Synonyms Arterioscleroses, Intracranial, Arteriosclerosis, Intracranial, Intracranial Arterioscleroses + [15] |
Introduction Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS. |
Target |
Mechanism PDE5A inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. KR |
First Approval Date29 Nov 2005 |
Target- |
Mechanism- |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. CN |
First Approval Date30 Nov 2002 |
Target |
Mechanism KCNK inhibitors [+1] |
Active Org. |
Originator Org. |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. CN |
First Approval Date30 Sep 2002 |
Start Date15 Feb 2025 |
Sponsor / Collaborator- |
Start Date01 Dec 2024 |
Sponsor / Collaborator |
Start Date01 Dec 2024 |
Sponsor / Collaborator |