Efficacite et Innocuite du Tannate de Gelatine Dans le Traitement de la Diarrhee aiguë de l'Enfant. Une Etude Randomisee, Controlee, en Double Aveugle (INDIGO)

To evaluate the safety, global efficacy and rapidity of action of GT in children with acute gastroenteritis taking ORS solution.

Start Date11 Sep 2019

Sponsor / Collaborator

Ferrer Internacional SA

[+1]

100 Clinical Results associated with Tannic Acid

100 Translational Medicine associated with Tannic Acid

100 Patents (Medical) associated with Tannic Acid

7,269

Literatures (Medical) associated with Tannic Acid

01 Feb 2025·Food Chemistry

Highly cost-effective wheat starch-stearic acid complexes enabled by microwave processing: Structural properties, anti-digestion, and molecular dynamics simulation

Article

Author: Ma, Ji ; Gao, Tingting ; Pan, Fei ; Tian, You ; Sun, Da-Wen

Microwave (MW) heating shows higher efficiency in preparing wheat starch-stearic acid (WS-SA) complexes than the traditional water bath (WB) heating method, while the detailed "time-energy-quality" evaluations and the potential anti-digestion mechanism of the MW-processed WS-SA remain further exploration. In this study, 95 % time cost and 73 % energy consumption were saved when using MW processing WS-SA, and the MW-processed complexes were verified to show significantly higher relative crystallinity, short-range ordered structure degree, thermal stability, complex index, and resistant starch content. Molecular dynamics (MD) simulation demonstrated that MW treatment notably facilitated the binding rate of amylose and SA molecules, generating a tight and stable helical structure through hydrogen bonds and van der Waals forces. Analyses of solvent-accessible surface area and water status cross-verified that the denser structure could endow the MW-processed complexes with higher resistance to water solvation effects and correspondingly reduce the water mobility for enzymatic hydrolysis reactions, ultimately making the MW-processed complexes more undigestible. This study provides a further understanding of the anti-digestion mechanisms of the MW-processed WS-SA from the molecular level, and it is expected that the current work could attract more concerns to the highly cost-effective MW heating method for processing starchy food.

01 Jan 2025·Food Chemistry

Study on the mechanism of polyphenols regulating the stability of pea isolate protein formed Pickering emulsion based on interfacial effects

Article

Author: Ma, Lulu ; Huo, Jiaying ; Li, Shugang ; Yang, Xiaofan ; Jiaying, Huo

To improve the stability of pea isolate protein (PPI) Pickering emulsions, this study compared the stability effects of tannic acid (TA), epigallocatechin gallate, and gallic acid on PPI, and found PPI-TA the strongest binding and the best stability. When TA concentration increased from 0 to 0.5 mmol/L, the average particle size, zeta potential, and surface hydrophobicity of PPI-TA particles decreased by 23.1 %, 17.1 %, and 63.3 % respectively. The highest viscosity and elastic storage modulus G' which was also higher than and parallel to the loss modulus G", and the lowest Turbiscan stability index were observed in the emulsion with 0.5 mmol/L TA, indicating an elastic-based gel-like texture. The concentrations of conjugated diene and thiobarbituric acid reactive substances (TBARS) were also reduced by more than 58 %, showing improved oxidative stability. The study provides new insights into the interfacial behavior of PPI-polyphenols and technical support for their applications in food industry.

01 Jan 2025·Brain Research

Quinic acid contributes to neurogenesis: Targeting Notch pathway a key player in hippocampus

Article

Author: Shahid, Maha ; Iftikhar, Kanwal ; Niaz, Maryam ; Faizi, Shaheen ; Usman Simjee, Shabana

Coordinated proliferation and differentiation of neural stem cells (NSCs) results in continuous neurogenesis. The present study provides novel insights into the Notch intracellular signaling in neuronal cell proliferation, maintenance, migration, and differentiation regulated by naturally based Quinic acid (QA) in primary hippocampal cell culture. Further, this study might help in the discovery and development of lead molecules that can overcome the challenges in the treatment of neurodegenerative diseases. The growth supporting effect of QA was studied using Alamar Blue assay. The migratory potential of QA was evaluated using scratch assay. The in vitro H₂O₂-induced oxidative stress model was used to upregulate neuronal survival after QA treatment. The RT-qPCR and immunocytochemical analysis were performed for selected markers of Notch signaling to determine the proliferation, differentiation, and maintenance of NSCs at gene and molecular levels. The Mash1 and Ngn2 are the upstream proneural genes of the Notch pathway which were included to evaluate the differentiation of NSCs into mature neurons after treatment with QA. Furthermore, regarding the role of QA in maintaining the pool of NPCs, we used Notch1 and Hes1 markers for proliferation analysis. Also, secondary neuronal markers i.e. Pax6, PCNA, and Mcm2 were included in this study and their gene expression analysis was analyzed following treatment with QA. Based on the study's results, we suggest that naturally based QA can promote the growth and differentiation of neonatal NSCs residing in hippocampal regions into neuronal lineage. Therefore, we propose that the neurogenic potential of QA can be employed to prevent and treat neurodegenerative diseases.

News (Medical) associated with Tannic Acid

13 Feb 2024

·www.sciencedaily.com

Personalized adhesives for inner healing -- now tailored just for you

Scientists develop novel underwater bio-adhesive patches with mussel adhesive protein. The field of adhesives is diverse, catering to a wide range of applications from everyday uses like paper and fabric to specialized ones like woodwork. In the medical area, adhesives play a crucial role, from suturing internal wounds to attaching sensors and implanting medical devices. A recent breakthrough in this field has generated considerable excitement: the development of medical adhesives that are not only safe for human use but also customizable for different organs. Professor Hyung Joon Cha from the Department of Chemical Engineering and the School of Convergence Science and Technology at Pohang University of Science and Technology (POSTECH), along with PhD candidate Jang Woo Yang (Department of Chemical Engineering, POSTECH), senior researcher Hwa Hui Shin from the Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub), and Professor Kang-Il Song from the Division of Smart Healthcare at Pukyong National University (PKNU), have garnered attention by using mussel-derived adhesive proteins to develop customized underwater bio-adhesive patches (CUBAP). This research will be featured as a frontispiece in the upcoming issue of Advanced Materials and has secured both domestic and international patents. These patches are crucial in effectively sealing internal wounds, leaks, and perforations in the body's organs, aiding in healing and tissue regeneration. As research in internal transplant devices expands, there is a growing need for adhesives that can securely hold these devices in place. The biomedical adhesives used in such applications need to maintain strong adhesion underwater while minimizing side effects. The ability to customize features like biodegradation time is also essential, considering the unique biological environments of different organs. Professor Hyung Joon Cha's research team members, pioneers in applying mussel adhesive proteins for medical adhesives, have taken a step further with the development of CUBAP. This adhesive is not only excellent in underwater adhesion but is also made from natural materials, ensuring safety and biocompatibility within the human body. The team has produced customized patches (CUBAP) by combining mussel adhesive protein with polyacrylic acid and polymethacrylic acid, and these are currently undergoing clinical evaluation for minimizing scarring in skin closures. In its dry state, the patch is non-adhesive, but in the human body or other humid environments, it exhibits strong adhesive properties. Furthermore, researchers can control the degradation time and mechanical hardness by adjusting the polyacrylic acid and polymethacrylic acid ratios. This enables a customized adhesive system, considering the diverse structural and biological needs of different organs. The research team created three types of customized adhesive patches and applied them in animal treatments and implants. These patches maintained high adhesion even in highly mobile organs such as the heart and bladder. They also conducted successful experiments in adjusting biodegradation times and flexibility during the transplantation of muscle regeneration electronic devices. Professor Cha, the lead researcher, emphasized, "This research paves the way for personalized medical applications. We plan to enhance and refine the process through subsequent studies, with the goal of effective applications in diverse biomedical fields." Senior Researcher Hwa Hui Shin from K-MEDI Hub shared, "Our study has confirmed the effectiveness and versatility of the developed bio-adhesive patches. We look forward to their evolving into commercial products, meeting the demands of the healthcare sector." This research was supported by the Mid-Career Research Program, the Young Research Program, and the Nano Material Technology Development Program through the National Research Foundation of Korea.

21 Jun 2023

·www.sciencedaily.com

Plant extracts used by indigenous people hold promise in treatment of ataxia

Researchers have discovered that extracts from plants used by the Kwakwaka'wakw First Nations peoples in their traditional botanical medicine practices are able to rescue the function of ion channel proteins carrying mutations that cause human Episodic Ataxia. A University of California, Irvine-led team of researchers have discovered that extracts from plants used by the Kwakwaka'wakw First Nations peoples in their traditional botanical medicine practices are able to rescue the function of ion channel proteins carrying mutations that cause human Episodic Ataxia. The study, "Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain" was published in June in Nature Communications. "Episodic Ataxia 1 (EA1) is a movement disorder caused by inherited mutations in the human KCNA1 gene, which encodes Kv1.1, a voltage-gated potassium channel essential for normal function of the human nervous system," said Geoffrey W. Abbott, PhD, vice dean of basic science research and professor in the Department of Physiology & Biophysics at the UCI School of Medicine. "We found that extracts of stinging nettle, bladderwrack kelp and Pacific ninebark can all correct function of the mutation- carrying proteins causing a specific form of ataxia." Abbott's research team also found that two compounds contained in these plants, tannic acid and gallic acid, are each able to rescue activity of the EA1-linked mutation-carrying ion channel proteins. "The plant compounds are the first known compounds to rescue the activity of Kv1.1 carrying EA1-linked loss-of-function sequence variants," said Abbott. "Gallic acid in particular is of therapeutic interest because it is already available over the counter as a nutritional supplement and is very well tolerated in toxicity studies." Individuals with ataxia exhibit abnormal gait, slurring, eye movement abnormalities, difficulties with balance and walking, tremors, and disruption of fine motor skills. "These mutations can cause other disorders, including epilepsy, and so there is therapeutic potential for those conditions as well, " said Abbott. "We have discovered that where modern synthetic drug development techniques have failed to produce a drug that directly rescues EA1-linked mutant channel function, traditional botanical medicine developed by North American First Nation peoples has succeeded." Further research is now needed to explore the efficacy of the plant-derived compounds in preclinical and clinical studies. "We have made a mouse model of a relatively severe form of human EA1 so that we can test the efficacy and safety of gallic acid and also whole plant extracts," said Abbott. "If the preclinical studies go well, our goal is to move to clinical trials. Concurrently, we are synthesizing and testing other plant compounds and derivatives to discover other compounds with potential for treating EA1 and related disorders." There are several forms of ataxia, which is an umbrella term describing loss of coordination or balance. Together with Abbott, the research team comprised Drs. Rian Manville, J. Alfredo Freites, Doug Tobias (UC Irvine) and Richard Sidlow (Valley Children's Hospital). This work was supported by the National Institutes of Health and the National Institute of General Medical Sciences.

10 Nov 2022

·www.sciencedaily.com

Smartphones are reservoirs of allergens according to new research

A new study showed elevated levels of cat and dog allergens, as well as BDG and endotoxin on simulated phone models. According to the 2018 U.S. Census, smart phones are present in 85% of American households. They are reportedly viewed 14 million times a day, making them potential receptacles for environmental hazards such as allergens. A new study being presented at this year's American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Louisville, KY, showed elevated levels of cat and dog allergens, as well as β-D glucans (BDG) and endotoxin on simulated phone models. "Smartphones showed elevated and variable levels of BDG and endotoxin, and cat and dog allergens were found on smartphones of pet owners" says Hana Ruran, lead author on the study. "BDGs are found in fungal cell walls and have been found in many environments and surfaces causing chronic airway and irritant symptoms -- making BDGs a consistent marker to study problematic mold. Endotoxin is a potent inflammatory agent and a marker of exposure to Gram negative bacteria." The researchers created phone models that had a similar size and surface to a real phone and the front surface of the phone model was wiped as part of the test. Electrostatic wipes (ESW) were used to sample simulated phone models of 15 volunteers and the "phones" were then measured for allergens, BDG and endotoxin levels. The chemicals used in the mixture solutions for cleaning (chlorhexidine, cetylpyridinium chloride, tannic acid and benzyl benzoate) can be purchased through laboratory or chemical suppliers but are not commercially available in the same concentrations as used in the study. Isopropyl alcohol wipes were also tested for their cleaning properties. "Combination chlorhexidine/cetylpyridinium was the most effective in reducing BDG and endotoxin and combination benzyl benzoate/tannic acid most effectively reduced cat and dog allergens on smartphones," says Peter Thorne, PhD, professor in the University of Iowa Department of Public Health and co-author of the study. "The study demonstrates exposure to inhalant allergens and molecules that trigger innate immune reactions from a source most people haven't considered. If you have allergies or asthma, you may want to think about cleaning your smartphone more often to minimize exposure to these allergens and asthma triggers." Presenter: Hana Ruran

100 Deals associated with Tannic Acid

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


EASD2013	Not Applicable	Insulinoma anoctamin 1	-	Tannic acid	icwwxswjxj(hwddsschku) = lpawpceipp esahvypvdo (uqvabxmymq ) View more	Positive	26 Sep 2013
				Control (no tannic acid)	icwwxswjxj(hwddsschku) = hjwchrdgtc esahvypvdo (uqvabxmymq ) View more

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