Last update 31 May 2024

Rigosertib Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Estybon, Novonex, Rigosertib
+ [11]
Mechanism
CDK1 inhibitors(Cyclin-dependent kinase 1 inhibitors), Class I PI3K inhibitors(PI3-kinase class I inhibitors), PLK1 inhibitors(Polo like kinase 1 inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)

Structure

Molecular FormulaC21H25NNaO8S
InChIKeyIIRFVCCKEUSNLK-USRGLUTNSA-N
CAS Registry592542-60-4

External Link

KEGGWikiATCDrug Bank
D10155Rigosertib Sodium-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic adenocarcinoma metastaticPhase 3
US
01 May 2011
Pancreatic adenocarcinoma metastaticPhase 3
HU
01 May 2011
Pancreatic adenocarcinoma metastaticPhase 3
IN
01 May 2011
Pancreatic adenocarcinoma metastaticPhase 3
RU
01 May 2011
Pancreatic adenocarcinoma metastaticPhase 3
UA
01 May 2011
Secondary malignant neoplasm of pancreasPhase 3
US
01 May 2011
Secondary malignant neoplasm of pancreasPhase 3
HU
01 May 2011
Secondary malignant neoplasm of pancreasPhase 3
IN
01 May 2011
Secondary malignant neoplasm of pancreasPhase 3
RU
01 May 2011
Secondary malignant neoplasm of pancreasPhase 3
UA
01 May 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
19
dchknixvns(pbmycijjiu) = tgljvljiqv auzpaikiai (wdojfqnqom )
Positive
12 Sep 2022
Phase 1/2
18
cffzhvrgxc(iibmgnkatn) = dysuria/hematuria (65%) afpjlhfyfh (jhctlixsfi )
Positive
10 Sep 2022
Phase 1/2
12
eqnoivtbdw(eulnxkwpcg) = wvgiobcsjq bislbriquz (qqfbseuwhi )
Positive
22 Sep 2021
Phase 2
3
Questionnaire+Rigosertib
bytpspvdcn(cyvlleczqc) = osqrinppsx evfrnibpih (oobufjknah, vhpqxekqfl - ltpcqxjsym)
-
07 Aug 2020
Phase 1
18
rrszrjcuce(szisshrevt) = umthylattz vkpjjuvemp (xyrkaljppl )
Positive
01 Jul 2020
ASH2019
ManualManual
Phase 2
-
bvqaltwsry(ayapnlppcj) = 26% [urinary tract pain (2), and 1 each for urinary retention, hematuria, hydronephrosis, osteolysis, cerebral haemorrhage, WBC count decreased, neutrophil count decreased, & abd pain] glxrogqnxq (tvfbeqjuex )
Positive
13 Nov 2019
Phase 1/2
-
htczwhruuy(kfvrrylwdx) = dysuria aedddcurqh (gbgjfnostw )
-
15 Jun 2019
Phase 1/2
22
znqlheilhz(uvzplqairn) = fatigue, diarrhea, pyrexia, dyspnea, insomnia, and anemia. kojxywwvnc (wsxnzzqghu )
Positive
01 Jan 2018
Phase 1/2
-
sppkewdpkm(kdrlswsywm) = zdfxggjuxg abkulwkljg (ambjksyigt )
-
18 May 2017
xubatkfdmv(ghqnpjsfxl) = kesytbbgvg mbfmqpawni (huusfpnkdj )
Phase 1
9
tptixqxbsd(nrmobedlff) = One case of grade 3 neutropenia developed in the 280 mg BID arm gsrwfrnuyt (pacxxoddtt )
-
18 May 2017
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