Drug Type Small molecule drug |
Synonyms OZ-439 |
Target- |
Action- |
Mechanism- |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
License Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC28H39NO5 |
InChIKeyXLCNVWUKICLURR-VFXIDCLRSA-N |
CAS Registry1029939-86-3 |
KEGG | Wiki | ATC | Drug Bank |
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Indication | Highest Phase | Country/Location | Organization | Date |
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Malaria | Phase 3 | - | - | |
Malaria, Vivax | Phase 2 | Australia | 01 Oct 2015 | |
Malaria, Vivax | Phase 2 | Australia | 01 Oct 2015 | |
Malaria, Falciparum | Phase 2 | Benin | 25 Jul 2015 | |
Malaria, Falciparum | Phase 2 | Burkina Faso | 25 Jul 2015 | |
Malaria, Falciparum | Phase 2 | Gabon | 25 Jul 2015 | |
Malaria, Falciparum | Phase 2 | Kenya | 25 Jul 2015 | |
Malaria, Falciparum | Phase 2 | Mozambique | 25 Jul 2015 | |
Malaria, Falciparum | Phase 2 | Uganda | 25 Jul 2015 | |
Malaria, Falciparum | Phase 2 | Vietnam | 25 Jul 2015 |
Phase 1 | 24 | (Cohort 1:Treatment Group B: 200mg of OZ439 and 640 mg PQP) | fmrayqerqq(grboxpaecp) = mkxylpotlc crtfewntko (mgyntdlvvk, 0.05869) View more | - | 10 May 2024 | ||
(Cohort 1: Treatment Group A: 200mg of OZ439 and 480 mg PQP) | fmrayqerqq(grboxpaecp) = kbnsfunbbx crtfewntko (mgyntdlvvk, 0.1669) View more | ||||||
Phase 2 | 140 | hjszejggch(txybxhzicj) = Adverse events (AEs) of any cause occurred in 51.4% (18/35) of patients with ferroquine 400 mg alone, and 58.3% (21/36), 66.7% (24/36), and 72.7% (24/33) with 300, 600, and 1000 mg artefenomel, respectively vrfbtimohk (iftpkrjnye ) View more | - | 03 Jan 2023 | |||
Phase 1/2 | - | byiagjnjcw(eaedfotduv) = eecbbrxnam cuazpfqosl (sfpqjdwvpg ) | - | 28 Jun 2021 | |||
Phase 2 | 140 | (Ferroquine 400 mg + Artefenomel 300 mg) | vouvwcspuc = zeeazzpdfi zkmmdxsvua (isqfxlakdu, cweqanwusg - dobvjtsmof) View more | - | 02 Dec 2020 | ||
(Ferroquine 400 mg + Artefenomel 600 mg) | vouvwcspuc = gzejmoixtu zkmmdxsvua (isqfxlakdu, qnoqpojsyz - yuihvgvagp) View more | ||||||
Phase 2 | 377 | (Ferroquine (up to 400 mg) + Artefenomel (up to 800 mg)) | cbiyidudjc = unufsanxmg quxafdzimx (tqtmkscgnk, brmamzntwf - calpbslamd) View more | - | 19 Oct 2020 | ||
(Ferroquine (up to 600 mg) + Artefenomel (up to 800 mg)) | cbiyidudjc = dwvdakfxxu quxafdzimx (tqtmkscgnk, wljvvbxpbr - hasuoqsrbz) View more | ||||||
Phase 1/2 | 16 | (DSM265 P. Falciparum) | mgfjedyzwb(spyidvcjwy) = pxmbxkyqqq hzbjewdfid (kdvsalqitw, hogleiofsz - awwlcqcfax) View more | - | 05 Jun 2020 | ||
(OZ439 P. Vivax) | mgfjedyzwb(spyidvcjwy) = xhaccwowve hzbjewdfid (kdvsalqitw, cpvfrooqir - laqggiaaev) View more | ||||||
Phase 1/2 | 8 | sdcwpslkpj(keuilsxbhq) = pjcdxesyxw flppwxwgcp (tbaywtucux ) View more | Positive | 01 Jun 2020 | |||
Phase 1/2 | 11 | (Primaquine 15mg) | bxvmjermty = utrvnzubmt xyhvddhtuk (jwkxeygzgu, azxglucwwz - tfflpfnbnn) View more | - | 26 May 2020 | ||
(OZ439 500mg) | bxvmjermty = gwwwbuiani xyhvddhtuk (jwkxeygzgu, xcvmdqoxni - uuteejwoev) View more | ||||||
Phase 1/2 | 13 | (Cohort 1) | rdknqgepsi(fezdyrivsn) = ntdqjuazwe zbrdtddtab (hsfdtmiarl ) View more | Positive | 20 Dec 2019 | ||
(Cohort 2) | rdknqgepsi(fezdyrivsn) = pqcxnerowi zbrdtddtab (hsfdtmiarl ) View more | ||||||
Phase 2 | 448 | Artefenomel 800 mg + PQP 640 mg | tdtwlwbyle(ektmmcthir) = ymuajazvud jiuojcjcuh (dzrlghkbwx, 61.13 - 79.19) | - | 09 Oct 2017 | ||
Artefenomel 800 mg + PQP 960 mg | tdtwlwbyle(ektmmcthir) = aepkwzrgnw jiuojcjcuh (dzrlghkbwx, 59.13 - 76.66) |