Corneal Dystrophy, Epithelial Basement Membrane

Celularity will present benchtop and clinical case studies suggesting the therapeutic potential of its human placental-derived biomaterials at ICBST23, the International Conference on Biomaterials Science and Tissue EngineeringFLORHAM PARK, N.J., July 18, 2023 (GLOBE NEWSWIRE) -- Celularity Inc. (Nasdaq: CELU) (“Celularity,” “the Company”), a biotechnology company developing placental-derived allogeneic cell therapies and biomaterial products, announced today that it will present data on its proprietary extracellular matrices (ECM) at ICBST23, the International Conference on Biomaterials Science and Tissue Engineering (ICBSTE), to be held on 24-26 July in Osaka, Japan. The data will include benchtop and clinical case studies for three Celularity human placental-derived advanced biomaterial products: Biovance®, a decellularized, dehydrated human amniotic membrane (DDHAM)Biovance® 3L, a tri-layer DDHAM (DDHAM-3L)Interfyl®, a human connective tissue matrix (CTM). The data will be presented in an oral session entitled, “Therapeutic Potential of Human Placental-Derived Biomaterials,” by Anna Gosiewska, Ph.D., Vice President, Degenerative Disease Research & Development, on Wednesday, July 26 at 9:00 a.m. JST/ 8:00 p.m. EDT. Benchtop data to be presented demonstrate that: DDHAM modulates macrophage behavior, promoting polarization into M2 phenotype, and serves as a scaffold for endogenous cell attachment and proliferation in wound healing.DDHAM-3L supports human corneal epithelial cell activity and attenuates an inflammatory response over time.CTM supports tenocyte viability, proliferation, and migration, while also maintaining phenotype and attenuating the inflammatory response. CTM also serves as a scaffold for the attachment and proliferation of several cell types, including fibroblasts, monocytes, and endothelial cells, and permits monocyte differentiation into macrophages and vascular tube formation by endothelial cells. In clinical case studies, DDHAM has been used in tendon repair and wound healing, DDHAM-3L has been used in the treatment of anterior basement membrane dystrophy, and CTM has been used to treat wounds and to support the repair of soft tissues. Although these clinical case studies support the potential therapeutic opportunities for these three human placental-derived biomaterial products, additional clinical trials are needed to compare the outcomes associated with different biomaterial scaffolds in specific therapeutic applications. “Celularity’s biomaterial products are manufactured using a proprietary decellularization process that removes all residual cellular components, cells, cell debris, DNA, growth factors, and cytokines, while retaining the innate collagen framework with essential extracellular matrix (ECM) molecules in its native three-dimensional form. We believe our unique proprietary process provides superior biocompatibility, and better supports differentiated cell functions, as compared with other human placental-derived biomaterials which may contain cellular residuals,” said Robert J. Hariri, M.D., Ph.D., Celularity’s CEO, Chairman and Founder. “Our state-of-the-art GMP/GTP on-site manufacturing capability is one key aspect of Celularity’s novel business model, namely to research and develop proprietary cellular and regenerative therapeutics, including biomaterial products. We leverage a diversified portfolio of therapeutic technologies all derived from a single source material — the post-partum placenta. As the Company that pioneered the use of placental-derived stem, progenitor, and immune cells, and as an innovator in placental biomaterial product development, we continually strive to meet unmet patient needs with our novel biomaterials,” said Hariri. About Celularity Celularity Inc. (Nasdaq: CELU) headquartered in Florham Park, N.J., is a biotechnology company leading the next evolution in cellular and regenerative medicine by developing, manufacturing, and commercializing innovative biomaterial products derived from the postpartum placenta. In addition, Celularity develops allogeneic cryopreserved off-the-shelf placental-derived cell therapies, including therapeutic programs using mesenchymal-like adherent stromal cells (MLASCs), T-cells engineered with CAR (CAR-T cells), and genetically modified and unmodified natural killer (NK) cells. These therapeutic programs target indications in autoimmune, infectious and degenerative diseases, and cancer. Celularity believes that by harnessing the placenta’s unique biology and ready availability, it can develop therapeutic solutions that address significant unmet global needs for effective, accessible, and affordable therapies. To learn more, visit celularity.com Forward-Looking Statements This press release includes “forward-looking statements” within the meaning of The Private Securities Litigation Reform Act of 1995, as well as within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements other than statements of historical facts are “forward-looking statements,” including those relating to future events. In some cases, you can identify forward-looking statements by terminology such as “anticipate,” “believe,” “can,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “forecast,” “intends,” “may,” “might,” “outlook,” “plan,” “possible,” “potential,” “predict,” “project,” “seek,” “should,” “strive,” “target,” “will,” “would” and the negative of terms like these or other comparable terminology, and other words or terms of similar meaning. The forward-looking statements in this press release include express or implied statements regarding the potential application of Celularity’s advanced biomaterials, Celularity’s ability to differentiate its products from other human placental derived biomaterial products, and Celularity’s ability to advance its technology platform to develop therapeutic options for unmet patient needs, among others. Many factors could cause actual results to differ materially from those described in these forward-looking statements, including but not limited to: the inherent risks in biotechnological development, including with respect to the development of novel biomaterial products and cellular therapies, and the clinical trial and regulatory approval process; and risks associated with Celularity’s current liquidity, as well as developments relating to Celularity’s competitors and industry, along with those risk factors set forth under the caption “Risk Factors” in Celularity’s annual report on Form 10-K filed with the Securities and Exchange Commission (SEC) on March 31, 2023, and other filings with the SEC. These risks and uncertainties may be amplified by current economic situations, including inflation, supply chain issues and overall economic uncertainty. If any of these risks materialize or underlying assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. There may be additional risks that Celularity does not presently know, or that Celularity currently believes are immaterial, that could also cause actual results to differ from those contained in the forward-looking statements. In addition, these forward-looking statements reflect Celularity’s current expectations, plans, or forecasts of future events and views as of the date of this communication. Subsequent events and developments could cause assessments to change. Accordingly, forward-looking statements should not be relied upon as representing Celularity’s views as of any subsequent date, and Celularity undertakes no obligation to update forward-looking statements to reflect events or circumstances after the date hereof, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. Celularity Contact:Paul Graves, Chief Communications OfficerCelularity Inc.paul.graves@celularity.com

Celularity will present benchtop and clinical case studies suggesting the therapeutic potential of its human placental-derived biomaterials at ICBST23, the International Conference on Biomaterials Science and Tissue Engineering FLORHAM PARK, N.J., July 18, 2023 (GLOBE NEWSWIRE) -- Celularity Inc. (Nasdaq: CELU) (“Celularity,” “the Company”), a biotechnology company developing placental-derived allogeneic cell therapies and biomaterial products, announced today that it will present data on its proprietary extracellular matrices (ECM) at ICBST23, the International Conference on Biomaterials Science and Tissue Engineering (ICBSTE), to be held on 24-26 July in Osaka, Japan. The data will include benchtop and clinical case studies for three Celularity human placental-derived advanced biomaterial products: Biovance®, a decellularized, dehydrated human amniotic membrane (DDHAM) Biovance® 3L, a tri-layer DDHAM (DDHAM-3L) Interfyl®, a human connective tissue matrix (CTM). The data will be presented in an oral session entitled, “Therapeutic Potential of Human Placental-Derived Biomaterials,” by Anna Gosiewska, Ph.D., Vice President, Degenerative Disease Research & Development, on Wednesday, July 26 at 9:00 a.m. JST/ 8:00 p.m. EDT. Benchtop data to be presented demonstrate that: DDHAM modulates macrophage behavior, promoting polarization into M2 phenotype, and serves as a scaffold for endogenous cell attachment and proliferation in wound healing. DDHAM-3L supports human corneal epithelial cell activity and attenuates an inflammatory response over time. CTM supports tenocyte viability, proliferation, and migration, while also maintaining phenotype and attenuating the inflammatory response. CTM also serves as a scaffold for the attachment and proliferation of several cell types, including fibroblasts, monocytes, and endothelial cells, and permits monocyte differentiation into macrophages and vascular tube formation by endothelial cells. In clinical case studies, DDHAM has been used in tendon repair and wound healing, DDHAM-3L has been used in the treatment of anterior basement membrane dystrophy, and CTM has been used to treat wounds and to support the repair of soft tissues. Although these clinical case studies support the potential therapeutic opportunities for these three human placental-derived biomaterial products, additional clinical trials are needed to compare the outcomes associated with different biomaterial scaffolds in specific therapeutic applications. “Celularity’s biomaterial products are manufactured using a proprietary decellularization process that removes all residual cellular components, cells, cell debris, DNA, growth factors, and cytokines, while retaining the innate collagen framework with essential extracellular matrix (ECM) molecules in its native three-dimensional form. We believe our unique proprietary process provides superior biocompatibility, and better supports differentiated cell functions, as compared with other human placental-derived biomaterials which may contain cellular residuals,” said Robert J. Hariri, M.D., Ph.D., Celularity’s CEO, Chairman and Founder. “Our state-of-the-art GMP/GTP on-site manufacturing capability is one key aspect of Celularity’s novel business model, namely to research and develop proprietary cellular and regenerative therapeutics, including biomaterial products. We leverage a diversified portfolio of therapeutic technologies all derived from a single source material — the post-partum placenta. As the Company that pioneered the use of placental-derived stem, progenitor, and immune cells, and as an innovator in placental biomaterial product development, we continually strive to meet unmet patient needs with our novel biomaterials,” said Hariri. About Celularity Celularity Inc. (Nasdaq: CELU) headquartered in Florham Park, N.J., is a biotechnology company leading the next evolution in cellular and regenerative medicine by developing, manufacturing, and commercializing innovative biomaterial products derived from the postpartum placenta. In addition, Celularity develops allogeneic cryopreserved off-the-shelf placental-derived cell therapies, including therapeutic programs using mesenchymal-like adherent stromal cells (MLASCs), T-cells engineered with CAR (CAR-T cells), and genetically modified and unmodified natural killer (NK) cells. These therapeutic programs target indications in autoimmune, infectious and degenerative diseases, and cancer. Celularity believes that by harnessing the placenta’s unique biology and ready availability, it can develop therapeutic solutions that address significant unmet global needs for effective, accessible, and affordable therapies. To learn more, visit celularity.com Forward-Looking Statements This press release includes “forward-looking statements” within the meaning of The Private Securities Litigation Reform Act of 1995, as well as within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements other than statements of historical facts are “forward-looking statements,” including those relating to future events. In some cases, you can identify forward-looking statements by terminology such as “anticipate,” “believe,” “can,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “forecast,” “intends,” “may,” “might,” “outlook,” “plan,” “possible,” “potential,” “predict,” “project,” “seek,” “should,” “strive,” “target,” “will,” “would” and the negative of terms like these or other comparable terminology, and other words or terms of similar meaning. The forward-looking statements in this press release include express or implied statements regarding the potential application of Celularity’s advanced biomaterials, Celularity’s ability to differentiate its products from other human placental derived biomaterial products, and Celularity’s ability to advance its technology platform to develop therapeutic options for unmet patient needs, among others. Many factors could cause actual results to differ materially from those described in these forward-looking statements, including but not limited to: the inherent risks in biotechnological development, including with respect to the development of novel biomaterial products and cellular therapies, and the clinical trial and regulatory approval process; and risks associated with Celularity’s current liquidity, as well as developments relating to Celularity’s competitors and industry, along with those risk factors set forth under the caption “Risk Factors” in Celularity’s annual report on Form 10-K filed with the Securities and Exchange Commission (SEC) on March 31, 2023, and other filings with the SEC. These risks and uncertainties may be amplified by current economic situations, including inflation, supply chain issues and overall economic uncertainty. If any of these risks materialize or underlying assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. There may be additional risks that Celularity does not presently know, or that Celularity currently believes are immaterial, that could also cause actual results to differ from those contained in the forward-looking statements. In addition, these forward-looking statements reflect Celularity’s current expectations, plans, or forecasts of future events and views as of the date of this communication. Subsequent events and developments could cause assessments to change. Accordingly, forward-looking statements should not be relied upon as representing Celularity’s views as of any subsequent date, and Celularity undertakes no obligation to update forward-looking statements to reflect events or circumstances after the date hereof, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. Celularity Contact: Paul Graves, Chief Communications Officer Celularity Inc. paul.graves@celularity.com

Salt Lake City, Utah--(News - July 5, 2022) - Kiora Pharmaceuticals, Inc. (NASDAQ: KPRX), ("Kiora" or the "Company") today announced enrolling the first patient as a part of a Phase 2 study evaluating KIO-201 topical eye drops in patients with Persistent Corneal Epithelial Defect (PCED), a rare ocular surface condition characterized by non-healing wounds on the eye surface. "We believe KIO-201 has the potential to address a rare ophthalmic condition in patients who have limited effective treatment options," said Brian M. Strem, Ph.D., President and Chief Executive Officer of Kiora. "Our KIO-201 asset has an extensive portfolio of clinical data demonstrating its ability to improve healing in difficult-to-treat corneal wounds. Promising results from this study will support our efforts to advance KIO-201 to a potential registration study." The trial is designed as a single-arm, open label ten patient (up to 20 eyes) study. Patients will be evaluated at 28 days after receiving KIO-201 six times daily. The endpoints include safety and tolerability︎, as well as the percentage of patients with corneal healing and the associated time to healing. KIO-201 is a chemically modified form of the natural polymer hyaluronic acid, designed to accelerate natural corneal wound healing. It is formulated as a convenient eye drop and provides a thin coating to the surface of the eye, serving as a protectant to facilitate and accelerate corneal re-epithelization. The chemical modifications enable enhanced viscoelastic properties and a longer ocular surface resonance time compared to standard hyaluronic acid. Kiora is exploring KIO-201 as a treatment for PCED, a condition characterized by an inability of the cornea to properly repair the protective epithelial surface of the eye. This can be due to a variety of factors including physical trauma, surgical injury, infections or inflammatory ocular diseases. It is estimated that there are fewer than 200,000 patients diagnosed annually in the United States with PCED[1]. About Kiora Pharmaceuticals Kiora Pharmaceuticals is a clinical-stage biotechnology company developing and commercializing products for the treatment of ophthalmic diseases. KIO-301 is being developed for the treatment of retinitis pigmentosa. It is a molecular photoswitch that has the potential to restore vision in patients with inherited and/or age-related retinal degeneration. KIO-101 is being developed for the treatment of the Ocular Presentation of Rheumatoid Arthritis ("OPRA"). It is a next-generation, non-steroidal, immuno-modulatory and small molecule inhibitor of Dihydroorotate Dehydrogenase ("DHODH") with what Kiora believes is best-in-class picomolar potency and a validated immune modulating mechanism (blocks T cell proliferation and proinflammatory cytokine release) designed to overcome the off-target side effects and safety issues associated with commercially available DHODH inhibitors. In addition, Kiora is developing KIO-201, a modified form of the natural polymer hyaluronic acid, designed to accelerate corneal wound healing. In addition to news releases and SEC filings, we expect to post information on our website, , and social media accounts that could be relevant to investors. We encourage investors to follow us on Twitter and LinkedIn as well as to visit our website and/or subscribe to email alerts. Forward-Looking Statements Some of the statements in this press release are "forward-looking" and are made pursuant to the safe harbor provision of the Private Securities Litigation Reform Act of 1995. These "forward-looking" statements include statements relating to, among other things, results from this study that could support Kiora's efforts to advance KIO-201 to more advanced stages of clinical development, the development and commercialization efforts and other regulatory or marketing approval efforts pertaining to Kiora's development-stage products, including KIO-101, KIO-201 and KIO-301, as well as the success thereof, with such approvals or success may not be obtained or achieved on a timely basis or at all. These statements involve risks and uncertainties that may cause results to differ materially from the statements set forth in this press release, including, among other things, the ability to conduct clinical trials on a timely basis, market and other conditions and certain risk factors described under the heading "Risk Factors" contained in Kiora's Annual Report on Form 10-K filed with the SEC on April 15, 2022 or described in Kiora's other public filings. Kiora's results may also be affected by factors of which Kiora is not currently aware. The forward-looking statements in this press release speak only as of the date of this press release. Kiora expressly disclaims any obligation or undertaking to release publicly any updates or revisions to such statements to reflect any change in its expectations with regard thereto or any changes in the events, conditions, or circumstances on which any such statement is based, except as required by law. Investor Contact Francina Agosti, PhD (617) 546-0742 fagosti@reportablenews.com [1] Vaidyanathan U, Hopping GC, Liu HY, et al. Persistent Corneal Epithelial Defects: A Review Article. Med Hypothesis Discov Innov Ophthalmol. 2019;8(3):163-176. To view the source version of this press release, please visit