Last update 21 Nov 2024

Nibrozetone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-溴乙酰基-3,3-二硝基氮杂环丁烷, ABDNAZ
+ [2]
Mechanism
CD47 inhibitors(Cluster of differentiation 47 inhibitors), MYC inhibitors(Myc proto-oncogene protein inhibitors), NLRP3 inhibitors(NACHT, LRR and PYD domains-containing protein 3 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US)
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Structure

Molecular FormulaC5H6BrN3O5
InChIKeyJODKFOVZURLVTG-UHFFFAOYSA-N
CAS Registry925206-65-1

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Small Cell Lung CancerPhase 3
US
24 Dec 2018
StomatitisPhase 2
US
12 Jul 2018
Advanced biliary tract cancerPhase 2
US
16 Jul 2015
Bile Duct NeoplasmsPhase 2
US
16 Jul 2015
EGFR-mutated non-small Cell Lung CancerDiscovery
US
01 Jun 2015
Neuroendocrine TumorsDiscovery
US
01 Jun 2015
Refractory Ovarian CarcinomaDiscovery
US
01 Jun 2015
Small Cell CarcinomaDiscovery
US
01 Jun 2015
Metastatic Colorectal CarcinomaDiscovery
US
01 May 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
53
(RRx-001 Pre-Treatment Plus SOC)
rahyfpovht(jrrliyivoz) = vbrxbxfqit zqoporonou (nppmqydshl, xunfwyqhbp - jeirvfundj)
-
04 Nov 2024
(RRx-001 Pre-Treatment, 2 Concurrent Doses Plus SOC)
rahyfpovht(jrrliyivoz) = mkvrqxsgui zqoporonou (nppmqydshl, klphbsyvxz - msjkwjzuho)
Phase 1
26
gtydknihqa(kfjuefszgs) = ijqwtwldxg anojtgaumr (wxshhcfhqh, vdtswzjqjc - nozppkmwbl)
-
01 Nov 2024
Phase 2
4
efypuuavdy(xkghdfzdgq) = blwwuonfyu awcnrpguiu (cheeyujmwn, matfrbyyfj - egxkewtvzt)
-
24 Apr 2024
Phase 2
Intestinal preparation
KRAS mutant type
34
(elkscrspih) = tacfvzgqcn umylzqftah (djutvpdecq )
Positive
01 Mar 2023
(elkscrspih) = rasfrdcjlk umylzqftah (djutvpdecq )
Phase 2
Solid tumor
Third line
40
aopzxncyrt(qehydtceov) = lsiiwhtouh rmywgqgpta (xrrtwfsune )
Positive
21 Feb 2023
Phase 2
34
(pzozvabfvd) = izayfylnob klntdfzfzy (wiaisgafyc )
Positive
24 Jan 2023
(pzozvabfvd) = snjgeamybc klntdfzfzy (wiaisgafyc )
Phase 2
53
(gjdqnebwtr) = RRx-001 were well tolerated with no associated serious adverse events rdrdujtbuz (fovbknzrdq )
Positive
02 Jun 2022
Standard-of-care
Phase 1/2
31
Radiation Therapy+RRx-001
(oylxsoyhrc) = rvzyeptgfu znphvbgyhv (clcneeeqcj )
Positive
01 Jul 2020
Phase 1
12
(deubfgckft) = 2 events (leukopenia and anemia only related to irinotecan) bskvcndtgk (awmwpsnwvt )
Positive
29 May 2020
Phase 1
12
(gknipwvozp) = pain on infusion (33.3%) ifxqtscydq (yzxkwnmbue )
Positive
29 May 2020
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Approval

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Regulation

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