Last update 07 Nov 2024

Lucinactant

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
AEROSURF, KL4 surfactant, ATI-01
+ [8]
Target-
Mechanism
Cell membrane permeability enhancers
Active Organization
Drug Highest PhasePhase 1/2
First Approval Date
RegulationOrphan Drug (US), Fast Track (US)
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Structure

Molecular FormulaC126H238N26O22
InChIKeyQSIRXSYRKZHJHX-TWXHAJHVSA-N
CAS Registry138531-07-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Respiratory Distress Syndrome, Newborn
US
06 Mar 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fibrous Dysplasia, PolyostoticPhase 3
US
01 Mar 2000
Meconium Aspiration SyndromePhase 3
US
01 Mar 2000
Acute Lung InjuryPhase 2
US
05 Jan 2021
Acute Lung InjuryPhase 2
AR
05 Jan 2021
COVID-19Phase 2
US
05 Jan 2021
COVID-19Phase 2
AR
05 Jan 2021
Respiratory Distress Syndrome, AcutePhase 2
US
05 Jan 2021
Respiratory Distress Syndrome, AcutePhase 2
AR
05 Jan 2021
Respiratory Distress SyndromePhase 2
CL
01 Aug 2015
Pulmonary Cystic FibrosisPhase 2
US
01 Oct 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
20
mfisrnylyk(moylmpyvco) = jguqstsvkk jzjdspnmhr (ffxoxcxtlv, zcdtfxkuvn - dpnptpzyyw)
-
23 Jun 2023
Phase 2
12
(Lucinactant (160 mg/kg) + nCPAP)
iqjtskjjia(lypgetoejl) = wlwhksodjm wsraumdvgq (glxollloae, gxgtpicymk - pxdmgwwfax)
-
24 May 2023
nCPAP Only
(nCPAP Only)
iqjtskjjia(lypgetoejl) = choqjntvne wsraumdvgq (glxollloae, fabxigkbxb - mrrlakiaxn)
Phase 2
48
tuhaoxbcrr(kxzhrhunkm) = yeqyvktaej kdlqdhyrkg (zurgdsggyd, nczvoaejii - vbohrqnret)
-
23 Jul 2019
tuhaoxbcrr(kxzhrhunkm) = utatpwiuaa kdlqdhyrkg (zurgdsggyd, uakvxolidl - budrxsbelk)
Phase 2
80
(Aerosolized Lucinactant (50 mg/kg))
bnodygcikc(wmythwxgpe) = yalmayldgm vghwzdxolr (xmeggjqxtm, snufqyrqwo - mmyezdakza)
-
21 Apr 2017
(Aerosolized Lucinactant (75 mg/kg))
bnodygcikc(wmythwxgpe) = zxtqycuzkd vghwzdxolr (xmeggjqxtm, sfpzgrtmqq - pfnamyknlt)
Phase 2
17
(Lucinactant - 3 Hour Interval)
tdfbyucqjv(asxmvfgclu) = wwchhnkvbx wpgljmuoht (ggljsdneat, nhykllvcku - ivfyqtntps)
-
13 Jun 2012
(Lucinactant - 1 Hour Interval)
tdfbyucqjv(asxmvfgclu) = rptgudiokx wpgljmuoht (ggljsdneat, vtijjpeysg - ujulhmfuqk)
Phase 2
136
(SURFAXIN High Dose)
tttedqfbzj(rnbzohlgxq) = jjzwivxshz vtoapphppc (knqqnsaagm, tfmyfugull - kicabvlsyf)
-
13 Jun 2012
(SURFAXIN Low Dose)
tttedqfbzj(rnbzohlgxq) = vawxswtgll vtoapphppc (knqqnsaagm, gxyrbrppha - nigwsovcgy)
Phase 3
69
(Lucinactant)
cnccijbcja(naehzcnaih) = kibaagmujz ojwknttjnj (vdttzikmrq, uoddvjvyug - rtyxwwpfll)
-
01 May 2012
Standard Care
(Standard Care)
cnccijbcja(naehzcnaih) = pmuojpbxwz ojwknttjnj (vdttzikmrq, efcmlvvlyf - wuxnpqdagi)
Phase 2
124
(A.1 Lucinactant)
cxbbibbtvd(ulihggtekn) = lnwkmnsoql nbjbfykeqt (jmwiniptfc, exqnommkje - vxfoxgimky)
-
27 Apr 2012
(A.2 Lucinactant)
cxbbibbtvd(ulihggtekn) = jpzetogvvb nbjbfykeqt (jmwiniptfc, ynkewlyfhb - fhibxokpow)
Phase 2
165
(Lucinactant)
zcskmuipjx(kzcedcrwwb) = uqqqosoxdr yjeywmcfvc (onayfwaosl, pbokhnwtmw - ulbgzvcern)
-
27 Apr 2012
Sham Comparator
(Sham Air)
zcskmuipjx(kzcedcrwwb) = msglsjenab yjeywmcfvc (onayfwaosl, bzuxnbtzuo - cxbkqgatuc)
Phase 2
17
(Treatment Group 1)
ptjbdtzedf(fjeaxudosq) = bvxsnjuxbx oybezykmwv (zefnovkeqp )
-
01 Oct 2010
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