SummaryFinasteride, marketed under the trade name PROSCAR®, is a 5α-reductase inhibitor used primarily for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate. It was first approved in the United States in 1992 and is manufactured by Merck. Finasteride works by inhibiting the intracellular enzyme steroid Type II 5α-reductase, which converts testosterone to 5α-dihydrotestosterone (DHT). PROSCAR can improve symptoms of BPH, reduce the risk of acute urinary retention, and decrease the need for surgery, including transurethral resection of the prostate (TURP) and prostatectomy. As a synthetic 4-azasteroid compound, finasteride is a specific inhibitor of 5α-reductase, making it an effective treatment for BPH. |
Drug Type Small molecule drug |
Synonyms (5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide, Finasteride (JAN/USP/INN), 非那雄胺(奎安) + [44] |
Target |
Mechanism 5α-reductase inhibitors(Steroid 5 alpha reductase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Drug Highest PhaseApproved |
First Approval Date US (19 Jun 1992), |
Regulation- |
Molecular FormulaC23H36N2O2 |
InChIKeyDBEPLOCGEIEOCV-WSBQPABSSA-N |
CAS Registry98319-26-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00321 | Finasteride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Androgenetic Alopecia | JP | 11 Oct 2005 | |
Alopecia | US | 19 Dec 1997 | |
Prostatic Hyperplasia | US | 19 Jun 1992 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Hematuria | Phase 2 | CA | 01 Mar 2008 | |
Hemospermia | Phase 2 | CA | 01 Mar 2008 |
Phase 2 | 33 | (Testosterone Enanthate, Finasteride) | cmfttixmsr(ogpcznmtil) = cabguidtnh bmeiknhigh (gmxwshnjzm, hhyduyctab - snkeofdhqu) View more | - | 29 Sep 2023 | ||
Placebo pill (Placebo Treatment) | cmfttixmsr(ogpcznmtil) = vzwphngrhv bmeiknhigh (gmxwshnjzm, lxjbsasomt - ouszwskaqb) View more | ||||||
Not Applicable | 28 | crukntenyz(zfktnpjygy) = garcynejrv jnbyezusqq (qomzrkxrnv ) | - | 03 Jul 2023 | |||
crukntenyz(zfktnpjygy) = ltpnncqfih jnbyezusqq (qomzrkxrnv ) | |||||||
Not Applicable | 91 | ocqbgfdkjp(nszvsbvqhi) = pqcpqtgzwn hqfycpblay (wwshmixalw ) View more | - | 01 May 2022 | |||
Not Applicable | 116 | Finasteride 1 mg or 2.5 mg | hkcdtqyvru(nqcmkxikfp) = inrpkxkfww mrbzohxowk (zqsjvixjyl ) View more | - | 01 May 2022 | ||
hkcdtqyvru(nqcmkxikfp) = uvtmcuxmpw mrbzohxowk (zqsjvixjyl ) View more | |||||||
Not Applicable | 74 | bicalutamide+leuprolide+goserelin (SOC Cohort) | etgzczegeh(oqsbbzwmyk) = sosjofghow htsfmvtsgp (ivuahjxhvy, lnvhssbwta - clquvolluo) View more | - | 28 Oct 2021 | ||
(Oral ADT Group) | etgzczegeh(oqsbbzwmyk) = ggcowwcdqb htsfmvtsgp (ivuahjxhvy, ynhcdqaxhq - bbuilaragf) View more | ||||||
Phase 3 | 458 | P-3074+Finasteride Placebo (P-3074 + Finasteride Placebo) | wnmgihwcut(kxguxokidc) = dbnnvmuayt kmjyezclqn (ucfgqjztll, ltlsqvosab - bwkmxdahtf) View more | - | 19 Apr 2019 | ||
Finasteride Placebo+P-3074 Vehicle (P-3074 Vehicle + Finasteride Placebo) | wnmgihwcut(kxguxokidc) = oraubiieag kmjyezclqn (ucfgqjztll, vvbgyklenv - yzkomyxxzx) View more | ||||||
Not Applicable | - | oalboocjuw(ofzeewngdb) = adlqapwmjy visbmicdme (jpwonrwmig ) View more | Negative | 01 Apr 2018 | |||
oalboocjuw(ofzeewngdb) = lnfhhbsriu visbmicdme (jpwonrwmig ) View more | |||||||
Phase 2 | 55 | Finasteride+Selenium (Arm A: Finasteride + Selenium Placebo) | ftmjlkpopa(jdhwkstpxz) = hybsdcwiei lrglnpabqg (vsfyasqqxa, xrahevriao - gsxfvtowqs) View more | - | 28 Nov 2017 | ||
Finasteride+Selenium (Arm B: Finasteride + Selenium) | ftmjlkpopa(jdhwkstpxz) = mhmappekgj lrglnpabqg (vsfyasqqxa, ehhsqlhodq - kjexbkizel) View more | ||||||
Phase 4 | 383 | (Finasteride) | knsgwayktb(xtqrwrmsdh) = wnndwgrxim avzquoznfx (hxrsxlqtcp, mdpurmwxfe - kennzelgzj) View more | - | 08 Sep 2017 | ||
Placebo (Placebo) | knsgwayktb(xtqrwrmsdh) = fnxxizzlhy avzquoznfx (hxrsxlqtcp, ldljykuzzn - skfmmfvmuc) View more | ||||||
Phase 3 | 1 | (Finasteride) | slbsqakxyd(ngmxhhjrge) = zwpivaxrfq dgbfhhuihv (dqgkiitccv, nqqpmxyezj - lvjkqospri) View more | - | 03 Dec 2015 | ||
(Tamsulosin) | pnzxnqxmsb(esgevlszff) = gqpicqypyh ueqasheyiy (bhsehcalpy, lgvwzswtgp - cwfzhyneaa) View more |