in patients with PES. Praziquantel is considered by many authors to be the drug of choice in all cases, and seems to be effective at variable dose regimens. Although lesion excision utilizing current technology is generally safe, the indications and extent of surgery are still undetermined and should be decided on a case-by-case basis. Multicenter collaborative research is further needed to fill the existing gaps in the current knowledge on PES.

01 Mar 2024·The Lancet. Infectious diseases

Chronic intestinal schistosomiasis caused by co-infection with Schistosoma intercalatum and Schistosoma mansoni

Review

Author: Krupski, Witold ; Bogucka-Kocka, Anna ; Cichoż-Lach, Halina ; Starownik, Dorota ; Bojar, Paweł ; Kołodziej, Przemysław ; Szostakowska, Beata ; Kocki, Janusz ; Szymańska, Magdalena ; Kasztelan-Szczerbińska, Beata ; Lass, Anna ; Bogucki, Jacek ; Szumiło, Justyna ; Sikorska, Katarzyna ; Fota-Markowska, Hanna ; Sulima, Małgorzata

The Grand Round concerns a 24-year-old man from Zimbabwe who was studying and living in Poland. The patient had been complaining of abdominal pain, fatigue, alternating diarrhoea and constipation, and presence of blood in his stool for 3 years. The patient had the following diagnostic tests: colonoscopy, CT scan, histopathology, and parasitological and molecular tests. Results of the examinations showed that the cause of the patient's complaints was chronic intestinal schistosomiasis due to the co-infection with Schistosoma intercalatum and Schistosoma mansoni. The patient had two cycles of praziquantel therapy (Biltricide) and responded well to the treatment. In the Grand Round, we describe full diagnostics as well as clinical and therapeutic management in the patient with S intercalatum and S mansoni co-infection. This case allows us to draw attention to cases of forgotten chronic tropical diseases (including rare ones) in patients from regions with a high endemic index staying in non-endemic regions of the world for a long time. Co-infection with S intercalatum and S mansoni should be considered as a very rare clinical case.

News (Medical) associated with Praziquantel

05 Jun 2024

·www.sciencedaily.com

Universal bitter blocker could help patients take their medicines as prescribed

Strong bitterness is the main reason why people all over the world, especially children, avoid taking their medicines, putting their health, and sometimes, their lives at risk. Now, a group of scientists has identified the first temporary, universal taste blocker that works in people. Many people, especially children and the elderly, have difficulty swallowing pills. Liquid forms of many medicines taste extremely bitter and are often rejected. Put simply, strong bitterness is the main reason why people all over the world, especially children, avoid taking their medicines, putting their health, and sometimes, their lives at risk. Now, a group of scientists at the Monell Chemical Senses Center identified the first temporary, universal taste blocker that works in people. Their findings appear in the British Journal of Pharmacology. "Remarkably, and unlike our experience with blockers of bitter taste receptors, the taste-nerve blocker we tested worked for every subject and every bitter compound we tested," said first author Linda J. Flammer, PhD, Monell Senior Research Associate and Director of the Corporate Partners Program. "I have never seen this before." Until now, efforts to block bitterness in foods and medicines have focused on finding blockers for bitter taste receptors on the tongue. Because different medications activate distinct sets of bitter taste receptors, targeting specific receptors may only suppress bitterness for certain, but not all, bitter-tasting compounds. "There is a clear need to develop bitter blockers that are able to suppress the bitterness of many medications," said co-author Carol Christensen, PhD, Monell Alumnus Faculty Member. "Although humans have 25 different bitter receptors, our ongoing research suggests only a handful of bitter receptors may be responsible for most of the bitterness of medicines." Taste cells in the mouth that express the TAS2R family of taste receptors are stimulated by sweet, bitter, and savory compounds, and transmit signals to nerve fibers by releasing adenosine triphosphate (ATP), a cell's main source of energy. In turn, ATP activates a receptor called P2X2/P2X3 on the receiving nerve cells. These nerves send information to the brain about the taste of foods and medications. The team used an inhibitor of P2X2/P2X3 receptors, called AF-353, to block taste-nerve transmission and reduce the bitterness signal caused by medications and other taste compounds. Several blockers of P2X2/P2X3 receptors have been identified, with some tested in clinical trials to treat chronic cough; however, a side effect in these trials was taste disturbance. The Monell team capitalized on the "side effect" of these compounds to create an oral treatment that enhances the palatability of medicines. A key finding of the study is that rinsing the mouth with AF-353 significantly reduced the bitterness of two important medicines that treat common chronic diseases: Praziquantel for parasites and Tenofovir Alafenamide (TAF) for hepatitis B and HIV. "AF-353 is the first universal bitter taste blocker that has been identified," said Monell Faculty Member Peihua Jiang, PhD. "In addition to bitter taste, it also affects savory, salt, sweet, and sour tastes. However, AF-353 only blocks taste. Other oral sensations like the tingle from carbonation were not affected." The team conducted both human sensory taste testing and mouse behavioral experiments to determine the breadth, strength, and duration of the blocking effects. The results of the human and rodent studies were similar in the breadth and duration of AF-353's action. The topical application of AF-353 directly into the mouth may improve compliance of many important medications, especially those that are life-saving for children in developing countries. "In people, the blocking effect lasted 60 to 90 minutes, when their taste was restored to normal," said Flammer. "We are now looking for taste blockers that act faster and allow taste to return to normal sooner," said Jiang.orted by the Bill & Melinda Gates Foundation (INV-037008 and INV-042630). The behavioral work was performed at the Monell Behavioral and Physiological Phenotyping Core, which is supported, in part, by the National Institutes of Health (NIH) NIDCD Core Grant 1P30DC011735-01. Research infrastructure was provided in part by NIH Grant G20OD020296.

Clinical Result

02 Apr 2024

·www.fiercepharma.com

Merck KGaA names winner of storytelling competition to boost schistosomiasis awareness in Ethiopia

In addition to supplying praziquantel, Merck KGaA’s four-pronged efforts toward “#MakingSchistoHistory” comprise developing new treatments for the disease, implementing health education and water safety initiatives and forming partnerships to bolster all of that work. After nearly two decades spent working with the World Health Organization (WHO) to supply billions of praziquantel tablets to help treat schistosomiasis, Merck KGaA has recently tacked on an additional awareness-raising component to its efforts to eliminate the parasitic disease also known as bilharzia. That project has been dubbed the Bilharzia Storytelling Lab, and it wrapped up its third iteration late last month, the drugmaker announced Tuesday. The latest lab took place in Ethiopia, following previous installments in Kenya and Rwanda. For this year’s lab, local participants were invited to a five-day workshop in Addis Ababa, during which they learned more about schistosomiasis and received instruction on storytelling from local and international experts. From there, the participants worked with health-focused and other nonprofit organizations to develop storytelling-based solutions that could help raise awareness about the disease in their communities. A panel of judges was tasked with selecting the best solution, which Merck will help implement throughout Ethiopia. The winning solution this year—which was awarded a grand prize of 10,000 euros—uses multimedia participatory theater to improve awareness of schistosomiasis, specifically targeting young men working in sugar factories. “We have seen great pitches today and it wasn’t easy to pick only one. In the end, we decided on Team Buna because it is an innovative and locally applicable solution, which is also scalable to surrounding communities,” Johannes Waltz, head of the Merck Schistosomiasis Elimination Program, said in a statement after judging was complete. The previous two winners included a card game that could educate young children about the disease through play and a school notebook that included information about disease prevention for both children and their caregivers, according to Merck. Schistosomiasis infections occur when the skin is exposed to parasites in bodies of water. After infection, parasite eggs that aren’t passed out of the body may become trapped within tissues, resulting in immune reactions and organ damage, per a WHO fact sheet. The organization has placed schistosomiasis in its group of neglected tropical diseases, as it is especially prevalent in poor communities within tropical and subtropical regions that don’t have ready access to clean water. The WHO estimates that at least 90% of the approximately 250 million people requiring treatment for the disease live in Africa. Since 2007, Merck KGaA has been working with the WHO to distribute praziquantel tablets, the recommended treatment for the disease, with efforts focused mainly on sub-Saharan Africa. Merck said in this week’s announcement that it provides the organization with up to 250 million tablets per year, for a total donation to date of 2 billion tablets, which have been used to treat around 800 million people. In addition to supplying praziquantel, Merck’s four-pronged efforts toward “#MakingSchistoHistory” comprise developing new treatments for the disease, implementing health education and water safety initiatives and forming partnerships to bolster all of that work.

17 Dec 2023

·www.prnewswire.com

EMA Recommends Arpraziquantel for Treatment of Schistosomiasis in Preschool-Aged Children

- Astellas contributed to the development of a pediatric formulation to treat schistosomiasis as a member of the Pediatric Praziquantel Consortium - TOKYO, Dec. 17, 2023 /PRNewswire/ -- Astellas Pharma Inc. (TSE: 4503, President and CEO: Naoki Okamura, "Astellas") contributed to the development of a pediatric formulation to treat schistosomiasis as a member of the Pediatric Praziquantel Consortium (Consortium). The Consortium announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive scientific opinion for arpraziquantel to treat one of the neglected tropical diseases, schistosomiasis, in preschool-aged children (3 months to 6 years of age) on December 15. EMA assessed arpraziquantel under the EU-Medicines for all (EU-M4all) *1 procedure for high-priority medicines intended for use in countries outside the European Union. For more details on arpraziquantel, please refer to the Consortium's press release. Continue Reading Astellas provided its innovative formulation technology to co-develop arpraziquantel as a member of the Consortium. The new pediatric formulation of arpraziquantel is palatable for very young children by reducing the bitter taste associated with the medication and administered via a 150 mg dispersible tablet that is dissolved in water. The prototype of the pediatric formulation has been developed by Astellas and further optimized by Merck (Germany) for global production using simple manufacturing processes yielding tablets that can remain shelf stable, even in hot and humid tropical climates. Farmanguinhos (Brazil) brings expertise in production and distribution and will be the manufacturing site for the future introduction of the new pediatric medication in endemic countries. The partnership with Universal Corporation Ltd. (Kenya) is also supporting the planned future large-scale local production to serve African countries. In parallel with this regulatory work, the Consortium's implementation research program (ADOPT)*2 is ongoing and preparing for the introduction of arpraziquantel in the first endemic countries in Africa. To ensure equitable and sustainable access, it is essential that new procurement and funding mechanisms are collaboratively explored and established. The intent is to make the product available at an at-cost basis in sub-Saharan African countries. Astellas has set a Strategic Goal to "deepen our engagement in sustainability" in the Astellas Corporate Strategic Plan 2021. To address the key sustainability issue of Access to Health (ATH), Astellas uses a comprehensive approach including, (1) Astellas' core business (Rx, Rx+), (2) Enhancing availability of Astellas products (Access to Medicines), and (3) Collaboration and support for the activities implemented by external partners. Initiatives in the Consortium apply to (3), and the positive CHMP scientific opinion by EMA of arpraziquantel represents a significant milestone in alignment with Astellas' Access to Health focus. Naoki Okamura, President and CEO, Astellas "We are so pleased that arpraziquantel received a positive scientific opinion by EMA, and also proud that Astellas could contribute to its development by providing our innovative formulation technologies. Access to Health is essential to the health of people around the world, and we recognize it as a material issue for Astellas. Through our VISION to be "On the forefront of healthcare change to turn innovative science into VALUE for patients", we are proactively taking a comprehensive approach to solving this issue." For more information on Astellas' contribution to the development of arpraziquantel, please see (). About schistosomiasis Schistosomiasis (also known as bilharzia) is one of the most prevalent parasitic diseases worldwide and a very important one in terms of public health burden and economic impact. It is a poverty-related disease that is widespread in tropical and subtropical regions where large sections of the population have no access to clean water. Flatworms transmit the disease and people become infected with the parasite through contact with freshwater, for example, while working, swimming, fishing, or washing their clothes. The minuscule larvae penetrate human skin, enter the blood vessels, and attack internal organs. The infection rate is particularly high among children. Schistosomiasis is a chronic condition and is classified by the World Health Organization (WHO) as one of 20 neglected tropical diseases (NTDs). About Arpraziquantel The current standard of care treatment for schistosomiasis is praziquantel. Praziquantel is safe, effective, and suitable for school-aged children and adults. Extending the range of options for the treatment of schistosomiasis, arpraziquantel is tailored for preschool-aged children against Schistosoma mansoni and Schistosoma haematobium. Tested in clinical development, under the responsibility of Merck, arpraziquantel contains the pharmacologically active enantiomer of praziquantel. In developing arpraziquantel, the Pediatric Praziquantel Consortium established a pediatric drug development program, divided into four major steps: preclinical development, clinical development, registration, and access. All details can be found on the Consortium website. About the Pediatric Praziquantel Consortium The Pediatric Praziquantel Consortium is an international public-private partnership that aims to reduce the global disease burden of schistosomiasis and improve child health by addressing the medical needs of infected preschool-aged children. Its mission is to develop, register, and provide access to a suitable pediatric drug for treating schistosomiasis in children 3 months to 6 years of age. For more information, and to see an overview of all Consortium partners, visit the Consortium website. Consortium Partners Merck (Germany) Astellas Pharma Inc. (Japan) The Swiss Tropical and Public Health Institute (Switzerland) Lygature (The Netherlands) Farmanguinhos (Brazil) Unlimit Health (United Kingdom) Kenya Medical Research Institute (Kenya) Université Félix Houphouët-Boigny (Côte d'Ivoire) Klinikum rechts der Isar der Technischen Universität München (Germany) Ministry of Health Côte d'Ivoire (Côte d'Ivoire) African Institute for Health and Development (Kenya) Other collaborators that contribute to the mission of the Pediatric Praziquantel Consortium: Makerere University School of Public Health (Uganda) Ministry of Health Kenya, Division of Vector Borne and NTDs (Kenya) Ministry of Health Uganda, Vector Borne and NTDs Control Division (Uganda) About Astellas Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are promoting the Focus Area Approach that is designed to identify opportunities for the continuous creation of new drugs to address diseases with high unmet medical needs by focusing on Biology and Modality. Furthermore, we are also looking beyond our foundational Rx focus to create Rx+® healthcare solutions that combine our expertise and knowledge with cutting-edge technology in different fields of external partners. Through these efforts, Astellas stands on the forefront of healthcare change to turn innovative science into VALUE for patients. For more information, please visit our website at . Cautionary Notes In this press release, statements made with respect to current plans, estimates, strategies and beliefs and other statements that are not historical facts are forward-looking statements about the future performance of Astellas. These statements are based on management's current assumptions and beliefs in light of the information currently available to it and involve known and unknown risks and uncertainties. A number of factors could cause actual results to differ materially from those discussed in the forward-looking statements. Such factors include, but are not limited to: (i) changes in general economic conditions and in laws and regulations, relating to pharmaceutical markets, (ii) currency exchange rate fluctuations, (iii) delays in new product launches, (iv) the inability of Astellas to market existing and new products effectively, (v) the inability of Astellas to continue to effectively research and develop products accepted by customers in highly competitive markets, and (vi) infringements of Astellas' intellectual property rights by third parties. Information about pharmaceutical products (including products currently in development) which is included in this press release is not intended to constitute an advertisement or medical advice. SOURCE Astellas Pharma Inc.

Drug Approval

100 Deals associated with Praziquantel

External Link

KEGG	Wiki	ATC	Drug Bank
D00471	Praziquantel	P02BA01	DB01058

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Clonorchiasis	JP	Bayer Yakuhin Ltd.	20 Sep 1988
Paragonimiasis	JP	Bayer Yakuhin Ltd.	20 Sep 1988
Helminthiasis	CN	Hunan Er-Kang Pharmaceutical Co., Ltd.	01 Jan 1985
Trematode Infections	US	Bayer HealthCare Pharmaceuticals, Inc.	29 Dec 1982

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Schistosomiasis Haematobia	Phase 3	EG	Pharco Pharmaceuticals, Inc.	01 Dec 2011
Schistosomiasis Mansoni	Phase 3	EG	Pharco Pharmaceuticals, Inc.	01 Dec 2011

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03845140 (CTgov)	Phase 3	Schistosomiasis Mansoni	288	L-PZQ ODT 50 mg/kg (Cohort 1a: 4 to 6 Years L-PZQ ODT 50 mg/kg)	ccmzswnmws(iycyngegbh) = qdwrikdlcw grvrietvhu (bfnujvgjav, xylaxvzyra - ceapilupbx) View more	-	21 Mar 2024
				Biltricide® (Cohort 1b: 4 to 6 Years Biltricide® 40 mg/kg)	ccmzswnmws(iycyngegbh) = mvrwmhzrvz grvrietvhu (bfnujvgjav, wcifoislou - ekdanfulok) View more
NCT04635553 (Pubmed)	Not Applicable	Schistosomiasis Haematobia	777	praziquantel (Children from Mbane village)	nurkwatizj(zdfetaxuaa) = sqacelpwvj ycxsxedlgb (kaoqfwajck ) View more	-	29 Dec 2022
				praziquantel (Children from Dioundou and Khodit villages)	nurkwatizj(zdfetaxuaa) = nwulgqjrsl ycxsxedlgb (kaoqfwajck ) View more
NCT02868385 (RePST trial \| RePST, Pubmed)	Phase 3	Schistosomiasis Mansoni	167	praziquantel (Standard treatment group)	imxiaazgmg(tahuiuogkg) = tiojvhmrnl vizjcgwsvm (lyvjcwlorf, 32 - 59)	-	22 Dec 2022
				praziquantel (Intense treatment group)	imxiaazgmg(tahuiuogkg) = pzspqyzall vizjcgwsvm (lyvjcwlorf, 66 - 87)
NCT03845140 (PipelineReview) Manual	Phase 3	Schistosomiasis	-	Praziquantel	vclpzdmlrw(zzdsdglipo) = High efficacy was observed with cure rates close to or above 90% for S. mansoni (at a dose of 50 mg/kg) and S. haematobium (at a dose of 60 mg/kg). xjvwjftwar (lkqjpbbigg ) View more	Positive	16 Nov 2021
NCT04314037 (CTgov)	Phase 1	-	36	Cesol (Cesol First Administration)	wcxxtwuujz(qipknhifib) = qmlfhgjsgw kddnttoqdn (avleyztfhg, onodfawosf - ezgcpqzqms) View more	-	13 Aug 2021
				Cesol (Cesol Second Administration)	wcxxtwuujz(qipknhifib) = ndbgxodvhc kddnttoqdn (avleyztfhg, mufkodfirq - dwqcrcevap) View more
Pubmed \| Parasit Vectors	Not Applicable	Schistosomiasis Haematobia	328	Praziquantel	kcudwtjypp(trstnmztwo) = txkbfpvsnd yerehgjois (kneobkkhex ) View more	-	10 Dec 2019
NCT02806232 (CTgov)	Phase 2	Schistosomiasis Mansoni	444	Biltricide (racemate praziquantel) oral tablets (Part 1, Cohort 1: Biltricide (Racemate Praziquantel) 20 mg/kg)	secgncimth(oiupbvmtmi) = viiexnzuio liaizbnjpm (uhsthranxl, jqybpjjyyi - nsterxwgkg) View more	-	20 Nov 2019
				Biltricide (racemate praziquantel) oral tablets (Part 1, Cohort 2: Biltricide (Racemate Praziquantel) 40 mg/kg)	secgncimth(oiupbvmtmi) = zdxrywoixy liaizbnjpm (uhsthranxl, zblmymyoze - ktuxroieea) View more
NCT03133832 (Pubmed \| PLoS Negl Trop Dis)	Phase 3	Schistosomiasis Haematobia	152	Praziquantel from NPF	pjhiaauero(fclwowcaqn) = only one (a 16-years old female student), who had received the drug made in China had slight adverse reactions manifested as dizziness, headache and abdominal pain mlbqyfthpj (fsfudciyyq )	-	01 Apr 2019
				Praziquantel from Merck KGaA
ISRCTN15280205 (Pubmed \| Lancet Glob Health)	Phase 2	Schistosomiasis Mansoni	-	20 mg/kg praziquantel	iwxxtlcvbd(lrxjxibwwx) = sdfqmspwmq qinzdtfcvy (gyazrwgxzx, 44.8 - 77.5)	-	01 Jul 2017
				40 mg/kg praziquantel	iwxxtlcvbd(lrxjxibwwx) = boetuxhxpc qinzdtfcvy (gyazrwgxzx, 54.8 - 85.8)

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