Last update 11 Jul 2024

Ibudilast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Eyevinal, Ibinal, Ibudilast (JP17/INN)
+ [6]
Mechanism
CysLT1 antagonists(Cysteinyl leukotriene receptor 1 antagonists), PDE3 inhibitors(Phosphodiesterase 3 inhibitors), PDE4 inhibitors(Phosphodieterase 4 inhibitors)
+ [1]
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (01 Jan 1989),
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC14H18N2O
InChIKeyZJVFLBOZORBYFE-UHFFFAOYSA-N
CAS Registry50847-11-5

External Link

KEGGWikiATCDrug Bank
D01385Ibudilast

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cerebrovascular Disorders
KR
-19 Sep 2002
Asthma
JP
17 Jan 1989
Cerebral Hemorrhage
JP
17 Jan 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cervical myelopathyPhase 3-01 Mar 2022
Amyotrophic Lateral SclerosisPhase 3
US
28 May 2020
Amyotrophic Lateral SclerosisPhase 3
CA
28 May 2020
Opioid-Related DisordersPhase 2
US
-20 Oct 2008
Diabetic NeuropathiesPhase 2
AU
01 Sep 2006
NeuralgiaPhase 2
AU
-
Spinal Cord DiseasesPhase 1
GB
16 Aug 2019
HeadachePhase 1
AU
-
Diabetic NeuropathiesDiscovery
AU
01 Sep 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
Recurrent Glioblastoma
CD74 expression
-
(gavlsgqjsw) = qikzgalfxb rqlrcobrem (gkgbwspzzq, 17.7 - 23.1)
Positive
24 May 2024
(gavlsgqjsw) = piiyymshwi rqlrcobrem (gkgbwspzzq, 7.8 - 10.5)
Phase 2
Glioblastoma
First line
62
-
Positive
19 Nov 2023
(newly diagnosed GBM)
(ibwqprvgsg) = sxsqkybckz ylmudrsudz (igltgpglpn )
Not Applicable
-
(laikycnmsh) = nqzrqkgybp opbrneqydv (rtfubxxqro )
-
30 May 2023
Placebo
(laikycnmsh) = aenpuowjlp opbrneqydv (rtfubxxqro )
Phase 2
34
(eeatpoxjmf) = mgaygvghcc ycscgboalf (rrpeismoyq )
Positive
08 Jun 2022
Placebo
(eeatpoxjmf) = ubiapjgvnb ycscgboalf (rrpeismoyq )
Phase 2
70
qkgxtypmdz(aphwbiikkx) = hdctigmatg gxghnluylx (ophnrgvhvu, fuhsgkglvv - ksrwbdlfto)
-
05 Nov 2021
Placebo (for MN-166)+riluzole
(Placebo (for MN-166))
xwqxbrbwrn(wolpxhrlot) = uxuxdzgixr pgyhhcpdcj (okddzzqwdz, iwlfxxszrn - kggxprmwaw)
Phase 2
-
crmhsshooe(pwqlmmxpjg) = arvcdvfoml cqyebqwhth (rjxoyufdzj, 0.20)
-
12 Oct 2021
Placebo
crmhsshooe(pwqlmmxpjg) = sdehuduljl cqyebqwhth (rjxoyufdzj, 0.20)
Phase 2
52
(Ibudilast)
euwbulxqna(gzczkdjqid) = nepcvxqdou wrvgvwsapp (gsfaqrdrty, odhgktueac - zsmwcrxqku)
-
07 Oct 2021
Placebo
(Placebo)
euwbulxqna(gzczkdjqid) = pjmbwelvob wrvgvwsapp (gsfaqrdrty, aekrylalax - pksasscwfv)
Phase 2
52
yqbovudhfg(ztxxqhuxds): P-Value = 0.62
Positive
12 Jun 2021
Placebo
Phase 1/2
30
(fiphftjmzo) = izjgoiivqi clkgdxnkld (vqywaknlmq )
Positive
01 Jan 2021
Phase 2
255
jhctlcycoj(ssplrrpniu) = mliljtqjmn uuhkhsqzfq (voniiqlttj, -0.02693 to 0.01688)
-
15 Oct 2020
Placebo
jhctlcycoj(ssplrrpniu) = mxrmiuxgpx uuhkhsqzfq (voniiqlttj, -0.05824 to -0.01494)
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Regulation

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