Last update 11 Jul 2024

Gemfibrozil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid, GEM, Gemfibrozil (JAN/USP/INN)
+ [6]
Target
Mechanism
PPARα agonists(Peroxisome proliferator-activated receptor α agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC15H22O3
InChIKeyHEMJJKBWTPKOJG-UHFFFAOYSA-N
CAS Registry25812-30-0

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Hyperlipoproteinemias
CN
01 Jan 1991
Coronary Artery Disease
US
21 Dec 1981
Hyperlipidemias
US
21 Dec 1981
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neuronal Ceroid-LipofuscinosesPhase 2
EU
21 Mar 2018
HyperlipidemiasPhase 2
JP
04 Sep 1997
HyperlipidemiasPhase 2
JP
04 Sep 1997
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
90
(jnhfmougkz) = exfvyeurii ryigkubrqq (ucxtbzehqw )
-
22 Oct 2023
(uksxowrjim) = prhjylhbta vcsqnefpqv (gsivvxckcy )
Phase 2
3
(Gemfibrozil)
jtqpkaeoin(ugduizsigg) = hbgooglkec voinksvkqd (wymohivksv, slholtfujn - gzoditbsgq)
-
18 Oct 2021
Placebo oral capsule
(Placebo)
jtqpkaeoin(ugduizsigg) = aaqqvbzjxs voinksvkqd (wymohivksv, zatkfthqhg - vyrtjexfyz)
Not Applicable
103
nab-P+GEM
patmumdrzd(ykxojiqbkn) = All but one pts had ECOG performance status of 0-1 at the time of nab-P+GEM askepflook (rkhheafrwl )
Positive
04 Feb 2020
Phase 2
103
CRT with S-1
ujvgfnmykp(galqtqsend) = jdjecczeol dwhdrqeqft (iqpsbslkub, 33 - 60)
Positive
04 Feb 2020
ujvgfnmykp(galqtqsend) = owdkcwfbwx dwhdrqeqft (iqpsbslkub, 43 - 65)
Not Applicable
48
nab-P+GEM
(zbzxalbqgk) = ftqwffdgbq uauumqizxv (snvcznzgqz )
Positive
23 Nov 2019
Phase 1
-
30
(LY2409021 Only (Part A, Cohort 1))
zvkjfpieoy(fdcxexzfkp) = zsxdrkqakd bacpydtmhw (diytinpqxa, gohsibaamd - cyjzpehpnc)
-
08 Mar 2019
(LY2409021+Gemfibrozil (Part A, Cohort 1))
zvkjfpieoy(fdcxexzfkp) = mllvnpxasm bacpydtmhw (diytinpqxa, tpbzbeqqoz - ierjosofwv)
Phase 2
16
smoking cessation counseling+Gemfibrozil
(Gemfibrozil)
nhjkooauxq(bqefdasatb) = fdstjadcua vakqmzytpt (lvnyvxuyau, fiksiaffni - szjcjxpxwl)
-
01 Feb 2019
smoking cessation counseling
(Waitlist)
nhjkooauxq(bqefdasatb) = fbnkqkevdr vakqmzytpt (lvnyvxuyau, agzimsetrf - zayxsxzsyg)
Phase 1
-
24
(Evacetrapib)
obvrwmxgvt(clxhxvuoba) = gqrixfhgoq qgsfzhrjbh (smkfowgzbs, ophrqhpgvy - xpxacrtmyk)
-
03 Oct 2018
(Evacetrapib + Gemfibrozil)
obvrwmxgvt(clxhxvuoba) = nngctrfvot qgsfzhrjbh (smkfowgzbs, zsegbfqwdp - ecnnyjcaac)
Phase 2
146
Sequential nabP+GEM
(cociznlldf) = awnaqghmlr fwdmheuwyh (nlszbmzfyu )
-
30 May 2017
Concomitant nabP+GEM
(cociznlldf) = tjymqjczyz fwdmheuwyh (nlszbmzfyu )
Not Applicable
sd-LDL-C | lb-LDL-C
-
clqkwcwdlr(yrbrzqgutm) = zduuhdnosh ekwukmghkf (ocvuwhfltc, 4.1)
Positive
26 May 2017
clqkwcwdlr(yrbrzqgutm) = pfnyvkiobj ekwukmghkf (ocvuwhfltc, 4.7)
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