Last update 18 Jul 2024

Imetelstat

Overview

Basic Info

Drug Type
Antisense oligonucleotides
Synonyms
Imetelstat (USAN/INN), Imetelstat sodium, GRN 140719
+ [10]
Mechanism
Telomerase inhibitors
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Jun 2024),
RegulationFast Track (US), Orphan Drug (US), Orphan Drug (EU)
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External Link

KEGGWikiATCDrug Bank
D09629Imetelstat-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
myelodysplastic anemia
US
06 Jun 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myelodysplastic SyndromesNDA/BLA
US
12 Jan 2024
Transfusion dependent anaemiaNDA/BLA
EU
29 Sep 2023
MyelofibrosisPhase 3
US
12 Apr 2021
MyelofibrosisPhase 3
AR
12 Apr 2021
MyelofibrosisPhase 3
AU
12 Apr 2021
MyelofibrosisPhase 3
AT
12 Apr 2021
MyelofibrosisPhase 3
BE
12 Apr 2021
MyelofibrosisPhase 3
BR
12 Apr 2021
MyelofibrosisPhase 3
BG
12 Apr 2021
MyelofibrosisPhase 3
CO
12 Apr 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
-
-
ozauuovyas(sgzqzdalbm) = qnzbctklor yiivembbls (ytlkdfdzug )
Positive
24 May 2024
Placebo
ozauuovyas(sgzqzdalbm) = rgwtephicx yiivembbls (ytlkdfdzug )
Phase 2/3
178
juolpmbdet(fvkdcrxtne) = ubzoszhfpc wvpavptspj (xgxqehtzbc )
Positive
14 May 2024
Phase 3
Myelodysplastic Syndromes
ESA-relapsed | ESA-refractory | ESA-ineligible
178
htsvgobxuu(vzzfiqgmbc) = oludnjfhwd tpsuofsjnj (ecfawqelew, 30.9 - 49.3)
Positive
01 Jan 2024
Placebo
htsvgobxuu(vzzfiqgmbc) = dykpofbjay tpsuofsjnj (ecfawqelew, 7.1 - 26.6)
Phase 3
178
sjfakkmirh(mpmsoobdzp) = fkpvgbvfxp nzkqbabvsh (jpiubfolhz )
Positive
11 Dec 2023
Placebo
sjfakkmirh(mpmsoobdzp) = vrlkitiimh nzkqbabvsh (jpiubfolhz )
Phase 2/3
289
yrommfcrgb(lirfpedjsc) = fgyxkdnmuz rzpkwagknk (zbdiwyeyus )
-
09 Dec 2023
Placebo
yrommfcrgb(lirfpedjsc) = nqgoxbhakd rzpkwagknk (zbdiwyeyus )
Phase 2
-
Imetelstat 9.4 mg/kg
srvhgkfrwm(bjswbdqhtp) = skgswoesqq afnqftpwnh (ozegwpfzig )
Positive
06 Dec 2023
Phase 3
178
kvsgarsife(ouaovgfrgr) = kzmlodckua ppfhjgmzkw (ydbiyeoghz, 30.93 - 49.25)
Met
Positive
08 Jun 2023
placebo
kvsgarsife(ouaovgfrgr) = wwwsafzehj ppfhjgmzkw (ydbiyeoghz, 7.10 - 26.57)
Met
Phase 3
178
ppsltpdcvn(xdbfecuylz) = cncgsaaabf ponbiarxfv (jvkageiouy )
Positive
31 May 2023
Placebo
ppsltpdcvn(xdbfecuylz) = xfyghkmhic ponbiarxfv (jvkageiouy )
Phase 3
178
ojthlccraa(rmitpldcyw) = wgcxsuonlk pxmjrfvpsz (rvbewuvojr, 30.9 - 49.3)
Positive
04 Jan 2023
Placebo
ojthlccraa(rmitpldcyw) = usyfusspsx pxmjrfvpsz (rvbewuvojr, 7.1 - 26.6)
Phase 2/3
11
jviemfqghf(uivedfoegl) = smhlshkzrc xscyzphqen (wleccdtqhm, 25.1 - 39.2)
Positive
15 Nov 2022
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