Delving into the Latest Updates on Absorbed diphtheria tetanus pertussis and r-Hepatitis B combined vaccine(Wuhan Institute of Biological Products Co., Ltd.) with Synapse

Overview

Basic Info

Drug Type

Combination vaccine, Prophylactic vaccine, Toxoid vaccine

+ [1]

Synonyms

Wu Sheng Yi Tai, Yi Tai, 武生益泰

Target-

Mechanism

Immunostimulants

Therapeutic Areas

Infectious DiseasesRespiratory DiseasesOther Diseases

Active Indication

DiphtheriaTetanusWhooping Cough

Inactive Indication-

Originator Organization

Wuhan Institute of Biological Products Co., Ltd.

Active Organization

Wuhan Institute of Biological Products Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (04 Sep 2006),

DiphtheriaTetanusWhooping Cough

Regulation-

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Yi du (Medicine Reading)was a primer of traditional Chinese medicine. The original author was Wang Ji of the Ming Dynasty, and the book was block-printed and published, after the supplement made by Cheng Yingmao of the Qing Dynasty during the reign of Kangxi Emperor of the Qing Dynasty. The editions of the book preserved in Nanjing Library and China Institute for History of Medicine and Medical Literature of China Academy of Chinese Medical Sciences was the original version in the reign of Kangxi Emperor. The edition in Shanghai University of Traditional Chinese Medicine was the amended version of original version in the reign of Kangxi Emperor. The version of Edo Period in the Cabinet Library of National Archives of Japan was the reprinted edition of the amended version of original version in the reign of Kangxi Emperor. The transcript of Mr. Wang Shishan's Medicine Reading of the Qing Dynasty in Nanjing Library and Suzhou Library was the hand-copied version of the original one, with 75 syndromes, including external contraction, internal injuries, woman miscellaneous diseases etc. and all sorts of prescriptions. Cheng Yingmao added his preface, 14 syndromes of children diseases and prescription verse, supplemented general notices, properties of materia medica, pulse manifestations, and revised some texts of pathogenesis to form the 7 volumes. The former 5 volumes of Yi du were in 4-character verses, the 6(th)~7(th) volumes were in 7-character verses, and the pill prescriptions were in prose, which made more convenient for beginners to read, remember, and for recitation.

01 Jun 2015·Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

[Study on the antibacterial activity of four kinds of nano-hydroxyapatite composites against Enterococcus faecalis].

Article

Author: Wu, Hongkun ; Zhou, Rongjing ; Liu, Yi

OBJECTIVEThis study aims to compare and determine a kind of nano-hydroxyapatite composite material with good antibacterial efficacy on Enterococcusfaecalis (E. faecalis) in vitro.METHODSWe investigated the antimicrobial activity of four kinds of nano-hydroxyapatite composites, namely, silver/hydroxyapatite composite nanoparticles (Ag/nHA), yttrium/hydroxyapatite composite nanoparticles (Yi/nHA), cerium/hydroxyapatite composite nanoparticles (Ce/nHA), and hydroxyapatite nanoparticles (nHA), against E. faecalis in vitro using the agar diffusion and broth dilution method by measuring the growth inhibition zone and the minimum inhibitory concentration (MIC), respectively.RESULTSThe agar diffusion test results showed that Ag/nHA displayed an obvious growth inhibition zone, whereas Yi/nHA, Ce/nHA, and nHA showed no influence on E. faecalis. The MIC value of Ag/nHA was 1.0 g.L-1, and the three other materials had no effect on E.faecalis even at the high concentration of 32.0 g.L-1.CONCLUSIONAg/nHA display a potential antimicrobial efficacy to planktonic E.faecalis. Whereas, the three other kinds of nano-hydroxyapatite composites (Yi/nHA, Ce/nHA, nHA) show no influence.

01 Mar 2014·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Mechanisms of yanshu injection for overcoming multidrug resistance in breast carcinoma MCF-7 cells: an experimental research].

Article

Author: Chen, Yang ; He, Qi-Yang ; Li, Hai-Yan

OBJECTIVETo investigate the mechanism of Yanshu Injection (YI) for overcoming multidrug resistance in breast carcinoma MCF-7 cells.METHODSHuman breast carcinoma MCF-7 cells and doxorubicin-resistant MCF-7/DOX cells were treated with YI. Its inhibition on the cell proliferation was detected by MTT assay. The fluorescence intensity of doxorubicin was detected by flow cytometry. The expression of apoptosis related protein and P-glycoprotein were examined by immunoblotting after treated by YI.RESULTSThe inhibitory action of YI on MCF-7/DOX cells was similar to that of MCF-7 cells, indicating no cross resistance (P > 0.05). 1/16 YI could obviously induce the apoptosis of MCF-7 cells and DOX cells. 1/256 YI +5 nmol/L doxorubicin and 1/128 YI +5 nmol/L doxorubicin could reduce the survival rate of MCF-7/ DOX resistant cells from 86.8% to 74.6% (P < 0.05) and 71.6% (P < 0.01) respectively, showing obvious synergistic effect. Besides, the accumulation of doxorubicin was increased after treated by YI in the MCF-7/ DOX cells. Results of immunoblotting indicated that reduction of P-glycoprotein expression was detected in MCF-7/DOX cells after exposure to YI.CONCLUSIONYI could overcome the multidrug resistance in breast carcinoma MCF-7 cells possibly through reducing the expression of P-glycoprotein.

100 Deals associated with Absorbed diphtheria tetanus pertussis and r-Hepatitis B combined vaccine(Wuhan Institute of Biological Products Co., Ltd.)

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	J07CA05	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Diphtheria	CN	Wuhan Institute of Biological Products Co., Ltd.	04 Sep 2006
Tetanus	CN	Wuhan Institute of Biological Products Co., Ltd.	04 Sep 2006
Whooping Cough	CN	Wuhan Institute of Biological Products Co., Ltd.	04 Sep 2006