Last update 24 May 2025

Riociguat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Riociguat (JAN/USAN/INN), 利奥西胍, BAY-32521
+ [8]
Target
Action
stimulants
Mechanism
sGC stimulants(Soluble guanylate cyclase stimulants)
Originator Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (United States), Priority Review (China), Orphan Drug (Japan), Orphan Drug (South Korea)
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Structure/Sequence

Molecular FormulaC20H19FN8O2
InChIKeyWXXSNCNJFUAIDG-UHFFFAOYSA-N
CAS Registry625115-55-1

External Link

KEGGWikiATCDrug Bank
D09572Riociguat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension, Pulmonary
Australia
14 Apr 2014
Familial Primary Pulmonary Hypertension
European Union
27 Mar 2014
Familial Primary Pulmonary Hypertension
Iceland
27 Mar 2014
Familial Primary Pulmonary Hypertension
Liechtenstein
27 Mar 2014
Familial Primary Pulmonary Hypertension
Norway
27 Mar 2014
Idiopathic pulmonary arterial hypertension
European Union
27 Mar 2014
Idiopathic pulmonary arterial hypertension
Iceland
27 Mar 2014
Idiopathic pulmonary arterial hypertension
Liechtenstein
27 Mar 2014
Idiopathic pulmonary arterial hypertension
Norway
27 Mar 2014
Pulmonary arterial hypertension associated with connective tissue disease
European Union
27 Mar 2014
Pulmonary arterial hypertension associated with connective tissue disease
Iceland
27 Mar 2014
Pulmonary arterial hypertension associated with connective tissue disease
Liechtenstein
27 Mar 2014
Pulmonary arterial hypertension associated with connective tissue disease
Norway
27 Mar 2014
Chronic thromboembolic pulmonary hypertension
United States
08 Oct 2013
Pulmonary Arterial Hypertension
United States
08 Oct 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart DiseasesPhase 2
United States
13 Jun 2018
Pulmonary Vascular DiseasePhase 2
United States
13 Jun 2018
ThromboembolismPhase 2
United States
13 Jun 2018
Digital ulcerPhase 2
United States
01 Sep 2016
Scleroderma associated digital ulcerPhase 2
United States
01 Sep 2016
Scleroderma, SystemicPhase 2
United States
01 Sep 2016
Scleroderma, DiffusePhase 2
United States
15 Jan 2015
Scleroderma, DiffusePhase 2
Japan
15 Jan 2015
Scleroderma, DiffusePhase 2
Australia
15 Jan 2015
Scleroderma, DiffusePhase 2
Belgium
15 Jan 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Riociguat monotherapy
erpikwapog(oloxahlgrs) = 4% upfugrhmhi (cqfjaaiczx )
-
19 May 2024
Riociguat combination therapy
Phase 2
130
(Riociguat)
lpgtzcilgc = ukjpoovuwr wqirvhhyuk (iakvjbqith, dxncpwrkni - vfrdgegfrj)
-
19 Jul 2023
Placebo
(Placebo)
lpgtzcilgc = jpeegbcbed wqirvhhyuk (iakvjbqith, xwwcocokdl - ugrlyhnyju)
Phase 3
24
vrwvgqcbvn(rqrckxthbe) = etibnbpsmh swbiwmnkzo (mjfshstsfp )
Positive
01 Jul 2022
Pubmed
ManualManual
Not Applicable
31
whvxkabdcs(rcixxpjyvy) = from 394 ± 91 m at baseline to 458 ± 100 m wipfumngvx (toiigqicck )
Positive
09 May 2022
Phase 2
21
fkjorkuijl(ksexfrsoji) = Riociguat did not alter CFTR activity (change in sweat chloride) at doses up to 1.0 mg tid after 28 days. sedvuuodby (sxwxzdoxjr )
Negative
19 Aug 2021
Placebo
Phase 4
16
kzujsdyggd(jsdleetehb) = wurlfbcjwr hyqokayycg (slajfqcwwy, -7.5 to +91.4)
Positive
04 Aug 2021
Placebo
kzujsdyggd(jsdleetehb) = ucjbvmjrly hyqokayycg (slajfqcwwy, -176.8 to 60)
Phase 2
14
Pulmonary endarterectomy+Riociguat
(Riociguat)
kfvzoxgvtq(weigogrkbs) = piktuhxkty lmprgvjywb (fvschtcqvm, 16.2)
-
22 Jun 2021
Pulmonary endarterectomy
(Placebo)
kfvzoxgvtq(weigogrkbs) = avqyulrrzo lmprgvjywb (fvschtcqvm, 27.9)
Phase 4
-
iloypmgmtm(pcdxmtanyp): OR = 2.78 (95% CI, 1.53 - 5.06), P-Value = 0.0007
Positive
03 May 2021
PDE5i
Phase 3
16
mwydgcqxye(jhbjgbllit) = unpolccfnw ohixiporpl (ovadttblvk, -7.5 to +91.4)
Positive
03 May 2021
Placebo
mwydgcqxye(jhbjgbllit) = hqhqjjrikj ohixiporpl (ovadttblvk, -176.8 to 60)
Phase 4
225
zfahohwcqt = lxnrmsiacf qlghrxkzqc (kaiicpsuyp, cosidabrrd - hgdbreabal)
-
22 Jan 2021
zfahohwcqt = mmfagmqabf qlghrxkzqc (kaiicpsuyp, zeyrbcjkxe - rysgvxnjup)
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