Fish Oil Triglycerides

WEDNESDAY, Aug. 14, 2024 -- Fish oil seems to counteract genetic predisposition to high cholesterol, according to a study published online July 15 in the American Journal of Clinical Nutrition . Yitang Sun, Ph.D., from the Franklin College of Arts and Sciences at the University of Georgia in Athens, and colleagues examined whether fish oil supplementation modifies the association between genetically predicted and observed concentrations of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. The analysis included data from 441,985 participants in the U.K. Biobank. The researchers found that fish oil supplementation attenuates the associations between genetically predicted and observed circulating concentrations of total cholesterol, LDL cholesterol, and triglycerides while accentuating the corresponding association for HDL cholesterol. Findings were consistent across different polygenic score (PGS) calculation methods. Each standard deviation increment in PGS for triglycerides was associated with a 0.254 increase in the observed concentration of participants reporting fish oil usage. A stronger association was seen in nonusers (0.267). Similarly, fish oil significantly attenuates the association between genetically predicted and observed concentrations of triglycerides in participants of African ancestry. "Our study shows that considering lifestyles will improve genetic prediction," coauthor Kaixiong Ye, Ph.D., also from the Franklin College of Arts and Sciences, said in a statement. "Our findings also support that fish oil supplements may counteract the genetic predisposition to high cholesterol." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

THURSDAY, Aug. 8, 2024 -- People with a genetic predisposition for high cholesterol can lower their levels by taking fish oil supplements, a new study shows. The results indicate that lifestyle can be a powerful influence on artery-clogging cholesterol, even if a person’s genetics tends to make those levels higher, researchers said. “Recent advances in genetic studies have allowed us to predict someone’s genetic risk of high cholesterol,” said lead researcher Yitang Sun , a doctoral graduate from the University of Georgia’s Department of Genetics. “But the current prediction has room for improvement because it does not consider individual differences in lifestyles, such as taking fish oil supplements,” Sun added in a university news release. About 1 in 4 Americans -- more than 86 million -- have high cholesterol, the researchers said in background notes. Millions more are at risk for high cholesterol because of their genetics, the researchers added. For the study, researchers used genetic data on more than 441,000 British residents to calculate each person’s genetic likelihood of high levels of cholesterol. The study participants are taking part in a large-scale research project called the UK Biobank. As part of that project, the people also reported in a questionnaire whether they take fish oil supplements and provided a blood sample for a cholesterol check. Results show that participants taking fish oil had lower blood cholesterol levels than would be expected, given their genetics. That was especially true of their total cholesterol, “bad” LDL cholesterol, and triglyceride levels, researchers said. The research team also found that fish oil supplements can boost levels of “good” HDL cholesterol. The new study was published recently in the American Journal of Clinical Nutrition . “Our study shows that considering lifestyles will improve genetic prediction,” added senior researcher Kaixiong Ye , an assistant professor of genetics at the University of Georgia. “Our findings also support that fish oil supplements may counteract the genetic predisposition to high cholesterol.” Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.