A Prospective, Multi-center, Open, Randomized Clinical Study in Parallel Groups, for the Comparative Evaluation of Efficacy and Safety of Angal, Lozenges [Menthol], 1 mg + 5 mg (Sandoz d.d., Slovenia), and ANTI-ANGIN® FORMULA, Lozenges, 0,2 mg + 2 mg + 50 mg (LLC "Valeant", Russia) in Treatment of Patients With Uncomplicated Acute Infectious and Inflammatory Diseases of the Pharynx, Accompanied by a Sore Throat.

The purpose of this study was to evaluate no less therapeutic efficacy and safety of the Angal, lozenges [Menthol], 1 mg + 5 mg (Sandoz dd, Slovenia) compared to ANTI-ANGIN® FORMULA, lozenges, 0,2 mg + 2 mg + 50 mg (LLC "Valeant", Russia) in treatment of patients with uncomplicated acute infectious and inflammatory diseases of the pharynx, accompanied by a sore throat.

Start Date22 Feb 2017

Sponsor / Collaborator

Sandoz AG

NCT00707902

/ CompletedPhase 3

Multicentric Randomized Double Blind Double Dummy Placebo Controlled Clinical Trial for Assessment of Safety and Efficacy of a Echinacea/Sage Spray in Comparison to a Chlorhexidine/Lidocaine Spray in the Treatment of Acute Sore Throats

The aim of the study is to show non-inferiority of an echinacea/sage spray compared to a chlorhexidine/lidocaine-spray in the treatment of acute sore throat during five days of treatment.
Main outcome parameter is the non-inferiority in number of responders between the two treatment groups. A responder is defined as a reduction by 50% of the total baseline score taken prior to treatment start. The symptoms are assessed with a symptom score.

Start Date01 Feb 2006

Sponsor / Collaborator

A. Vogel AG

100 Clinical Results associated with Chlorohexide/Lidocaine

100 Translational Medicine associated with Chlorohexide/Lidocaine

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01 Apr 2020·3 BiotechQ4 · ENGINEERING & TECHNOLOGY

Quantification of 3,6-anhydro-galactose in red seaweed polysaccharides and their potential skin-whitening activity

Q4 · ENGINEERING & TECHNOLOGY

Article

Author: Zhang, Xiao ; Cheong, Kit-Leong ; Liu, Yang ; Chen, Xian-Qiang ; Xie, Xu-Ting

This study determined the composition of the monosaccharide, 3, 6-anhydrogalactose (AnGal), in red algae and explored the potential whitening activity of the extract. Using gas chromatography-mass spectrometry (GC-MS), the AnGal composition of six different species of red seaweed (Porphyra haitanensis, Gracilaria chouae, Gracilaria blodgettii, Gracilaria lemaneiformis, Eucheuma galetinae, and Gelidium amansii) was successfully analyzed, revealing molar ratios ranging from 1.0:1.0 to 1.0:3.1 of AnGal and galactose (Gal), respectively. Employing the tyrosinase inhibition assay, the skin-whitening effect of AnGal red seaweed polysaccharides was determined. Polysaccharides from P. haitanensis, G. chouae, and G. blodgettii as well as their degradation products showed higher tyrosinase inhibitory activity (inhibition rates 24.2-26.8%). These results suggest that the GC-MS approach could conveniently be used in quality control or for the quantitative determination of AnGal and Gal in red seaweed polysaccharides as well as exploring their potential application in cosmetic and functional food products. The findings here exhibited that red seaweed polysaccharides and their degradation products were potential ingredients for cosmeceutical industries.

100 Deals associated with Chlorohexide/Lidocaine

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Indication	Highest Phase	Country/Location	Organization	Date
Pharyngitis	Phase 3	CH	A. Vogel AG	01 Feb 2006

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03095521 (CTgov)	Phase 3	Pharyngitis	228	Angal (ANGAL)	flrltajthj(caeedveyim) = twbhvpcbvx wwchfryjjl (mrirhlzaga, ssendapwpw - misppegkvr) View more	-	22 Mar 2019
				ANTIANGIN (ANTIANGIN)	flrltajthj(caeedveyim) = wpjovjlxfv wwchfryjjl (mrirhlzaga, qrdtxlmzuz - pwupdmixcn) View more

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