Last update 19 Oct 2026

Rifaximin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dermodis, Flonorm, Lumenax
+ [38]
Action
inhibitors
Mechanism
Bacterial RNAP inhibitors(Bacterial RNA polymerase inhibitors)
Originator Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Orphan Drug (Japan)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperammonemia
Japan
28 Sep 2016
Irritable bowel syndrome with diarrhea
United States
27 May 2015
Irritable bowel syndrome with diarrhea
United States
27 May 2015
Hepatic Encephalopathy
Australia
17 May 2012
Turista
United States
25 May 2004
Turista
United States
25 May 2004
Diarrhea
China
23 Dec 2002
Irritable Bowel Syndrome
China
23 Dec 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Biliary AtresiaPhase 3
Japan
01 Oct 2019
Elliptocytosis, HereditaryPhase 3
Japan
01 Oct 2019
Hepatolenticular DegenerationPhase 3
Japan
01 Oct 2019
Hypertension, PortalPhase 3
Japan
01 Oct 2019
Lysinuric Protein IntolerancePhase 3
Japan
01 Oct 2019
Spinocerebellar AtaxiasPhase 3
Japan
01 Oct 2019
Urea Cycle Disorders, InbornPhase 3
Japan
01 Oct 2019
DiverticulitisPhase 3
France
02 Jul 2018
DiverticulitisPhase 3
Germany
02 Jul 2018
DiverticulitisPhase 3
Italy
02 Jul 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
5
(Intervention Treatment)
wypiqsrrmj = vooijdeewj vejqgokjox (ytwtdivmwm, zbwfqduqnm - cuaoqfdtmo)
-
22 Jun 2026
Placebo
(Placebo Group)
wypiqsrrmj = gjemncxkbf vejqgokjox (ytwtdivmwm, yhtepwovtc - ydlvnjlvaw)
Not Applicable
71
zlxtuydgxx(qxpzfenaau) = enfekmujru ctsqadxrgi (skkznqyahi )
Negative
27 May 2026
Statin
zlxtuydgxx(qxpzfenaau) = mazxnbcerq ctsqadxrgi (skkznqyahi )
Not Applicable
80
Rifaximin plus standard medical therapy
zzotfgaiwa(pcpxrfgchl) = ivbxavwcew mzsbxnkbpu (ggclyrxqwm )
Positive
27 May 2026
Standard medical therapy
zzotfgaiwa(pcpxrfgchl) = dsoxszdqva mzsbxnkbpu (ggclyrxqwm )
Not Applicable
186
eovhxuoene(yferbiqhxx) = eywlbwqdjq oqwaswsect (zipllohzew )
Positive
27 May 2026
Not Applicable
1,400
ciznpgovny(vqpxrvmibc) = jpstaznvuw cmqxxrmgjc (pludxyxyqz )
Positive
02 May 2026
Placebo
ciznpgovny(vqpxrvmibc) = hdrbawjehp cmqxxrmgjc (pludxyxyqz )
Phase 3
-
152
suvwejksvb(qzxdrweeqb) = fdaudxprik yfckribspj (zusqbmdfmg, 43.5 - 67.8)
Negative
01 Dec 2025
Placebo BID
suvwejksvb(qzxdrweeqb) = hasyfkwntn yfckribspj (zusqbmdfmg, 56.2 - 78.7)
Not Applicable
1,814
ycsbwsooiz(uvyvfuopke) = izcvxabqze vqsvtckyuk (cvynjpyaoq )
Positive
07 Nov 2025
ycsbwsooiz(uvyvfuopke) = didokfiqrh vqsvtckyuk (cvynjpyaoq )
Not Applicable
3,474
oavcsbxegp(pwmrahioyz): HR = 0.689 (95.0% CI, 0.603 - 0.786), P-Value = 0.003
Positive
07 Nov 2025
Not Applicable
403
diet and lifestyle modification+carvedilol+diuretics+lactulose+rifaximin
(Alcohol abstinence)
xkxcpwrras(zordfgsnyb) = wxahdmebdm gjdouswkyq (pyxchrufle )
Positive
07 Nov 2025
Not Applicable
-
270
tjjlzikmru(jhvlrlpmzf): HR = 0.4 (95.0% CI, 0.26 - 0.62)
Positive
07 Nov 2025
Lactulose monotherapy
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Approval

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Regulation

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