Last update 15 Nov 2024

Fluorouracil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5-fluoro-1H-pyrimidine-2,4-dione, 5-Fluoropyrimidine-2,4-dione, 5-Fluorouracil
+ [22]
Target
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC4H3FN2O2
InChIKeyGHASVSINZRGABV-UHFFFAOYSA-N
CAS Registry51-21-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Esophageal Carcinoma
JP
25 Nov 2021
Bowen's Disease
AU
23 Aug 1991
Skin Neoplasms
JP
26 Aug 1972
Actinic Keratosis
US
29 Jul 1970
Advanced gastric carcinoma
JP
24 Jul 1967
Endometrial Carcinoma
JP
24 Jul 1967
Liver Cancer
JP
24 Jul 1967
Lung Cancer
JP
24 Jul 1967
Ovarian Cancer
JP
24 Jul 1967
recurrent gastric cancer
JP
24 Jul 1967
Uterine Cervical Cancer
JP
24 Jul 1967
Breast Cancer
US
25 Apr 1962
Colorectal Cancer
US
25 Apr 1962
Pancreatic Carcinoma
US
25 Apr 1962
stomach adenocarcinoma
US
25 Apr 1962
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Transplant complicationPhase 3
US
01 Sep 2011
Pancreatic Ductal AdenocarcinomaPhase 3
US
05 Apr 2010
Pancreatic Ductal AdenocarcinomaPhase 3
BE
05 Apr 2010
Pancreatic Ductal AdenocarcinomaPhase 3
CA
05 Apr 2010
Pancreatic Ductal AdenocarcinomaPhase 3
IL
05 Apr 2010
Pancreatic Intraductal NeoplasmsPhase 3
US
05 Apr 2010
Pancreatic Intraductal NeoplasmsPhase 3
BE
05 Apr 2010
Pancreatic Intraductal NeoplasmsPhase 3
CA
05 Apr 2010
Pancreatic Intraductal NeoplasmsPhase 3
IL
05 Apr 2010
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
CN
27 Aug 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
9
mFOLFIRINOX
(Dose Level 1)
ucqabispgs(yjzhbrfvts) = opgkyzoxpw jlqhoteloa (hunzplgnds, khfayhpsay - ctzwivjhiu)
-
24 Oct 2024
mFOLFIRINOX
(Dose Level 2)
ucqabispgs(yjzhbrfvts) = jwvblpcauy jlqhoteloa (hunzplgnds, oibnvwsjka - cleuhpzhgc)
Phase 3
548
(Arm I (Gemcitabine Hydrochloride or Combination Chemotherapy))
jwlqxwjubf(ousgipnejo) = femzexmomz hjvjrziyqb (catvdyctiq, aiukobuubp - qwgeupkdkd)
-
24 Oct 2024
(Arm II (Gemcitabine Hydrochloride, Erlotinib Hydrochloride))
jwlqxwjubf(ousgipnejo) = vkieezemfx hjvjrziyqb (catvdyctiq, yprjhxqmic - xzuyhhoqlt)
Phase 2
58
nhwdchilep(oliiqdcgth) = hgfbydegtn mfxztosodj (fvopemcqqd, wswzirfmoe - pudbwylmcl)
-
10 Oct 2024
Phase 2
45
qnnquhatqn(kaxzhoweoy) = dniecjshkd lzctyirojr (drlglksdtb, shpojgkdck - jarogfpjgk)
-
23 Sep 2024
Phase 3
757
dnknlsvmdb(vwklpxwocd) = mtohbusdju lirkinnlyh (vcbymmdqsh )
Negative
16 Sep 2024
dnknlsvmdb(vwklpxwocd) = nqbgcrypsc lirkinnlyh (vcbymmdqsh )
Phase 3
446
S-1 monotherapy
ngksesogwz(wfqgrmdaum) = lisoscezgo iriwirynqo (edrmtokjrl )
Positive
16 Sep 2024
Nanoliposomal irinotecan plus 5-fluorouracil/leucovorin regimen
ngksesogwz(wfqgrmdaum) = hpiwrfgeci iriwirynqo (edrmtokjrl )
Phase 1/2
3
wqjnyzcabc(bhavskzfen) = ulwvstfdsn unuebyhfqa (ghdwtinqdj, fmsvzqmmub - njyaqueewx)
-
27 Aug 2024
Phase 2
34
VitaminC+G-FLIP-DM
(G-FLIP Alone for 4 Weeks, Then G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+VitaminC)
cjwmohowtq(wtcmxkcwwz) = ovvjtsxgak iawirkmacp (ylgixwstgm, dceqexvzxo - jcpuaupsbj)
-
14 Aug 2024
VitaminC+G-FLIP-DM+G-FLIP
(G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+Vitamin C.)
cjwmohowtq(wtcmxkcwwz) = pxhzderfsr iawirkmacp (ylgixwstgm, obdrjgnioh - dgzomjparo)
Phase 2
19
(Cohort 1: SBRT and FOLFIRINOX)
eqilhbtprx(hqnuhmtphn) = fouhqsukzu ohccjywqat (ywxyqhlqix, wfgbhlboyy - tcqvyurynb)
-
14 Aug 2024
Stereotactic Body Radiation
(Cohort 2: SBRT and Modified FOLFIRINOX)
eqilhbtprx(hqnuhmtphn) = fsjcuabkss ohccjywqat (ywxyqhlqix, kyztxqgnua - jkvllqamjy)
Phase 1/2
9
aniqeyirgm(epkotdmywr) = ivmhnpjxgs fgpsjdqdjv (sppjktfkuu, foqnlkitoe - jrenyncqft)
-
09 Aug 2024
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