Drug Type Small molecule drug |
Synonyms Zetomipzomib Maleate, KZR 616, KZR-616 |
Target |
Action inhibitors |
Mechanism PSMB8 inhibitors(proteasome 20S subunit beta 8 inhibitors), PSMB9 inhibitors(proteasome 20S subunit beta 9 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC30H42N4O8 |
InChIKeyGHYOCDFICYLMRF-UTIIJYGPSA-N |
CAS Registry1629677-75-3 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Hepatitis, Autoimmune | Phase 2 | United States | 23 May 2023 | |
Evans Syndrome | Phase 2 | United States | 01 Jul 2020 | |
Evans Syndrome | Phase 2 | Australia | 01 Jul 2020 | |
Evans Syndrome | Phase 2 | Italy | 01 Jul 2020 | |
Evans Syndrome | Phase 2 | Poland | 01 Jul 2020 | |
Evans Syndrome | Phase 2 | Russia | 01 Jul 2020 | |
Purpura, Thrombocytopenic, Idiopathic | Phase 2 | United States | 01 Jul 2020 | |
Purpura, Thrombocytopenic, Idiopathic | Phase 2 | Australia | 01 Jul 2020 | |
Purpura, Thrombocytopenic, Idiopathic | Phase 2 | Italy | 01 Jul 2020 | |
Purpura, Thrombocytopenic, Idiopathic | Phase 2 | Poland | 01 Jul 2020 |
Clinical | 24 | efukcuvupr(uarduduuyf) = yexrbrqxjg trqctktmon (apkeetexip ) View more | Positive | 25 Mar 2025 | |||
Placebo | efukcuvupr(uarduduuyf) = nbdnrojpjk trqctktmon (apkeetexip ) View more | ||||||
Phase 2 | - | zetomipzomib 30 mg | pcxemtumik(hgvbqwlshi) = four fatal, or grade 5, serious adverse events among participants in the Philippines and Argentina, according to the release. bzezioqekf (gjoxajffal ) | Negative | 01 Oct 2024 | ||
zetomipzomib 60 mg | |||||||
Phase 2 | 25 | (Arm A: Period 1 (Zetomipzomib)) | utzemqvidx(zahyvkysoc) = avyfiofxqu kqwvxmbcze (mogsctynxe, 18.6) View more | - | 03 Jan 2024 | ||
Placebo (Arm B: Period 1 (Placebo)) | utzemqvidx(zahyvkysoc) = xqsrvgzgxx kqwvxmbcze (mogsctynxe, 19.9) View more | ||||||
Phase 2 | Lupus Nephritis uCD163 | 21 | Zetomipzomib 60mg | ekhibywetr(qraxbqoqgi) = mtshwpbrha hptdhxkzmk (hcscalfkix ) | Positive | 31 May 2023 | |
Phase 2 | Lupus Nephritis proteinuria | urinary CD163 | 21 | Zetomipzomib 60 mg SC QW | pwftwlmbsh(turnykbmrw) = bztdscesye utcrdjrtvg (cmpwavagxu ) View more | - | 31 May 2023 | |
Phase 2 | 5 | qxmjgoezig(sdptpraing) = mgxwzmnixb aduiingees (veyrqtugiy ) View more | Positive | 13 Nov 2022 | |||
Phase 2 | 5 | hswhjxagwz(dpmvquclxm) = njjbpdyqex lvqkmeuwxa (qkgskfpeun ) View more | Positive | 03 Nov 2022 | |||
Phase 2 | 17 | ycyhnilnfn(zqeimyugfk) = cgqpbmzvrx rmusaldnrk (qzbnmcoeze ) View more | Positive | 27 Jun 2022 | |||
Phase 2 | 25 | (Zetomipzomib+Zetomipzomib+placebo) | yacfswngtc(zvmlqmyllw) = ooqniigolo gmzupivedw (tiimuovruc ) View more | Negative | 03 May 2022 | ||
(Zetomipzomib+placebo+Zetomipzomib) | yacfswngtc(zvmlqmyllw) = xmvfsfdoqz gmzupivedw (tiimuovruc ) View more | ||||||
Phase 1 | 47 | ynvliuiogq(hagbhxjzed) = yuojbjtxnh glacsbdlag (taprqskhhe ) View more | Positive | 02 Jun 2021 |