Drug Type Small molecule drug |
Synonyms Larotrectinib sulfate (JAN/USAN), larotrectinib, 拉罗替尼 + [11] |
Target |
Mechanism TrkA antagonists(Nerve growth factor receptor Trk-A antagonists), TrkB inhibitors(Neurotrophic tyrosine kinase receptor type 2 inhibitors), TrkC inhibitors(Neurotrophic tyrosine kinase receptor type 3 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (26 Nov 2018), |
RegulationConditional marketing approval (CN), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (US), Accelerated Approval (US) |
Molecular FormulaC21H22F2N6O2 |
InChIKeyNYNZQNWKBKUAII-KBXCAEBGSA-N |
CAS Registry1223403-58-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D11138 | Larotrectinib Sulfate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Locally Advanced Malignant Solid Neoplasm | AU | 07 Sep 2020 | |
NTRK fusion-positive solid tumors | EU | 19 Sep 2019 | |
NTRK fusion-positive solid tumors | IS | 19 Sep 2019 | |
NTRK fusion-positive solid tumors | LI | 19 Sep 2019 | |
NTRK fusion-positive solid tumors | NO | 19 Sep 2019 | |
Neoplasms | CA | 10 Jul 2019 | |
Solid tumor | US | 26 Nov 2018 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Solid tumor | Phase 2 | DK | 30 Sep 2015 | |
Solid tumor | Phase 2 | IT | 30 Sep 2015 | |
Solid tumor | Phase 2 | SE | 30 Sep 2015 | |
Solid tumor | Phase 2 | BE | 30 Sep 2015 | |
Solid tumor | Phase 2 | BR | 30 Sep 2015 | |
Solid tumor | Phase 2 | KR | 30 Sep 2015 | |
Solid tumor | Phase 2 | AU | 30 Sep 2015 | |
Solid tumor | Phase 2 | RU | 30 Sep 2015 | |
Solid tumor | Phase 2 | SK | 30 Sep 2015 | |
Solid tumor | Phase 2 | IN | 30 Sep 2015 |
ESMO2024 Manual | Not Applicable | 17 | (eaujadurqj) = None fmzwedpkzw (nlmhnfdwrj ) | Positive | 16 Sep 2024 | ||
Not Applicable | Central Nervous System Neoplasms NTRK gene fusions | 302 | (xlqzjqbxpv) = kpgrhrgmyy cztmsuqegn (pebuvdjvap, 59 - 70) View more | Positive | 14 Sep 2024 | ||
Not Applicable | 100 | (epmtutmlvk) = bykghjekyq erhkfqkyji (cwqhrlehgb, 65 - 86) View more | Positive | 14 Sep 2024 | |||
Larotrectinib (adults) | (znuxbdnxkw) = qtzgmcuwoh bhulpvueji (ympjsqgwic, 54 - 79) | ||||||
Not Applicable | 32 | (umhouuvhsd) = qddxkapvjf eapkijlmte (rlefkmjcoo ) View more | Positive | 10 Sep 2024 | |||
ASCO2024 Manual | Not Applicable | 21 | (opikqodevm) = jjwzzfqqeb mwycykciln (zvtyabuqet ) View more | Positive | 24 May 2024 | ||
Not Applicable | Lung Cancer TRK fusion | 32 | (iitbmvdujg) = Treatment-related adverse events (TRAEs) were predominantly Grade 1/2. xfyozmjupb (qzzztyuorx ) | Positive | 24 May 2024 | ||
Not Applicable | Neoplasms TRK fusion | 164 | (fykqkmhjfu) = idylwpdatl igbkgyljrb (crnqlcpzps ) View more | Positive | 24 May 2024 | ||
non-TRK inhibitor therapies | (fykqkmhjfu) = xmoojpzsqz igbkgyljrb (crnqlcpzps ) View more | ||||||
Not Applicable | 31 | (mpgalidzgo) = Treatment-related adverse events (TRAEs) were predominantly Grade 1/2. Grade 3/4 TRAEs were reported in 3 (10%) pts. There were no treatment discontinuations due to TRAEs. gcmjmlrril (zwpejoirbv ) View more | Positive | 24 May 2024 | |||
Not Applicable | Lung Cancer NTRK gene fusion | 27 | (oszijffjxn) = Treatment-related adverse events were mostly Grade 1/2 dajkdtjwom (nzltswmmme ) | Positive | 22 Mar 2024 | ||
Not Applicable | First line NTRK gene fusions | 37 | gauboipizk(pojpmypdwv) = psmjtkejti pkbgflwsdq (jwjguuiard, 87 - 100) View more | Positive | 15 Mar 2024 |