FGFRs antagonists(Fibroblast growth factor receptors antagonists), FLT3 inhibitors(Tyrosine-protein kinase receptor FLT3 inhibitors), HPK1 inhibitors(Mitogen-activated protein kinase kinase kinase kinase 1 inhibitors)

+ [3]

Therapeutic Areas

NeoplasmsDigestive System DisordersHemic and Lymphatic Diseases+ [2]

Active Indication

Advanced gastric carcinomaColorectal CancerMyelodysplastic Syndromes+ [3]

Inactive Indication

Advanced Colorectal AdenocarcinomaAdvanced Gastric AdenocarcinomaGastrooesophageal junction cancer+ [3]

Originator Organization

Guangzhou Zaiji Medical Technology Co., Ltd.

Active Organization

Guangzhou Zaiji Medical Technology Co., Ltd.

Inactive Organization

Maxinovel Pty., Ltd.

Drug Highest PhasePhase 2

First Approval Date-

RegulationSpecial Review Project (CN), Orphan Drug (US)

Structure

Molecular FormulaC22H23FN6OS

InChIKeyAVIOBQFPAGEICQ-UHFFFAOYSA-N

CAS Registry2070931-57-4

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB15191

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced gastric carcinoma	Phase 2	CN	Guangzhou Zaiji Medical Technology Co., Ltd.	25 Jun 2022
Colorectal Cancer	Phase 2	CN	Guangzhou Zaiji Medical Technology Co., Ltd.	29 Nov 2021
Refractory acute myeloid leukemia	Phase 2	CN	Maxinovel Pty., Ltd.	16 Sep 2021
Relapsing acute myeloid leukemia	Phase 2	CN	Maxinovel Pty., Ltd.	16 Sep 2021
Myelodysplastic Syndromes	Phase 2	CN	Guangzhou Zaiji Medical Technology Co., Ltd.	09 Sep 2021
Advanced Gastric Adenocarcinoma	Phase 1	CN	Maxinovel Pty., Ltd.	01 Jun 2022
Gastrooesophageal junction cancer	Phase 1	CN	Maxinovel Pty., Ltd.	01 Jun 2022
Advanced Colorectal Adenocarcinoma	Phase 1	CN	Maxinovel Pty., Ltd.	31 Jan 2022
Metastatic Colorectal Carcinoma	Phase 1	CN	Maxinovel Pty., Ltd.	31 Jan 2022
Acute Myeloid Leukemia	Phase 1	AU	Maxinovel Pty., Ltd.	01 Aug 2018

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Company_Website Manual	Phase 1	Acute Myeloid Leukemia FLT3野生型	-	MAX-40279+阿扎胞苷	(otibdqdcsa) = nltewvydqk ttbohvyath (vvhuzsueku ) View more	Positive	01 Oct 2023

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