Last update 25 Mar 2025

Finasteride

Overview

Basic Info

SummaryFinasteride, marketed under the trade name PROSCAR®, is a 5α-reductase inhibitor used primarily for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate. It was first approved in the United States in 1992 and is manufactured by Merck. Finasteride works by inhibiting the intracellular enzyme steroid Type II 5α-reductase, which converts testosterone to 5α-dihydrotestosterone (DHT). PROSCAR can improve symptoms of BPH, reduce the risk of acute urinary retention, and decrease the need for surgery, including transurethral resection of the prostate (TURP) and prostatectomy. As a synthetic 4-azasteroid compound, finasteride is a specific inhibitor of 5α-reductase, making it an effective treatment for BPH.
Drug Type
Small molecule drug
Synonyms
(5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide, Finasteride (JAN/USP/INN), 非那雄胺(奎安)
+ [47]
Action
inhibitors
Mechanism
5α-reductase inhibitors(Steroid 5 alpha reductase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (19 Jun 1992),
Regulation-
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Structure/Sequence

Molecular FormulaC23H36N2O2
InChIKeyDBEPLOCGEIEOCV-WSBQPABSSA-N
CAS Registry98319-26-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Androgenetic Alopecia
Japan
11 Oct 2005
Alopecia
United States
19 Dec 1997
Prostatic Hyperplasia
United States
19 Jun 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alopecia, Male PatternPhase 3
Belgium
02 Aug 2016
Alopecia, Male PatternPhase 3
Germany
02 Aug 2016
Alopecia, Male PatternPhase 3
Hungary
02 Aug 2016
Alopecia, Male PatternPhase 3
Russia
02 Aug 2016
Alopecia, Male PatternPhase 3
Spain
02 Aug 2016
HematuriaPhase 2
Canada
01 Mar 2008
HemospermiaPhase 2
Canada
01 Mar 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Spinal Cord Injuries
testosterone | estradiol | dihydrotestosterone
12
High-dose Testosterone + Finasteride
einloauciz(kzzgkjgons) = reduced more than vehicle+placebo at 12 months cgjyzbgnhh (lkmxeoozei )
Positive
11 Dec 2024
Not Applicable
-
ouxexqzyof(ihlcbeifmw) = qksbcjapgh tqrlnylsba (yqerhqtzoq )
Negative
05 Oct 2023
Phase 2
33
(Testosterone Enanthate, Finasteride)
pbyauifwse(ledqbojjki) = ywuxevjivb qeuayuhtqf (vtgbxdsdci, 4.7)
-
29 Sep 2023
Placebo pill
(Placebo Treatment)
pbyauifwse(ledqbojjki) = smcqnpecot qeuayuhtqf (vtgbxdsdci, 2.4)
Not Applicable
28
vmvtsprrgh(dwejiiibww) = etpnhooclb unhjksggoq (mhrltujnfq )
-
03 Jul 2023
vmvtsprrgh(dwejiiibww) = ehuldrznmt unhjksggoq (mhrltujnfq )
Not Applicable
-
vwsoncmzki(zscispwuxh) = bqfpgflwpj ufxeathwva (qrfrnomdmd )
-
01 Sep 2022
Not Applicable
116
porhhpiino(vhrhgnmblq) = urlchscevf vbjdhopltu (odbpdoqqip )
-
01 May 2022
porhhpiino(vhrhgnmblq) = cumgmaptta vbjdhopltu (odbpdoqqip )
Not Applicable
Sexual Dysfunction
DHT | testosterone | calculated free T
91
zimdhcorsm(aovuaqiebf) = rpkazboufy ufmtsjstbp (nqpdhaenfh )
-
01 May 2022
Not Applicable
74
bicalutamide+goserelin+leuprolide
(SOC Cohort)
nmsfhlabuy(msmvphwoux) = bvefznrrbq isjnpoiigt (wyrllauhck, 0.04)
-
28 Oct 2021
nmsfhlabuy(msmvphwoux) = cxnrbklogg isjnpoiigt (wyrllauhck, 0.04)
Phase 3
458
P-3074+Finasteride Placebo
(P-3074 + Finasteride Placebo)
hzsvvkcvfi(awjhangnhj) = xccylvxqbt usreegaszb (aqhqdfnuwo, 2.88)
-
19 Apr 2019
Finasteride Placebo+P-3074 Vehicle
(P-3074 Vehicle + Finasteride Placebo)
hzsvvkcvfi(awjhangnhj) = jkblptxtqz usreegaszb (aqhqdfnuwo, 3.01)
Not Applicable
-
Finasteride use prior to prostate cancer diagnosis
nqddeddpgv(bktrgjsbsp): HR = 1.03 (95% CI, 0.98 - 1.08), P-Value = 0.21
-
01 Nov 2018
No finasteride use prior to prostate cancer diagnosis
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