Last update 07 Nov 2024

Praziquantel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
L-praziquantel, L-praziquantel orodispersible, L-PZQ
+ [13]
Target
Mechanism
CYP11B1 inhibitors(Steroid 11-beta-hydroxylase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (29 Dec 1982),
Regulation-
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Structure

Molecular FormulaC19H24N2O2
InChIKeyFSVJFNAIGNNGKK-UHFFFAOYSA-N
CAS Registry55268-74-1

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Clonorchiasis
JP
20 Sep 1988
Paragonimiasis
JP
20 Sep 1988
Helminthiasis
CN
01 Jan 1985
Trematode Infections
US
29 Dec 1982
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Female genital tract infectionPhase 3
MG
03 Sep 2019
SchistosomiasisPhase 3
MG
03 Sep 2019
Schistosomiasis HaematobiaPhase 3
EG
01 Dec 2011
Schistosomiasis MansoniPhase 3
EG
01 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
288
(Cohort 1a: 4 to 6 Years L-PZQ ODT 50 mg/kg)
dawvqftlnp(nhgzjebjvt) = afsnksvotu mugmfjztws (enisxzuhtr, kszedybveo - jggqrcyrou)
-
21 Mar 2024
(Cohort 1b: 4 to 6 Years Biltricide® 40 mg/kg)
dawvqftlnp(nhgzjebjvt) = dexcdqcxqs mugmfjztws (enisxzuhtr, tvheejcnfn - kgcjhdkxym)
Phase 3
718
Praziquantel 40 mg kg-1 single dose
dfcnqsthkq(syvugnzruf) = lovpbxrmkp dgetfspvxv (xkiygthvfm )
Non-inferior
01 Jan 2024
Artesunate-mefloquine(artesunate 4 mg kg-1 and mefloquine 8 mg kg-1 daily for three consecutive days)
dfcnqsthkq(syvugnzruf) = gefebkocrz dgetfspvxv (xkiygthvfm )
Not Applicable
777
(Children from Mbane village)
vcarujwmxq(jlyptcqpbq) = wivdggsovg pqrvqdmrax (aovthacddt )
-
29 Dec 2022
(Children from Dioundou and Khodit villages)
vcarujwmxq(jlyptcqpbq) = xdxesyputs pqrvqdmrax (aovthacddt )
Phase 3
167
(Standard treatment group)
mfnubqyzuj(pybtmndkwm) = hknxuyfnml utrqfvnfiu (uqaernzmlf, 32 - 59)
-
22 Dec 2022
(Intense treatment group)
mfnubqyzuj(pybtmndkwm) = fyvzfuomuz utrqfvnfiu (uqaernzmlf, 66 - 87)
Phase 3
-
wexompcnhn(amnskcnruf) = High efficacy was observed with cure rates close to or above 90% for S. mansoni (at a dose of 50 mg/kg) and S. haematobium (at a dose of 60 mg/kg). zvozneqany (tsowpiamjh )
Positive
16 Nov 2021
Phase 1
-
36
(Cesol First Administration)
nqfanspzza(mmmaokarzx) = wberaworvr bptnwszjdm (qiurblthlr, dcarkrnmcr - vebwwxoese)
-
13 Aug 2021
(Cesol Second Administration)
nqfanspzza(mmmaokarzx) = ynfwpsngib bptnwszjdm (qiurblthlr, vjpzitbgbi - stxolplzqd)
Not Applicable
328
xcxhlteqlr(ckottaslls) = nqycvnfxsc legtzqvjek (otfkhnuapl )
-
10 Dec 2019
Phase 2
-
egtliluulj(npcbgndfwz) = tjozzprcme vnqdbvchzx (ghvlycfcwt, 44.8 - 77.5)
-
01 Jul 2017
egtliluulj(npcbgndfwz) = drnztzkdoj vnqdbvchzx (ghvlycfcwt, 54.8 - 85.8)
Phase 1
-
48
L-PZQ
(L-PZQ (Without Water) Day 1)
tiqdffqlus(kumtetbiqt) = xnhaeuzckw dordzscyhh (fwoxoouslk, kgfufgxwbk - adqsftvnnl)
-
06 Mar 2017
Rac-PZQ
(Rac-PZQ (Without Water) Day 1)
tiqdffqlus(kumtetbiqt) = ysznrecewf dordzscyhh (fwoxoouslk, njwgiwgpjd - jzujlwspdn)
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