Central South University

TUESDAY, Oct. 1, 2024 -- The weight-adjusted waist index (WWI) may be able to predict future incidence of overactive bladder (OAB) in adults, according to a study published online Sept. 3 in Frontiers in Nutrition . Zeng Hui, from the Third Xiangya Hospital at Central South University in Changsha, China, and colleagues used data from the National Health and Nutrition Examination Survey (2009 to 2018; 35,950 individuals) to examine the correlation between WWI and OAB. The researchers found that individuals with a higher WWI had a higher risk for OAB (odds ratio, 1.41). The relationship between WWI and OAB was consistent across various population characteristics. There was a positive nonlinear relationship between WWI and OAB in smoothing curve fitting. The association between WWI and OAB was stronger than with other obesity-related indicators. "In this study, we found a positive relationship between higher WWI levels and an increased risk of OAB," the authors write. "Furthermore, the relationship between WWI and OAB is stronger than the correlation between other obesity markers and OAB, indicating that WWI may serve as a simple anthropometric indicator for predicting OAB." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

FRIDAY, Jan. 26, 2024 -- For women with prenatal depression undergoing cesarean delivery, dexmedetomidine reduces the incidence of positive postpartum depression (PPD) screening, according to a study published online Jan. 25 in JAMA Network Open . Yingyong Zhou, Ph.D., from The Third Xiangya Hospital of Central South University in Changsha, China, and colleagues conducted a randomized clinical trial involving 338 women who screened positive for prenatal depression and were scheduled for elective cesarean delivery at two hospitals to assess the efficacy and safety of dexmedetomidine for prevention of PPD. A total of 338 participants were randomly assigned in a 1:1 ratio to receive dexmedetomidine or saline, infused for 10 minutes after delivery. After infusion, sufentanil or dexmedetomidine plus sufentanil was administered for 48 hours in the control and dexmedetomidine groups, respectively. The researchers found that the incidence of positive PPD screening at seven and 42 days postpartum was significantly reduced in the dexmedetomidine group versus the control group (day 7: 12.6 versus 32.1 percent; risk ratio, 0.39; day 42: 11.4 versus 30.3 percent; risk ratio, 0.38). No significant difference was seen between the groups in terms of adverse events, but an increased incidence of hypotension was seen in the dexmedetomidine group (18.3 versus 9.5 percent; risk ratio, 2.15). "Preventive administration of dexmedetomidine in the early postpartum period reduced the incidence of positive PPD screening, reduced postoperative pain, improved sleep quality, and maintained a favorable safety profile," the authors write. "Its antidepressant effect may be related to brain-derived neurotrophic factor upregulation and/or downregulation of pro-brain-derived neurotrophic factor." Abstract/Full Text Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions. Posted January 2024 More news resources FDA Medwatch Drug Alerts Daily MedNews News for Health Professionals New Drug Approvals New Drug Applications Drug Shortages Clinical Trial Results Generic Drug Approvals Subscribe to our newsletter Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

THURSDAY, Aug. 3, 2023 -- Higher consumption of dietary fiber was associated with a lower risk for inflammatory bowel disease (IBD), according to a study published online July 18 in Alimentary Pharmacology and Therapeutics . Minzi Deng, Ph.D., from Central South University in Changsha, China, and colleagues examined associations between dietary fiber intake and subsequent incidence of IBD, Crohn disease, and ulcerative colitis. The analysis included 470,669 participants from the U.K. Biobank. The researchers found that during an average follow-up of 12.1 years, there was an inverse association between dietary fiber intake and risk for IBD (lowest versus highest quintile: hazard ratio, 0.74; 95 percent confidence interval, 0.58 to 0.93; P = 0.011) and Crohn disease (hazard ratio, 0.48; 95 percent confidence interval, 0.32 to 0.72; P < 0.001). However, no association was seen with ulcerative colitis (hazard ratio, 0.92; 95 percent confidence interval, 0.69 to 1.24; P = 0.595). Dietary fiber intake from fruit and bread was associated with lower risk for Crohn disease, while dietary fiber intake from cereal decreased the risk for ulcerative colitis. "Our findings support current recommendations to increase the intake of dietary fiber," the authors write. "Further studies are needed to obtain more epidemiological evidence from other populations and explore the potential role and mechanisms for specified dietary fiber intake sources in preventing different subtypes and phenotypes of IBD." Abstract/Full Text (subscription or payment may be required) Posted August 2023