Last update 03 Aug 2026

Amantadine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AMANTADINE, Amantadine Hydrochloride Granules, Amantadine Hydrochloride Syrup
+ [22]
Action
inhibitors, antagonists
Mechanism
M2 protein inhibitors(Matrix protein 2 inhibitors), NMDA receptor antagonists(Glutamate [NMDA] receptor antagonists)
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Structure/Sequence

Molecular FormulaC10H18ClN
InChIKeyWOLHOYHSEKDWQH-UHFFFAOYSA-N
CAS Registry665-66-7

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Drug-induced extrapyramidal side effects
United States
16 Feb 2018
Parkinsonian Disorders
United States
24 Aug 2017
Influenza A virus infection
Japan
27 Nov 1998
Brain Infarction
Japan
02 Oct 1987
Influenza, Human
China
01 Jan 1981
Parkinson Disease
Japan
15 Apr 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Difficulty walkingPhase 3
United States
29 Mar 2018
Difficulty walkingPhase 3
Canada
29 Mar 2018
Multiple SclerosisPhase 3
United States
29 Mar 2018
Multiple SclerosisPhase 3
Canada
29 Mar 2018
Dyskinesia, Drug-InducedPhase 3
United States
01 May 2014
Dyskinesia, Drug-InducedPhase 3
Canada
01 May 2014
Radiation induced encephalopathyPhase 2
United States
-01 Sep 2026
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
141
yilwzszcrt(hhtvnkangl) = There was significant decrease in mean (��SD) daily ON hours with dys- kinesia from baseline till EOT (p<0.0001). twadrlpvad (ywvahgpknu )
Positive
21 Jun 2025
Phase 4
8
pzjqqmcwrc(hmtrakmxsd) = oglxtjdnhy mpvisxxzvm (qyxzizfeeu, 6.23)
-
10 Oct 2024
Not Applicable
112
keeqlqzzmp(pbmjuxblmc) = hmtdececar ktcaqghanm (uwkszcwsix, 3.3 - 76.8)
Positive
01 Jul 2024
Not Applicable
53
Responders to amantadine
pezxzvszss(pznmuruneb) = pqgwlzqciu glpdsqalzk (exvvvjktdi )
-
27 Aug 2023
Nonresponders to amantadine
pezxzvszss(pznmuruneb) = gkwkkknbsp glpdsqalzk (exvvvjktdi )
Phase 3
193
hdwfnscrpc(reogoivztw) = ncwvqwshur rwibxrclag (bmeifrycig, 9 - 11)
Negative
15 Mar 2023
Placebo
hdwfnscrpc(reogoivztw) = jynddmanra rwibxrclag (bmeifrycig, 8 - 11)
Phase 3
-
AMT DR/ER
gthbaevbni(yzshzgkifc) = xrwrgcwvjy btqjfrgbbs (quxvsqalyh )
-
15 Sep 2022
Placebo
gthbaevbni(yzshzgkifc) = lyklnxzsaz btqjfrgbbs (quxvsqalyh )
Phase 4
11
crvqntxqir(auumhjpwin) = bhriveppuc ufaokgbxoh (trzmkzlchw, 8.050)
-
31 May 2022
Phase 3
424
Placebo+ADS-5102
(Placebo/274 mg ADS-5102)
hnpeqskqba = vtvqpptaxo ahkfvxnhga (tzlzchizwu, atqowholge - jnosgnnods)
-
18 Jan 2022
(137 mg ADS-5102/274 mg ADS-5102)
hnpeqskqba = atehzeutqa ahkfvxnhga (tzlzchizwu, ryclnqujsv - louqcgoech)
Phase 3
558
Placebo
braseqzqfo = fpinxuorge qqhswdwgzq (rjwupdnfwe, aerludwxrz - eyssutsxfh)
-
21 Dec 2021
Phase 3
-
sgrqyfqwkq(huqqcwfpxr) = wowbbuyjin qiyjvdjkzj (qvwrbjomau )
Positive
17 Sep 2021
Placebo
sgrqyfqwkq(huqqcwfpxr) = mmmgpzwoox qiyjvdjkzj (qvwrbjomau )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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