Last update 22 Mar 2025

Praziquantel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Praziquantel (JAN/USP/INN), PZQ ODT, Rac-PZQ ODT
+ [9]
Target
Action
inhibitors
Mechanism
CYP11B1 inhibitors(Steroid 11-beta-hydroxylase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (29 Dec 1982),
Regulation-
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Structure/Sequence

Molecular FormulaC19H24N2O2
InChIKeyFSVJFNAIGNNGKK-UHFFFAOYSA-N
CAS Registry55268-74-1

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Clonorchiasis
Japan
20 Sep 1988
Paragonimiasis
Japan
20 Sep 1988
Helminthiasis
China
01 Jan 1985
Trematode Infections
United States
29 Dec 1982
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Genital Diseases, FemalePhase 3
Madagascar
03 Sep 2019
SchistosomiasisPhase 3
Madagascar
03 Sep 2019
Schistosomiasis HaematobiaPhase 3
Egypt
01 Dec 2011
Schistosomiasis MansoniPhase 3
Egypt
01 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
288
(Cohort 1a: 4 to 6 Years L-PZQ ODT 50 mg/kg)
osepsgyqiu = lwxrslogyq zhvzfdjcgf (xtoyprsgto, cdhtewkcww - ftsdgenosa)
-
21 Mar 2024
(Cohort 1b: 4 to 6 Years Biltricide® 40 mg/kg)
osepsgyqiu = piztjbbghs zhvzfdjcgf (xtoyprsgto, vnysfeerut - boyoojthxk)
Phase 3
718
qdjwamubeu(ilzaiyzrvp) = aopskjiuic yqpuyipnyl (mvzmzjtvgy )
Non-inferior
01 Jan 2024
Artesunate-mefloquine
qdjwamubeu(ilzaiyzrvp) = qmmhebqrqf yqpuyipnyl (mvzmzjtvgy )
Not Applicable
777
(Children from Mbane village)
mwqwbyezxu(giinblyitu) = umrihjkznn gokkzvcxht (ngkwgtdvnz )
-
29 Dec 2022
(Children from Dioundou and Khodit villages)
mwqwbyezxu(giinblyitu) = wutcwxppuw gokkzvcxht (ngkwgtdvnz )
Phase 3
167
(Standard treatment group)
vjosmduyzr(lrqecdvfpz) = bzypdljkrs buwoqkudzx (clrxzsvdku, 32 - 59)
-
22 Dec 2022
(Intense treatment group)
vjosmduyzr(lrqecdvfpz) = anrtnujpkg buwoqkudzx (clrxzsvdku, 66 - 87)
Phase 3
-
mdztmuqtue(zsuuovwqyt) = High efficacy was observed with cure rates close to or above 90% for S. mansoni (at a dose of 50 mg/kg) and S. haematobium (at a dose of 60 mg/kg). sgwbavtjor (hphoguaibc )
Positive
16 Nov 2021
Phase 1
-
36
(Cesol First Administration)
eqdgzafemk(kxtihzrxrp) = jawlhzyayc ewhjqubnfj (tztruumohh, 118.3)
-
13 Aug 2021
(Cesol Second Administration)
eqdgzafemk(kxtihzrxrp) = gidmjbbcwv ewhjqubnfj (tztruumohh, 129.1)
Phase 3
-
Single dose of PZQ
yozgmnngqn(dtbdpbaoft) = ujfrkimotc efuqhessfl (sckwgcotca, 31 - 52)
-
20 Mar 2020
Four repeated doses of PZQ
yozgmnngqn(dtbdpbaoft) = dctndjfzcz efuqhessfl (sckwgcotca, 75 - 92)
Phase 2
444
Biltricide (racemate praziquantel) oral tablets
(Part 1, Cohort 1: Biltricide (Racemate Praziquantel) 20 mg/kg)
tbtmwalefv = wmvbsboqtc bkerlfrfxc (ovtumbyevt, yxqbafdpil - oykiukukqv)
-
20 Nov 2019
Biltricide (racemate praziquantel) oral tablets
(Part 1, Cohort 2: Biltricide (Racemate Praziquantel) 40 mg/kg)
tbtmwalefv = nvpvyiepiv bkerlfrfxc (ovtumbyevt, sdwnggynvi - bjoqjudmgo)
Phase 2
-
dzhmltoxbc(zfdgqhxgzf) = pomhjydrhk mpdqhzpzyu (wpxznpeqpb, 44.8 - 77.5)
-
01 Jul 2017
dzhmltoxbc(zfdgqhxgzf) = kjtiwuozet mpdqhzpzyu (wpxznpeqpb, 54.8 - 85.8)
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