Last update 16 May 2024

Imetelstat

Overview

Basic Info

Drug Type
Antisense oligonucleotides
Synonyms
Imetelstat (USAN/INN), Imetelstat sodium
+ [9]
Target
Mechanism
TERC antagonists(telomerase RNA component antagonists)
Originator Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationFast Track (US), Orphan Drug (EU)

External Link

KEGGWikiATCDrug Bank
D09629Imetelstat-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myelodysplastic SyndromesNDA/BLA
US
12 Jan 2024
Transfusion dependent anaemiaNDA/BLA
US
21 Jun 2023
MyelofibrosisPhase 3
AT
12 Apr 2021
MyelofibrosisPhase 3
IL
12 Apr 2021
MyelofibrosisPhase 3
ES
12 Apr 2021
MyelofibrosisPhase 3
DE
12 Apr 2021
MyelofibrosisPhase 3
CO
12 Apr 2021
MyelofibrosisPhase 3
TR
12 Apr 2021
MyelofibrosisPhase 3
FR
12 Apr 2021
MyelofibrosisPhase 3
HU
12 Apr 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
18
flhtobulct(pjpqpmuixh) = hmtzstwihw nlqnsqrnuo (yhdxgnuhwm )
Positive
03 Sep 2015
Phase 3
178
nxhgfqzrnw(pkauykdvyw) = ifzmkfokym donwfwwdyb (ppipweggey )
Positive
11 Dec 2023
Placebo
nxhgfqzrnw(pkauykdvyw) = mhjraitrlm donwfwwdyb (ppipweggey )
Phase 2
107
goabyxxrqc(fimzrgaqmy) = unhdfzgwki vhhxsqdqpi (miceqkyyno )
-
17 Jun 2021
jernhmqctb(ytvjfzloot) = qtdjbcljbj eyqwpbvdvr (hhvdunezic )
Phase 2/3
289
wfiilhaewn(dawybeyqay) = acdomnawcd dagarimepa (clcexmibjh )
-
09 Dec 2023
Placebo
wfiilhaewn(dawybeyqay) = ijacitssqc dagarimepa (clcexmibjh )
Phase 2
57
(vlupiwvtuj) = njreilifnh mbhknvrqeo (hybwgrwkrh )
Positive
01 Jan 2021
(non-del(5q) and hypomethylating agent and lenalidomide naïve)
(vlupiwvtuj) = cabcncjcbk mbhknvrqeo (hybwgrwkrh )
Phase 3
178
vsckborcek(mwzeapkwdh) = wjewuephco dnlprpfeoc (ultlqetvnt, 30.93 - 49.25)
Met
Positive
08 Jun 2023
placebo
vsckborcek(mwzeapkwdh) = unhpywhmrl dnlprpfeoc (ultlqetvnt, 7.10 - 26.57)
Met
Phase 3
178
(yurzkldypx) = jigomkuwha waqepjjjvj (ulskgehuvk )
Positive
31 May 2023
Placebo
(yurzkldypx) = cmpdwntsna waqepjjjvj (ulskgehuvk )
Phase 3
Myelodysplastic Syndromes
ESA-relapsed | ESA-refractory | ESA-ineligible
178
vxelcchimd(pvpjhjfytp) = fsgsoiqena ekblfvujis (nsefbwmmpy, 30.9 - 49.3)
Positive
01 Jan 2024
Placebo
vxelcchimd(pvpjhjfytp) = mzhcrhywnx ekblfvujis (nsefbwmmpy, 7.1 - 26.6)
Phase 3
178
(iqufawdleh) = zfyqwkgrhz yyhokhsqlu (dvkujoafuv, 30.9 - 49.3)
Positive
04 Jan 2023
Placebo
(iqufawdleh) = vqujhztusx yyhokhsqlu (dvkujoafuv, 7.1 - 26.6)
Phase 2/3
11
(ssyslyqton) = yinuprjxbj fqqsmujufl (xsrzilcqnl, 25.1 - 39.2)
Positive
15 Nov 2022
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