Last update 01 Nov 2024

Severe acne

Last update 01 Nov 2024

Basic Info

Synonyms

Severe acne

Introduction-

Drugs associated with Severe acne

Adapalene/Benzoyl Peroxide

Target

RARs

Mechanism

RARs agonists

Active Org.

Maruho Co., Ltd. [+2]

Originator Org.

Galderma Holding SA

Active Indication

Acne Vulgaris

Inactive Indication

Severe acne

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date08 Dec 2008

Viaminati

Target

RARs

Mechanism

RARs agonists

Active Org.

Jinzhou Jiutai Pharmaceutical Co. Ltd.

Originator Org.

Jinzhou Jiutai Pharmaceutical Co. Ltd.

Active Indication

Severe acne

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date01 Jan 1996

Doxycycline Hyclate

Target

30S subunit

Mechanism

30S subunit inhibitors

Active Org.

CHARTWELL RX SCIENCES LLC [+4]

Originator Org.

Pfizer Inc.

Active Indication

Anthrax [+22]

Inactive Indication

Lyme Disease [+2]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date05 Dec 1967

Clinical Trials associated with Severe acne

JPRN-jRCT2071220075 / CompletedPhase 1IIT

A Phase I Study of Isotretinoin Capsules in Japanese Healthy Adult Male Subjects.(Dose Escalation and Food Effect Studies)

Start Date28 Nov 2022

Sponsor / Collaborator-

TCTR20220420002 / Not yet recruitingPhase 1IIT

Whey Protein and Severity of Male Acne: a double-blinded, randomized controlled trial

Start Date01 May 2022

Sponsor / Collaborator-

ChiCTR2100042950 / RecruitingPhase 4IIT

Efficacy and safety of Broda 30% supramolecular salicylic acid in the treatment of severe acne

Start Date01 Feb 2021

Sponsor / Collaborator

The First Hospital Of China Medical University

100 Clinical Results associated with Severe acne

100 Translational Medicine associated with Severe acne

0 Patents (Medical) associated with Severe acne

Literatures (Medical) associated with Severe acne

11 Mar 2024·Cureus

Side Effects of Treating Acne Vulgaris With Isotretinoin: A Systematic Review

Review

Author: Anjankar, Vaibhav P ; Rajput, Ishika

The treatment of acne vulgaris poses a significant challenge due to its chronic nature and potential influence on patients' quality of life. Isotretinoin, a systemic retinoid, has emerged as one of the most efficient treatment options for chronic, severe acne. However, the use of isotretinoin is associated with a range of side effects that require careful consideration. This review article provides a comprehensive overview of the side effects linked to isotretinoin treatment for acne vulgaris. Through an analysis of existing literature and clinical studies, we discuss the various adverse reactions, their incidence, management strategies, and the influence of these side effects on patients' quality of life.

01 Jun 2020·Clinical RheumatologyQ3 · MEDICINE

Demographic, clinical, and scintigraphic comparison of patients affected by palmoplantar pustulosis and severe acne: a retrospective study

Q3 · MEDICINE

Article

Author: Li, Chen ; Li, Qiyi ; Li, Feng ; Sun, Xiaochuan ; Wu, Nan ; Li, Li ; Wu, Zhihong ; Li, Yueting

OBJECTIVESynovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome encompasses heterogeneous dermatological manifestations, mainly palmoplantar pustulosis (PPP) and severe acne (SA). This study aims to explore the necessity of stratified management according to skin lesions.METHODSIn a cohort of SAPHO patients, we compared the demographic, clinical, and scintigraphic characteristics of the SAPHO patients whose skin lesion was PPP or SA.RESULTSA total of 249 patients were included (227 affected by PPP and 22 affected by SA). Patients with SA were younger at onset (20, interquartile ranges (IQR) 15-30 vs. 37, IQR 30-46 years old; p < 0.001) and enrollment (35, IQR 25-38 vs. 41, IQR 33-50 years old; p = 0.001), and they had a prolonged disease duration (88.5 months, IQR 18.7-216.0 vs. 16.0, IQR 7.0-48.0 months; p < 0.001) and time needed for diagnosis (7.5, IQR 2.0-19.0 vs. 1.0, IQR 1.0-4.0 years; p < 0.001). Adjusted by age, sex, and disease duration, SA was significantly associated with more disease-modifying anti-rheumatic drug (DMARD) use (adjusted odds ratio (OR) 3.72; 95% confidence interval (CI) 1.23, 12.62; p = 0.019) and more sternoclavicular joint involvement (adjusted OR 5.91; 95% CI 1.17, 61.3; p = 0.030) in two separate Firth's logistic regression models.CONCLUSIONSAPHO patients affected by PPP or SA as the only skin lesion may have different epidemiologic features, osteoarticular manifestations, and treatment history.Key Points• SAPHO patients with PPP or SA were heterogenous in both demographic, clinical, and imaging features.• SAPHO patients with SA were mainly male and had a significantly younger age and longer duration of symptoms before diagnosis.• SA in SAPHO patients was significantly associated with more sternoclavicular involvement and more DMARD use history.

01 May 2015·Journal of the European Academy of Dermatology and VenereologyQ2 · MEDICINE

Comparison of adrenocortical steroidogenesis in women with post‐adolescent severe acne and polycystic ovary syndrome

Q2 · MEDICINE

Article

Author: Elcin, G. ; Cinar, N. ; Cetinozman, F. ; Aksoy, D.Y. ; Yildiz, B.O.

AbstractBackgroundIncreased adrenocortical production appears to be associated with acne and hirsutism in acne and polycystic ovary syndrome (PCOS). However, the aetiological role of androgens in the pathogenesis of acne per se is far from being clear.ObjectiveWe aimed to evaluate adrenocortical function in women with post‐adolescent severe acne in comparison with patients with PCOS and healthy women.MethodsThe study included 32 women with post‐adolescent severe acne, 32 women with PCOS and 32 age and body mass index (BMI)‐matched healthy controls (age 17–34 years, BMI: 20.8 ± 1.9 kg/m²). Women with acne did not have hirsutism or ovulatory dysfunction whereas all PCOS patients had androgen excess and ovulatory dysfunction. Measurements included basal testosterone (T), sex hormone‐binding globulin (SHBG) and dehydroepiandrosterone sulphate (DHEAS) levels and serum 17‐hydroxyprogesterone (17‐OHP), androstenedione (A4), DHEA and cortisol levels in response to corticotropin (ACTH) stimulation.ResultsT, free androgen index, DHEAS levels, basal and AUC (area under the curve) values for A4 were significantly higher in PCOS than women with acne and controls (P < 0.05 for all), whereas three groups did not differ for basal or AUC values of DHEA and cortisol. Women with PCOS and those with severe acne had significantly and similarly higher AUC values of 17‐OHP compared to controls (P < 0.05).ConclusionWomen with isolated post‐adolescent severe acne do not have increased levels of adrenal androgens basally or in response to ACTH. However, these women have similar secretion pattern of 17‐OHP with PCOS patients suggesting increased enzymatic activity in this pathway.

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Severe acne

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