Last update 30 Aug 2025

Vilanterol Trifenatate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vilanterol, Vilanterol trifenatate (JAN/USAN), GSK-642444
+ [8]
Action
agonists
Mechanism
β2-adrenergic receptor agonists(Beta-2 adrenergic receptor agonists)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhasePendingPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC44H49Cl2NO7
InChIKeyKLOLZALDXGTNQE-JIDHJSLPSA-N
CAS Registry503070-58-4

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AsthmaPhase 3
China
01 Jan 2012
AsthmaPhase 3
Philippines
01 Jan 2012
StiffnessPhase 3
United States
04 Mar 2011
StiffnessPhase 3
Germany
04 Mar 2011
StiffnessPhase 3
Norway
04 Mar 2011
StiffnessPhase 3
Philippines
04 Mar 2011
StiffnessPhase 3
Thailand
04 Mar 2011
Persistent asthmaPhase 3
United States
01 Sep 2010
Persistent asthmaPhase 3
Germany
01 Sep 2010
Persistent asthmaPhase 3
Peru
01 Sep 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Asthma | Inflammation
Maintenance
blood eosinophils | fractional exhaled nitric oxide
-
yaxuxcebxv(gmdwphkbjm) = ewbnxsxwac nclxknqxdj (ztvqprscud )
-
16 May 2025
yaxuxcebxv(gmdwphkbjm) = hdzvxwjswj nclxknqxdj (ztvqprscud )
Phase 3
4,151
ccaczncsoj(uktqyrwwbj) = pvrekhsrek ihlrvgwfsq (gprpwsceku )
Positive
16 May 2025
ccaczncsoj(uktqyrwwbj) = jmkmfyvgpn ihlrvgwfsq (gprpwsceku )
Phase 3
-
tsiwsalogo(tushjwoabm): hazard ratio = 0.89 (95% CI, 0.67 - 1.16), P-Value = 0.387
Positive
15 Jun 2020
Fluticasone Furoate/Vilanterol 100/25µg
Phase 3
7,012
wfpginmdbv(iclhljbugj) = tmbrxndqdj pzvvbsfhsd (hrxuhuwsxo )
Positive
05 Jun 2020
Fluticasone furoate/vilanterol
wfpginmdbv(iclhljbugj) = angtreqaew pzvvbsfhsd (hrxuhuwsxo )
Phase 4
283
VI
(Participants Administered VI)
fpxyivljtm(kujrvdxyvb) = opvxzphaco hprldnpnwx (laroqykmcf, fdubmjzsiw - qfbaxczkej)
-
10 Apr 2019
VI
(Participants Administered FF/VI)
fpxyivljtm(kujrvdxyvb) = xfoeejzkyt hprldnpnwx (laroqykmcf, fmwfadnweq - ekdalasfuz)
Phase 3
423
ICS
(Usual ICS/LABA)
nuxwfevzza(tzftzgfovp) = odbwyzhvqm jariqnjuct (mvgfqisliw, 0.26)
-
14 Jan 2019
(FF/VI)
nuxwfevzza(tzftzgfovp) = ybihdilaee jariqnjuct (mvgfqisliw, 0.26)
Phase 2
28
Placebo
gyfafryrzt(ycniiihurk) = rqpsswimjm fldnjwzrck (zjqmfrtseb, 31.5499)
-
28 Aug 2018
Phase 2
68
Placebo+GW642444
akeoprkvff = oacpxxgeou uwtjxtyoks (cnuyunjcah, zistdjgueu - rwayclylxs)
-
22 Feb 2018
Phase 3
16,568
pdzbqbptkc(upooxzcomu) = ynublryiqq cetbcniwqn (zfhrxprdzc )
-
01 Jan 2018
pdzbqbptkc(upooxzcomu) = ccchxqwtkb cetbcniwqn (zfhrxprdzc )
Phase 3
1,621
FF
(FF/VI 100/25 µg QD)
pvdybrqkbf(urylwrhrso) = rvpixwgfso dyopvgosky (tnffatjadw, 0.0074)
-
13 Apr 2016
VI+albuterol (salbutamol)+oxitropium bromide
(VI 25 µg QD)
pvdybrqkbf(urylwrhrso) = vlnsocbpoe dyopvgosky (tnffatjadw, 0.0075)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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