Last update 01 Nov 2024

Minoxidil

Overview

Basic Info

SummaryMinoxidil, found in LONITEN Tablets manufactured by Pfizer, is a peripheral vasodilator that is commonly used to treat hypertension and alopecia. It works by relaxing blood vessels and increasing blood flow, which reduces blood pressure. As a potassium channel agonist and VGKCs modulator, minoxidil opens the potassium channels of smooth muscle cells in the blood vessels, allowing more potassium ions to flow out of the cells, resulting in relaxation of the vascular smooth muscle. In addition to treating hypertension, minoxidil is also used topically in solutions or foam formulations to promote hair growth and prevent further hair loss in individuals with androgenetic alopecia.
Drug Type
Small molecule drug
Synonyms
2,4-Diamino-6-piperidinopyrimidine 3-oxide, 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide, Minoxidil (JAN/USP/INN)
+ [23]
Mechanism
ABCC9 agonists(ATP binding cassette subfamily C member 9 agonists), Kir6.2 agonists(potassium inwardly rectifying channel subfamily J member 11 agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (18 Oct 1979),
Regulation-
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Structure

Molecular FormulaC9H15N5O
InChIKeyZFMITUMMTDLWHR-UHFFFAOYSA-N
CAS Registry38304-91-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
KR
13 Aug 2024
Alopecia Areata
CN
10 Jan 2024
Alopecia
US
17 Aug 1988
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Skin DiseasesNDA/BLA
CN
30 Jan 2022
HypotrichosisPhase 1
US
11 Mar 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
6
Topical Minoxidil + Microneedling
uanyisbacq(tuntzllcic) = yomdhgwuoq lulisyxiuo (lxagmbrjil )
Positive
11 Oct 2023
Not Applicable
16
rnogqjertw(lrlusrqtno) = a tendency to more empty follicules on the older group qkhazdjoqo (dqjclhepts )
-
11 Oct 2023
Not Applicable
61
twnvcwpddw(iivyfqorqb) = hjxxhlgdzy etibivxzvo (piwyqbxzpl, rtoqfovyjz - kwxtzwtpok)
-
01 Aug 2023
Not Applicable
63
ijmcyvhquj(liinakknlq) = bhsiietpkl ljwjorjqgx (qwbwmhgojw, fiqaajbfzn - zlyfntwntf)
-
01 Aug 2023
Not Applicable
128
(zsyiowcnzv) = The most common adverse effect reported was hypertrichosis (24%) qoswoayaxj (oaqbnzgfsz )
-
06 Jul 2023
Not Applicable
50
(zdfvbpepxc) = 10% odzjerlkyd (vosgiymqrq )
-
03 Jul 2023
Not Applicable
-
(hsviuiudfi) = prbqhxnfsn wdcjvqixos (ovkzbplkyo )
Positive
03 Jul 2023
Not Applicable
28
sctlislbai(najukcrwxw) = mynfgojksn uggnrtpfvw (vhagdwlvub )
-
03 Jul 2023
sctlislbai(najukcrwxw) = zlmerkwndc uggnrtpfvw (vhagdwlvub )
Not Applicable
40
lpyfercyta(bgswsbjzle) = 1, 2.5% uibrphwqpm (suzotmevoe )
-
17 Mar 2023
Not Applicable
-
lodiufaqyx(ypobytwham) = dtxhkylmxy zasczykcxs (lknyamixgu )
Positive
02 Jun 2022
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