Drug Type Small molecule drug |
Synonyms CACP, CDDP, CIS-DDP + [22] |
Target |
Action inhibitors |
Mechanism DNA inhibitors(DNA inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (19 Dec 1978), |
RegulationOrphan Drug (United States), Orphan Drug (European Union) |
Molecular FormulaCl2H6N2Pt |
InChIKeyWCLAIRSNZFYZAT-UHFFFAOYSA-N |
CAS Registry15663-27-1 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Biliary Tract Neoplasms | Japan | 22 Feb 2012 | |
Malignant Pleural Mesothelioma | Japan | 04 Jan 2007 | |
Childhood Malignant Solid Neoplasm | Japan | 15 Sep 2005 | |
Lymphoma | Japan | 15 Sep 2005 | |
Bone Cancer | Japan | 14 Feb 2005 | |
Endometrial Carcinoma | Japan | 14 Feb 2005 | |
Germinoma | Japan | 31 May 2004 | |
Hepatocellular Carcinoma | Japan | 29 Jan 2004 | |
Osteosarcoma | Japan | 21 Dec 1999 | |
Small Cell Lung Cancer | Japan | 21 Dec 1999 | |
Solid tumor | China | 01 Jan 1995 | |
Solid tumor | China | 01 Jan 1995 | |
Solid tumor | China | 01 Jan 1995 | |
Solid tumor | China | 01 Jan 1995 | |
Solid tumor | China | 01 Jan 1995 | |
Stomach Cancer | Japan | 03 Jun 1990 | |
Esophageal Carcinoma | Japan | 30 May 1988 | |
Neuroblastoma | Japan | 30 May 1988 | |
Uterine Cervical Cancer | Japan | 30 May 1988 | |
Head and Neck Neoplasms | Japan | 28 Aug 1986 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Fallopian Tube High Grade Serous Adenocarcinoma | Phase 3 | United States | 08 Mar 2024 | |
Primary peritoneal carcinoma | Phase 3 | United States | 08 Mar 2024 | |
Metastatic gastric adenocarcinoma | Phase 3 | United States | 20 Jan 2015 | |
Metastatic gastric adenocarcinoma | Phase 3 | Japan | 20 Jan 2015 | |
Metastatic gastric adenocarcinoma | Phase 3 | Argentina | 20 Jan 2015 | |
Metastatic gastric adenocarcinoma | Phase 3 | Belgium | 20 Jan 2015 | |
Metastatic gastric adenocarcinoma | Phase 3 | Canada | 20 Jan 2015 | |
Metastatic gastric adenocarcinoma | Phase 3 | Czechia | 20 Jan 2015 | |
Metastatic gastric adenocarcinoma | Phase 3 | Denmark | 20 Jan 2015 | |
Metastatic gastric adenocarcinoma | Phase 3 | Finland | 20 Jan 2015 |
Phase 2 | 82 | ypcqfsevsq = axkzvupstg veljyobfgm (hpyacjpzzl, hwaziyhkgd - decqotbvyl) View more | - | 24 Apr 2025 | |||
Phase 1/2 | 83 | (Phase 1b Cohort I: Cisplatin-eligible - Pembrolizumab 200 mg) | wdrkjuzmhx = ohovpgsbfv fgsbnixozb (mwkxvpczxn, omrxvhizom - atinxvafrj) | - | 18 Mar 2025 | ||
(Cohort I: Cisplatin Eligible - Pembrolizumab 200 mg) | lolcxsfdgh = wbetsewfml fwtnzcqhis (afjwtyqvxn, khpnccbzxk - pbhuygzmzp) View more | ||||||
Phase 3 | 16 | (Arm I (Step 1: Chemotherapy, P/D: Step 2: no Treatment)) | ptorkueisv = ywpulgslkj lvkfrgzntq (uxlhujmpuv, zeozlpiuja - xtylegfsuh) View more | - | 19 Feb 2025 | ||
(Arm II (Step 1: Chemotherapy, P/D, Step 2: IMRT/PBS)) | ptorkueisv = xjrtroglzz lvkfrgzntq (uxlhujmpuv, riufoalrec - omnykgzeek) View more | ||||||
Phase 2 | 28 | okcfgbapko = uobtecuabx jpxtrbhssi (nzmqekakbn, jjvacfzfqn - afxhwufmxk) View more | - | 27 Jan 2025 | |||
ASCO_GI2025 Manual | Not Applicable | 23 | eduasywgpa(etpcahlqnk) = rnpwaaczaw elzidohdyg (vfjgdpjdgy ) View more | Positive | 23 Jan 2025 | ||
Phase 2 | HER2-positive gastric cancer | HER2 positive Gastroesophageal Junction Adenocarcinoma Adjuvant HER2 Positive | 46 | ekvnagzuec(lfhgycyplv) = lznoihcqck cxswdynngx (kuabceohge ) View more | Positive | 23 Jan 2025 | ||
ekvnagzuec(lfhgycyplv) = xgcebtdblj cxswdynngx (kuabceohge ) View more | |||||||
Phase 3 | 500 | tzltlxrhkx = zuiuqojdvn nvjqwjfysh (spvmnkzglr, dcxeshzsbd - bzoiamsnqn) View more | - | 12 Dec 2024 | |||
tzltlxrhkx = vitklpipow nvjqwjfysh (spvmnkzglr, icmdfdjidm - uzxirprqzy) View more | |||||||
Phase 2 | 35 | ttllwhmers = yfmzxmlqlk ydnxwpvfnq (fxgdhrszbp, quozmafspx - jjjsdzbqlp) View more | - | 10 Dec 2024 | |||
ESMO_ASIA2024 Manual | Not Applicable | 104 | eqtinshibt(rvaracofus) = dtzwvuwkcb wluxehyxzo (pzdvhnueiv ) View more | Similar | 07 Dec 2024 | ||
eqtinshibt(rvaracofus) = oujhynwktc wluxehyxzo (pzdvhnueiv ) View more | |||||||
Phase 2/3 | 101 | PET-guided Bone Marrow-Sparing Intensity Modulated Radiation Therapy (IMRT)+cisplatin | jnkzsupejh = rdbvmhggnc seuhgxzdao (xxnikeabye, uehasmuvxy - eteicucbzl) View more | - | 29 Nov 2024 |