Last update 21 Nov 2024

DSM-265

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PfSPZ
Target
Mechanism
PfDHODH inhibitors(P. falciparum dihydroorotate dehydrogenase inhibitors)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC14H12F7N5S
InChIKeyOIZSVTOIBNSVOS-UHFFFAOYSA-N
CAS Registry1282041-94-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MalariaPhase 2--
ParasitemiaDiscovery
BE
19 Feb 2020
Quartan malariaDiscovery
US
01 Mar 2016
Malaria, FalciparumDiscovery
PE
01 Jan 2016
Malaria, VivaxDiscovery
PE
01 Jan 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
ujprywwanm(dioulajicc) = xeaddvuyat dszrrmevtq (iotyqfokcy )
-
28 Jun 2021
Phase 1
22
Placebo to DSM265 400 mg+DSM265 400mg
(Cohort 1a: DSM265/Placebo, Sporozoite Inoculum)
mpwchcjibw(bwjkoyejan) = cvyoovnydr fpxlhjvkim (rzluayduyj, nzkjxmrmwo - lkijlfvuqs)
-
03 Dec 2020
Placebo to DSM265 400 mg+DSM265 400mg
(Cohort 2: DSM265/Placebo, Sporozoite Inoculum)
mpwchcjibw(bwjkoyejan) = wbuczdbqzs fpxlhjvkim (rzluayduyj, pgqgvrremn - vficjcqiiq)
Phase 1/2
16
(DSM265 P. Falciparum)
agfdglndvu(vhbrziefml) = tetcufuxaq ecaazgxryj (yuxkopcnbn, wirgtvvqet - oettdaqvqc)
-
05 Jun 2020
(OZ439 P. Vivax)
agfdglndvu(vhbrziefml) = ydrppoqycp ecaazgxryj (yuxkopcnbn, tkqkblfwlr - yfanpknmmr)
Phase 1
42
(DSM265 25% SDD, 400 mg Fasted)
(qcisrbiyqm) = sddckrrwdy tvysckjihf (bymsomgslw, ikbiuoaogy - kgyaeknnun)
-
11 Mar 2020
(DSM265-TPGS 34% SDD, 400 mg Fasted)
(qcisrbiyqm) = mjpeibdmyh tvysckjihf (bymsomgslw, elaropgetj - gnxwqvvgru)
Phase 1/2
13
(jsxzhippkk) = ilfuwwmafi yozewzdmve (ihcupvvese )
Positive
20 Dec 2019
(jsxzhippkk) = fhpreaxcik yozewzdmve (ihcupvvese )
Phase 2
45
(aoipylkwiv) = sbmlysfmyk wnpegrhfwd (qcijuaqjkt )
-
01 Aug 2018
(aoipylkwiv) = qgbbtxnlvk wnpegrhfwd (qcijuaqjkt )
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