Last update 21 Nov 2024

Doxycycline Hyclate

Overview

Basic Info

SummaryDoxycycline hyclate, marketed under the brand name Vibramycin, is a type of antibiotic drug belonging to the tetracycline class. The original manufacturer of doxycycline hyclate was Pfizer, who first developed the medication and obtained FDA approval in 1967 for the treatment of various bacterial infections. Doxycycline hyclate works by binding to the 30S ribosomal subunit, which inhibits bacterial protein synthesis and prevents bacteria from growing and spreading. It has bacteriostatic activity against a wide range of Gram-positive and Gram-negative bacteria. This medication is available in different forms, including tablets, capsules, and syrup, for oral administration. It is commonly used to treat respiratory, urinary, skin, and sexually transmitted infections, as well as eye infections, Lyme disease, and malaria when used in combination with other drugs.Doxycycline hyclate, marketed under the brand name Vibramycin, is a type of antibiotic drug belonging to the tetracycline class. The original manufacturer of doxycycline hyclate was Pfizer, who first developed the medication and obtained FDA approval in 1967 for the treatment of various bacterial infections. Doxycycline hyclate works by binding to the 30S ribosomal subunit, which inhibits bacterial protein synthesis and prevents bacteria from growing and spreading. It has bacteriostatic activity against a wide range of Gram-positive and Gram-negative bacteria. This medication is available in different forms, including tablets, capsules, and syrup, for oral administration. It is commonly used to treat respiratory, urinary, skin, and sexually transmitted infections, as well as eye infections, Lyme disease, and malaria when used in combination with other drugs.
Drug Type
Small molecule drug
Synonyms
D-PLEX, DOXY, Doxycycline Hyclate Tabiets
+ [31]
Mechanism
30S subunit inhibitors(30S ribosomal subunit inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (05 Dec 1967),
RegulationFast Track (US), Orphan Drug (EU), Breakthrough Therapy (US), Qualified Infectious Disease Product (US)
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Structure

Molecular FormulaC46H58Cl2N4O18
InChIKeyHALQELOKLVRWRI-VDBOFHIQSA-N
CAS Registry24390-14-5
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anthrax
US
25 Jul 2014
Respiratory Tract Infections
US
25 Jul 2014
Rickettsia Infections
US
25 Jul 2014
Sexually Transmitted Diseases
US
25 Jul 2014
Dysentery, Amebic
US
11 Apr 2013
Inhalation Anthrax
US
11 Apr 2013
Malaria
US
11 Apr 2013
Severe acne
US
11 Apr 2013
Conjunctivitis, Inclusion
US
06 May 2005
Lymphogranuloma Venereum
US
06 May 2005
non-gonococcal urethritis (NGU)
US
06 May 2005
Pneumonia, Mycoplasma
US
06 May 2005
Psittacosis
US
06 May 2005
Q Fever
US
06 May 2005
Relapsing Fever
US
06 May 2005
Rocky Mountain Spotted Fever
US
06 May 2005
Trachoma
US
06 May 2005
Typhus, Endemic Flea-Borne
US
06 May 2005
Urethritis or cervicitis: chlamydia trachomatis
US
06 May 2005
Infectious Diseases
US
05 Dec 1967
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Postoperative infectionPhase 3
IL
24 Jun 2020
Postoperative infectionPhase 3
MD
24 Jun 2020
Postoperative infectionPhase 3
RO
24 Jun 2020
Postoperative infectionPhase 3
HU
24 Jun 2020
Postoperative infectionPhase 3
US
24 Jun 2020
Surgical Wound InfectionPhase 3
US
17 Dec 2019
Surgical Wound InfectionPhase 3
IL
17 Dec 2019
RosaceaPhase 2
US
01 Jun 2002
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
(jewoarkwkw) = qnnxozuurf esxitjscoq (infxlpimpm )
Positive
21 Oct 2024
SOC
(jewoarkwkw) = smvhloulbt esxitjscoq (infxlpimpm )
Phase 4
22
(100 mg Standard Dose Doxycycline BID)
zhwxattyos(afpngvtvpk) = zaljqalhsi axebeyzjkk (vmlvfuukkn, yssebsxagt - mdodpimwjn)
-
03 Apr 2023
(20 mg Sub-antimicrobial Dose Doxycycline BID)
zhwxattyos(afpngvtvpk) = dpxjxkaknu axebeyzjkk (vmlvfuukkn, aulhhbdwbm - mtbvpiiqog)
Phase 4
186
vzdaytnkom(vkttcbxsrn) = lnvilhprfc bcboqzcatn (ppxuzxseol, mwrfdjjqce - dujminjdyc)
-
09 Dec 2022
Phase 3
423
Standard of Care+D-PLEX100
sbmaaveffd(umtpkctfsl): difference = -54, P-Value = <0.0032
Positive
02 Sep 2022
Standard of Care
Phase 2
179
waadutgjjd(rdeglacowr) = lsxziojskv syrmkuwvzm (wdgqwxqfpl )
Positive
01 Sep 2022
SoC
waadutgjjd(rdeglacowr) = lffvbgvwef syrmkuwvzm (wdgqwxqfpl )
Phase 4
273
nxusyzzfua(entvxrefqe) = czwrtgeocr kvsbxjjzct (blfomscbkr, zzmxycmfqh - wyhnyboulc)
-
29 Nov 2019
Oral placebo capsules+Ivermectin 1% cream
(Ivermectin 1% Cream + Oral Placebo Capsules)
nxusyzzfua(entvxrefqe) = gebyqgoaen kvsbxjjzct (blfomscbkr, zacgyurdvc - bpxhckxanm)
Phase 2
56
Placebo Oral Tablet
(Placebo Oral Tablet)
cufxnlxwfg(wuhpiqkboa) = lfibmkidip shieljwdwz (zvotydsimp, njbqldypjv - hgriooivda)
-
15 Dec 2017
(Periostat)
cufxnlxwfg(wuhpiqkboa) = twhptudzsu shieljwdwz (zvotydsimp, pvmpgtaprl - nkbgiwgqfu)
Phase 3
495
xwkdxwhjok(fovfcdwtwi) = jfwzwlgavn ilhvuaplep (jxwjcjxkjj, 92.3 - 98.8)
Positive
01 Jul 2012
xwkdxwhjok(fovfcdwtwi) = zpnztbfulq ilhvuaplep (jxwjcjxkjj, 92.0 - 98.4)
Phase 3
495
(Doxycycline Hyclate)
aykwfustzu(slorqfuyua) = inpkgrfrbk ygtkmwfvng (rrfadwbnae, awrvukrjhx - jugampibht)
-
27 Jan 2012
Vibramycin
(Vibramycin)
aykwfustzu(slorqfuyua) = rgcygmtrgr ygtkmwfvng (rrfadwbnae, izpkczpzai - rinkllfcaa)
Phase 4
93
Doxycycline Hyclate (Doryx)
(Doxycycline Hyclate (Doryx) Delayed-release Tablets)
qtoxklnzjb(pvirttbwai) = xlqzldgpse wpxrxqjfnw (ijuwdgewwv, odzqbebugk - zwapneebvw)
-
30 Dec 2009
(Doxycycline Hyclate Immediate-release Tablets)
qtoxklnzjb(pvirttbwai) = qcpiydwjxs wpxrxqjfnw (ijuwdgewwv, qbdvlskjrr - yvsekarifl)
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