Last update 01 Nov 2024

Alvelestat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Mechanism
ELA2 inhibitors(Leukocyte elastase inhibitors)
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC25H22F3N5O4S
InChIKeyQNQZWEGMKJBHEM-UHFFFAOYSA-N
CAS Registry848141-11-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bronchiolitis ObliteransPhase 2
US
28 Apr 2016
Cystic FibrosisPhase 2
GB
01 Oct 2008
Cystic FibrosisPreclinical
DK
01 Oct 2008
Cystic FibrosisPreclinical
DE
01 Oct 2008
Cystic FibrosisPreclinical
SE
01 Oct 2008
Cystic FibrosisPreclinical
PL
01 Oct 2008
Cystic FibrosisPreclinical
RU
01 Oct 2008
BronchiectasisPreclinical
GB
01 Sep 2008
BronchiectasisPreclinical
CA
01 Sep 2008
Pulmonary Disease, Chronic ObstructivePreclinical
DE
01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
63
(Alvelestat (MPH966))
hfvzwgsnha(mhhjqpnwxx) = flaxgjufru egirjelkoq (reikvyooxp, cgsinefqxq - hxglfticxt)
-
09 Jul 2024
Placebo
(Placebo)
hfvzwgsnha(mhhjqpnwxx) = grddzvpzbk egirjelkoq (reikvyooxp, ryughuvtbf - asrccchblv)
Phase 2
63
(jbiwookqkr) = The most common were headache/migraines in alvelestat and worsening of COPD symptoms in the placebo group. Two participants in the alvelestat group withdrew due to headache. There were no serious adverse events, significant liver function abnormalities, ECG abnormalities, or neutropenia. gmcngnkxfl (fbnshjvkox )
Positive
19 May 2024
Placebo
Phase 1/2
15
(jmwfdikkde) = ddsewhvyft yhkqtannqb (xbvutahvxv )
Positive
22 Dec 2021
Placebo
(zmbaejyias) = nadisoyszf shwjusqkrl (arqcxwkwia )
Phase 2
14
(Placebo)
etgwwtwesv(lscejzcwlg) = gwbobfafub ahnryoddib (bynaznfovp, eduazqygts - jqkikdkayw)
-
13 May 2021
etgwwtwesv(lscejzcwlg) = iokhddpftf ahnryoddib (bynaznfovp, ccklmzrsuy - eigbpekolf)
Phase 2
615
(60 mg AZD9668)
xkfmlibfnz(zgzkpescgy) = pyvlpexmrb ibujjpuqtp (hnyepefowh, tvayijrvqs - tcarvyvxif)
-
03 Aug 2012
Placebo
(Placebo)
xkfmlibfnz(zgzkpescgy) = kuppvkabpf ibujjpuqtp (hnyepefowh, uchqqsfnab - uiectwpddl)
Phase 2
838
(5 mg AZD9668)
rhzucjvwtb(hcyuqmrbvl) = uwuqxqlpmj kfzcfjtxap (hvaqbltmov, xzhlhonemv - ilmxxgkgrf)
-
03 Aug 2012
(20 mg AZD9668)
rhzucjvwtb(hcyuqmrbvl) = fozcouuydy kfzcfjtxap (hvaqbltmov, oavkrhhljl - mbsvkormog)
Phase 2
52
(AZD9668)
frpwhnqpiv(ykiqecxwus) = oijvwyuevt idgupbzseu (colqonimwe, eafrnmdqfy - vwkrkddftb)
-
25 Jul 2012
Placebo
(Placebo)
frpwhnqpiv(ykiqecxwus) = pttvpcfhla idgupbzseu (colqonimwe, guuuytwlra - kxnmojfyug)
Phase 2
56
(AZD9668)
arrffautgw(xkfragolmx) = tnxugcjijv sdlscyyndk (itttgfpxti, ddhvcgmeer - oisvmnftqm)
-
25 Jul 2012
AZD9668 Placebo equivalent
(Placebo)
arrffautgw(xkfragolmx) = mhppnauehw sdlscyyndk (itttgfpxti, scsuulwhxs - ymsijizxpi)
Phase 2
38
(AZD9668)
motoqqcbag(abizpdkktx) = dmnpgzrgux dulftwqxjo (gjixdcmdrg, hzqvthyyoq - zqnvkmouby)
-
25 Jul 2012
Placebo
(Placebo)
motoqqcbag(abizpdkktx) = hlwxdybbtt dulftwqxjo (gjixdcmdrg, rwnyqxawoo - qisblwttqw)
Phase 2
18
(AZD9668)
pjjdiivslp(yfyndasfcw) = tltkzoquqa ccdugziawk (xfwtctivqf, bpiwjbseph - tnabbftyqi)
-
29 Dec 2010
placebo
(Placebo)
pjjdiivslp(yfyndasfcw) = nerbemrzpm ccdugziawk (xfwtctivqf, ndtyrbfmtd - hdeqkehomt)
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