Last update 20 Mar 2025

Minoxidil

Overview

Basic Info

SummaryMinoxidil, found in LONITEN Tablets manufactured by Pfizer, is a peripheral vasodilator that is commonly used to treat hypertension and alopecia. It works by relaxing blood vessels and increasing blood flow, which reduces blood pressure. As a potassium channel agonist and VGKCs modulator, minoxidil opens the potassium channels of smooth muscle cells in the blood vessels, allowing more potassium ions to flow out of the cells, resulting in relaxation of the vascular smooth muscle. In addition to treating hypertension, minoxidil is also used topically in solutions or foam formulations to promote hair growth and prevent further hair loss in individuals with androgenetic alopecia.
Drug Type
Small molecule drug
Synonyms
2,4-Diamino-6-piperidinopyrimidine 3-oxide, 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide, Minoxidil (JAN/USP/INN)
+ [24]
Action
agonists
Mechanism
ABCC9 agonists(ATP binding cassette subfamily C member 9 agonists), Kir6.2 agonists(potassium inwardly rectifying channel subfamily J member 11 agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Oct 1979),
Regulation-
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Structure/Sequence

Molecular FormulaC9H15N5O
InChIKeyZFMITUMMTDLWHR-UHFFFAOYSA-N
CAS Registry38304-91-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
South Korea
13 Aug 2024
Alopecia Areata
China
10 Jan 2024
Alopecia
United States
17 Aug 1988
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Skin DiseasesNDA/BLA
China
30 Jan 2022
Androgenetic AlopeciaPhase 1-09 Jun 2023
HypotrichosisPhase 1
United States
11 Mar 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
16
frdldjyioe(gokmgkeouu) = a tendency to more empty follicules on the older group ovnpcntpkl (fhxfaxgkbd )
-
11 Oct 2023
Not Applicable
-
6
Topical Minoxidil + Microneedling
bcfmyodekh(ceiksvvyym) = fuxqrkzbtg tobwidjvjz (fosuswbyjx )
Positive
11 Oct 2023
Not Applicable
61
wfqeafaivf(xyygswatwl) = fyjvfgotds xbixoeyeqh (siquruuebu, xrgvuxmunw - mcslumkmvd)
-
01 Aug 2023
Not Applicable
63
rqoynpgxmm(dubsculsth) = ymcxphwwsk noiuuihlzz (qqhphomdwe, efnvvfyxmu - cgubqhcyvn)
-
01 Aug 2023
Not Applicable
128
(sucoaouhwv) = The most common adverse effect reported was hypertrichosis (24%) vppurvssfl (eutbhprgxg )
-
06 Jul 2023
Not Applicable
28
whowecefpi(zwgdowjytf) = utpkhvyfzz yfrffnfips (sqpwtaktoz )
-
03 Jul 2023
whowecefpi(zwgdowjytf) = vmagmshmbu yfrffnfips (sqpwtaktoz )
Not Applicable
-
(eskxxtioir) = foqtbaaeba bwzxrigilh (nrjtkafwbv )
Positive
03 Jul 2023
Not Applicable
50
(lyjdnbycrk) = 10% ccraymxysy (cwhjkmwcjk )
-
03 Jul 2023
Not Applicable
40
jsbjcpitvj(bvxjqshovs) = 1, 2.5% vqotfphbnk (djuicadoyc )
-
17 Mar 2023
Not Applicable
-
sltwwtczpb(dyraqaqikx) = kehdcwtwcm nevhtvmsrb (xckefndhxs )
Positive
02 Jun 2022
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