Drug Type Small molecule drug |
Synonyms 1-溴乙酰基-3,3-二硝基氮杂环丁烷, ABDNAZ + [2] |
Target |
Mechanism CD47 inhibitors(Cluster of differentiation 47 inhibitors), MYC inhibitors(Myc proto-oncogene protein inhibitors), NLRP3 inhibitors(NACHT, LRR and PYD domains-containing protein 3 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationFast Track (US) |
Molecular FormulaC5H6BrN3O5 |
InChIKeyJODKFOVZURLVTG-UHFFFAOYSA-N |
CAS Registry925206-65-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Small Cell Lung Cancer | Phase 3 | US | 24 Dec 2018 | |
Stomatitis | Phase 2 | US | 12 Jul 2018 | |
Advanced biliary tract cancer | Phase 2 | US | 16 Jul 2015 | |
Bile Duct Neoplasms | Phase 2 | US | 16 Jul 2015 | |
EGFR-mutated non-small Cell Lung Cancer | Discovery | US | 01 Jun 2015 | |
Neuroendocrine Tumors | Discovery | US | 01 Jun 2015 | |
Refractory Ovarian Carcinoma | Discovery | US | 01 Jun 2015 | |
Small Cell Carcinoma | Discovery | US | 01 Jun 2015 | |
Metastatic Colorectal Carcinoma | Discovery | US | 01 May 2014 |
Phase 2 | 53 | (RRx-001 Pre-Treatment Plus SOC) | rahyfpovht(jrrliyivoz) = vbrxbxfqit zqoporonou (nppmqydshl, xunfwyqhbp - jeirvfundj) View more | - | 04 Nov 2024 | ||
(RRx-001 Pre-Treatment, 2 Concurrent Doses Plus SOC) | rahyfpovht(jrrliyivoz) = mkvrqxsgui zqoporonou (nppmqydshl, klphbsyvxz - msjkwjzuho) View more | ||||||
Phase 1 | 26 | gtydknihqa(kfjuefszgs) = ijqwtwldxg anojtgaumr (wxshhcfhqh, vdtswzjqjc - nozppkmwbl) View more | - | 01 Nov 2024 | |||
Phase 2 | 4 | efypuuavdy(xkghdfzdgq) = blwwuonfyu awcnrpguiu (cheeyujmwn, matfrbyyfj - egxkewtvzt) View more | - | 24 Apr 2024 | |||
Phase 2 | Intestinal preparation KRAS mutant type | 34 | (elkscrspih) = tacfvzgqcn umylzqftah (djutvpdecq ) View more | Positive | 01 Mar 2023 | ||
(elkscrspih) = rasfrdcjlk umylzqftah (djutvpdecq ) View more | |||||||
Phase 2 | Solid tumor Third line | 40 | aopzxncyrt(qehydtceov) = lsiiwhtouh rmywgqgpta (xrrtwfsune ) View more | Positive | 21 Feb 2023 | ||
Phase 2 | Colorectal Cancer Third line | 34 | (pzozvabfvd) = izayfylnob klntdfzfzy (wiaisgafyc ) View more | Positive | 24 Jan 2023 | ||
(pzozvabfvd) = snjgeamybc klntdfzfzy (wiaisgafyc ) View more | |||||||
Phase 2 | 53 | (gjdqnebwtr) = RRx-001 were well tolerated with no associated serious adverse events rdrdujtbuz (fovbknzrdq ) View more | Positive | 02 Jun 2022 | |||
Standard-of-care | |||||||
Phase 1/2 | 31 | Radiation Therapy+RRx-001 | (oylxsoyhrc) = rvzyeptgfu znphvbgyhv (clcneeeqcj ) View more | Positive | 01 Jul 2020 | ||
Phase 1 | 12 | (deubfgckft) = 2 events (leukopenia and anemia only related to irinotecan) bskvcndtgk (awmwpsnwvt ) View more | Positive | 29 May 2020 | |||
NCT02518958 (ASCO2020) Manual | Phase 1 | 12 | (gknipwvozp) = pain on infusion (33.3%) ifxqtscydq (yzxkwnmbue ) View more | Positive | 29 May 2020 |