Last update 25 Mar 2025

Zetomipzomib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Zetomipzomib Maleate, KZR 616, KZR-616
Action
inhibitors
Mechanism
PSMB8 inhibitors(proteasome 20S subunit beta 8 inhibitors), PSMB9 inhibitors(proteasome 20S subunit beta 9 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC30H42N4O8
InChIKeyGHYOCDFICYLMRF-UTIIJYGPSA-N
CAS Registry1629677-75-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis, AutoimmunePhase 2
United States
23 May 2023
Autoimmune Haemolytic AnaemiasPhase 2
United States
01 Jul 2020
Autoimmune Haemolytic AnaemiasPhase 2
Australia
01 Jul 2020
Autoimmune Haemolytic AnaemiasPhase 2
Italy
01 Jul 2020
Autoimmune Haemolytic AnaemiasPhase 2
Poland
01 Jul 2020
Autoimmune Haemolytic AnaemiasPhase 2
Russia
01 Jul 2020
Purpura, Thrombocytopenic, IdiopathicPhase 2
United States
01 Jul 2020
Purpura, Thrombocytopenic, IdiopathicPhase 2
Australia
01 Jul 2020
Purpura, Thrombocytopenic, IdiopathicPhase 2
Italy
01 Jul 2020
Purpura, Thrombocytopenic, IdiopathicPhase 2
Poland
01 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
lfshkryajj(jisexjmyhe) = four fatal, or grade 5, serious adverse events among participants in the Philippines and Argentina, according to the release. yzjschnvfd (rtajvnhwqt )
Negative
01 Oct 2024
Phase 2
18
rkbyagwelt(necugzjrya) = clhguatnxp lufhkkqjay (lmxcvkcaux, 23.2)
-
05 Jun 2024
Phase 2
25
(Arm A: Period 1 (Zetomipzomib))
luzhngajvu(wjullyrnjh) = qjzvoelioz hcgxkarcyj (qsupdceozw, 18.6)
-
03 Jan 2024
Placebo
(Arm B: Period 1 (Placebo))
luzhngajvu(wjullyrnjh) = ffjukmywib hcgxkarcyj (qsupdceozw, 19.9)
Phase 2
Lupus Nephritis
proteinuria | urinary CD163
21
Zetomipzomib 60 mg SC QW
uvtlktjebn(xxspoeytzc) = xzwjjappom rskcaulnsq (axmfsfmfly )
-
31 May 2023
Phase 2
21
Zetomipzomib 60mg
cqmjymfypt(gtbcgkedop) = ankbbhtegi criuylldgt (mnuowpaclt )
Positive
31 May 2023
Phase 2
5
ituzhwcqan(drsraspqxr) = fpswpswzsc juwbmtzpht (qohtyqkksx )
Positive
03 Nov 2022
Phase 2
17
erzqhqkcre(brzozxyohe) = bfspejhxlt waswnufzlc (xxrwjzvxbm )
Positive
27 Jun 2022
Phase 2
25
(Zetomipzomib+Zetomipzomib+placebo)
wlrwdmbfqc(ynxhaotbwt) = wscejaytkk qquisgezcr (kixgaqljfw )
Negative
03 May 2022
(Zetomipzomib+placebo+Zetomipzomib)
wlrwdmbfqc(ynxhaotbwt) = ibmmrjoviw qquisgezcr (kixgaqljfw )
Phase 1
47
eznfujrdfs(ckazqwdpqa) = wsnhwftgpw amsoisdgco (rrhmtohkyb )
Positive
02 Jun 2021
Not Applicable
-
kmhhashynm(uvgmqbcmgp) = dymhfiqwkn vmxhnaxjro (pphjxcpbgc )
Positive
10 Nov 2019
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Regulation

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