A Prospective, Single-arm, Open-label, Non-interventional, Multicenter, Post-marketing Surveillance to Assess the Safety and Effectiveness of Zirabev in Domestic Patients With Non-small Cell Lung Cancer, Metastatic Colorectal Cancer, Metastatic Breast Cancer, Advanced or Metastatic Kidney Cancer, Cervical Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer or Glioblastoma Multiforme.

This is a prospective, single-arm, open-label, non-interventional, multicenter, post-marketing surveillance to assess the safety and effectiveness of Zirabev(Bevacizumab biosimilar) in domestic patients with non-small cell lung cancer, metastatic colorectal cancer, metastatic breast cancer, advanced or metastatic kidney cancer, cervical cancer, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer or glioblastoma multiforme.

Start Date01 Sep 2024

Sponsor / Collaborator

Pfizer Inc.

NCT06448364 / RecruitingPhase 1

FIRST-IN-HUMAN (FIH), OPEN-LABEL, PHASE 1 DOSE ESCALATION AND EXPANSION STUDY DESIGNED TO EVALUATE THE SAFETY, TOLERABILITY, PK, PD, AND PRELIMINARY CLINICAL ACTIVITY OF PF-07329640 AS A SINGLE AGENT OR IN COMBINATION TREATMENT FOR PARTICIPANTS WITH ADVANCED SOLID TUMORS.

The purpose of this study is to learn about the safety (the impact of the study drug on the participant's body), effects of the study drug alone or in combination with bevacizumab or sasanlimab, and to find the best dose.
This study is seeking participants who have solid tumors that:
have advanced (cancer that doesn't disappear or stay away with treatment) or
has spread to other parts of the body (metastatic).
This includes (but limited to) the following cancer types:
Non-Small Cell Lung Cancer (NSCLC): It's a type of lung cancer where the cells grow slowly but often spread to other parts of the body.
Colorectal Cancer (CRC): This is a disease where cells in the colon or rectum grow out of control.
Urothelial Cancer (UC): This is a cancer that starts in the urinary systems.
Melanoma: Skin cancer that develops when melanocytes (the cells that give the skin its tan or brown color) start to grow out of control.
All participants in this study will receive the study medication (PF-07329640) as an IV infusion (given directly into a vein) at the study clinic every week for repeating 28-day cycles.
Depending on which part of the study participants are enrolled in they will receive the study medication (PF-07329640 alone or in combination with other anti-cancer medications (bevacizumab or sasanlimab). Bevacizumab is given in the clinic as IV infusion every two weeks and sasanlimab is given as a shot under the skin every 4 weeks.
Participants can continue to take the study medication (PF-07329640) and bevacizumab until their cancer is no longer responding. Participants who are taking sasanlimab may receive it for up to 2 years.
The study will look at the experiences of people receiving the study medicines. This will help see if the study medicines are safe and effective.
Participants will be involved in this study for up to 4 years. During this time, they will have a study visit every week. After they have stopped taking the study medication (at about at 2 years) they will be followed for another two years to see how they are doing.

Start Date09 May 2024

Sponsor / Collaborator

Pfizer Inc.

NCT05601973 / RecruitingPhase 2

A Multicentre Single-arm Phase II Trial of Amivantamab, Lazertinib Plus Bevacizumab in Patients With EGFR-mutant Advanced NSCLC With Progression on Previous Third-generation EGFR-TKI

AMAZE-lung is a multicenter single-arm phase II trial. The protocol treatment consists of amivantamab, lazertinib and bevacizumab (Zirabev®), given in a three-weekly regimen. The primary objective of the trial is to assess the efficacy of amivantamab and bevacizumab added to continued treatment with the third-generation EGFR-TKI lazertinib, in patients with EGFR-mutant advanced NSCLC, who have been previously treated with a third-generation EGFR-TKI in order to provide data on treatment effect and sample size required for a future phase III trial.
In addition, the safety of the treatment combination will be evaluated.

Start Date27 Mar 2023

Sponsor / Collaborator

European Thoracic Oncology Platform

[+1]

100 Clinical Results associated with Bevacizumab-BVZR

100 Translational Medicine associated with Bevacizumab-BVZR

100 Patents (Medical) associated with Bevacizumab-BVZR

107

Literatures (Medical) associated with Bevacizumab-BVZR

01 Feb 2024·Colloids and surfaces. B, Biointerfaces

A comparison between the effects of two liposome-encapsulated bevacizumab formulations on ocular neovascularization inhibition

Article

Author: Morshedi, Dina ; Elahi, Elahe ; Bardania, Hassan ; Malakouti-Nejad, Maryam ; Monti, Daniela ; Burgalassi, Susi

Bevacizumab (BVZ), an anti-VEGF antibody, has demonstrated reliable outcomes in the treatment of irritating ocular neovascularization. Frequent intravitreal injections are necessitated due to rapid clearance and short local accessibility. We recruited liposome as a highly prevailing drug delivery system to enhance drug availability. Two liposome formulations were characterized and their in vitro stability was analyzed. The toxicity of the formulations on some ocular cell lines was also evaluated. In addition, the anti-angiogenic effects of formulations were examined. Drug permeation was measured across ARPE-19 and HCE cell lines as in vitro cellular barrier models. Results revealed that NLP-DOPE-BVZ acquired high stability at 4 °C, 24 °C, and 37 °C for 45 days. It also showed more capacity to entrap BVZ in NLP-DOPE-BVZ (DEE% 69.1 ± 1.4 and DLE% 55.66 ± 1.15) as compared to NLP-BVZ (DEE% 43.57 ± 14.64, and DLE% 37.72 ± 12.01). Although both formulations inhibited the migration and proliferation of HUVECs, NLP-DOPE-BVZ was more effective at inhibiting angiogenesis. Furthermore, NLP-DOPE-BVZ better crossed our established barrier cellular models. Based on the findings, the inclusion of DOPE in NLPs has significantly enhanced the features of drug carriers. This makes them a potential candidate for treating ocular neovascularization and other related ailments.

04 Jan 2024·Journal of AOAC International

Stability and Biosimilarity Assessment of Bevacizumab Monoclonal Antibody; Orthogonal Testing Protocol Coupled With Peptide Mapping–Principal Component Analysis

Article

Author: Hegazy, Maha A ; Eltanany, Basma M ; Abdelghaffar, Sara H

Abstract:

Background:

Biologics are essential in cancer treatment because they stimulate the body’s natural response to fight cancer, but they are expensive. Biosimilars are more affordable compared to patent biologicals, but it must be verified that they are as effective as their innovators. Characterization of biosimilars and assessment of interchangeability requires many data points for verification.

Objective:

The proposed study provides a quality assessment of two new bevacizumab (BVZ) biosimilars, produced by Amgen and Biocad, Inc., through the development and greenness assessment of an orthogonal testing protocol and purity indicating assay, including size-exclusion (SE-HPLC), reversed-phase (RP-HPLC), and cation exchange chromatography (CEX-HPLC) in addition to dynamic light scattering (DLS) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).

Methods:

SE-HPLC method was performed and validated to screen the BVZ monomer and its aggregates and/or fragments. Peak purity and system suitability parameters were calculated. Results indicate that the orthogonal protocol is a useful tool for assessing monoclonal antibody stability. It is a key criterion for biosimilarity assessment. DLS and SDS-PAGE results were compared to each other to reveal close retention times and banding patterns between BVZ innovator and its biosimilars. These results showed that Avastin® and the investigated biosimilars have the same profile in terms of peak area of related compounds within the acceptance limit and apparent molecular weight, and the SDS-PAGE technique was found to be the most eco-friendly technique among others.

Conclusions:

The results obtained highlighted the importance of assessing similarities and differences in ensuring the biosimilarity and interchangeability of the studied products.

Highlights:

BVZ is one of the essential monoclonal antibodies in the treatment of colorectal cancer (CRC). BVZ biosimilars were evaluated by developing an orthogonal testing protocol and a purity-indicating assay. The size-exclusion (SE)-HPLC method was applied and validated to monitor the BVZ monomer and its aggregates. The results demonstrated the importance of assessing the stability and biosimilarity of BVZ.

01 Jan 2024·Journal of neuro-oncology

The utility of arterial spin labeling imaging for predicting prognosis after a recurrence of high-grade glioma in patients under bevacizumab treatment

Article

Author: Hosoya, Tomohiro ; Ochiai, Ryoya ; Kambe, Atsushi ; Fujii, Shinya ; Kurosaki, Masamichi ; Kitao, Shinichiro

BACKGROUND AND PURPOSE:

Currently, the antiangiogenic agent bevacizumab (BVZ) is used as a treatment option for high-grade glioma (HGG) patients. However, BVZ restores disruptions of the blood-brain barrier, which leads to the disappearance of contrast enhancement during radiological examinations and therefore complicates evaluations of treatment efficacy. This study aimed to investigate the radio-morphological features of recurrent lesions that newly appeared under BVZ therapy, as well as the utility of arterial spin labeling (ASL) perfusion imaging for evaluating treatment response and prognosis in HGG patients receiving BVZ.

METHODS:

Thirty-two patients (20 males, 12 females; age range, 35-84 years) with HGG who experienced a recurrence under BVZ therapy were enrolled. We measured the relative cerebral blood flow (rCBF) values of each recurrent lesion using ASL, and retrospectively investigated the correlation between rCBF values and prognosis.

RESULTS:

The optimal rCBF cut-off value for predicting prognosis was defined as 1.67 using receiver operating characteristic curve analysis. The patients in the rCBF < 1.67 group had significantly longer overall survival (OS) and post-progression survival (PPS) than those in the rCBF ≥ 1.67 group (OS: 34.0 months vs. 13.0 months, p = 0.03 and PPS: 13.0 months vs. 6.0 months, p < 0.001, respectively).

CONCLUSION:

The ASL-derived rCBF values of recurrent lesions may serve as an effective imaging biomarker for prognosis in HGG patients undergoing BVZ therapy. Low rCBF values may indicate that BVZ efficacy is sustainable, which will influence BVZ treatment strategies in HGG patients.

News (Medical) associated with Bevacizumab-BVZR

07 Mar 2024

·www.prnewswire.com

United States Biosimilar industry Outlook to 2028, Featuring Pfizer, Amgen, Biogen, Viatris and Coherus Biosciences

DUBLIN, March 7, 2024 /PRNewswire/ -- The "US Biosimilar industry outlook to 2028" report has been added to ResearchAndMarkets.com's offering. The US Biosimilar Industry is anticipated to grow at a CAGR of ~40% in the next five years owing to the cost-effective nature of Biosimilar drugs, rising geriatric population, increasing cases of chronic diseases and growing strategic partnerships. The US Biosimilar market is significantly growing due to various reasons such as rising geriatric population, cost effective nature of Biosimilar drugs, increasing cases of chronic diseases and growing strategic partnerships. Biosimilar drugs also tend to be cost effective. The geriatric population in the US has been constantly rising. The ageing population went from ~25,000 per 100,000 people in 1980s to ~54,000 per 100,000 people in 2020s. Most of the aged people cannot afford original drugs and thus, rising geriatric population raises the demand for Biosimilar drugs. Moreover, the cases of chronic diseases also have been rising in the US over the years. In 2020, there were at least 155 million people living with a chronic disease in the US. Such high number of chronic illness cases also raise the demand for the development of cost-effective medicines in the form of Biosimilar drugs. Key trends by Market Segment: By Drug class: In 2022, Monoclonal Antibodies continued to dominate the US Biosimilar Market. These antibodies can be best described as proteins developed in laboratories that are known to act like actual antibodies present in our blood. The reason behind their dominance is that they have been very successful when it comes to treating life threatening diseases such as cancers. Moreover, a treatment involving these antibodies happens to be more precise than any other treatment. Furthermore, these antibodies are known for activating the immune responses for fighting a particular disease. Due to their success rates and ability to stimulate immune responses, they have gained quite a popularity in the US Biosimilar market. By Application: In 2022, Oncology segment dominated the US Biosimilar market. The cancer cases have been rapidly rising in the United States over the years. In 2022, the United State witnessed almost 2 million cancer cases. The rising cases of cancer also results in the demand for the development of effective and efficient treatment of cancer. Monoclonal Antibodies that are used in Biosimilar drugs also have a 58% success rate in treating cancer. Overall, Biosimilar drugs are widely used in the treatment of various types of cancers such as breast cancer, lung cancer, colorectal cancer, etc. There are many Biosimilar drugs such as Zirabev, Truxima, Ogiviri, Releuko, Fulphila, Retacrit, etc which are used in the effective and efficient treatment of Cancer. By Geography: In 2022, the northern region of US happened to be the dominant segment in the US Biosimilar market. The main reason behind its dominance is the presence of Biosimilar drugs manufacturing companies, presence of many other healthcare companies and top-notch hospitals of the country. This is primarily due to the reason that this region witnesses the major healthcare companies of Biosimilar market in the country such as Amgen, Pfizer, Viartis, Biogen, Coherus Biosciences etc. Overall, there are almost 9000 healthcare companies established in this area. Due to the presence of vast number of companies, this region contributes to the growth of US Biosimilar market greatly. There are also many reputed hospitals located in this area such as Mayo Clinic, Cleveland Clinic, Memorial Sloan Kettering Cancer Centre, Dana Farber Cancer Institute, Hospitals of University of Pennsylvania, Northwestern Memorial Hospital, Barns-Jewish Hospital, etc. As more and more people visits these hospitals, the healthcare professionals get to know the requirements and demands of the Biosimilar drugs thereby accelerating the US Biosimilar Market. Future Outlook: The US Biosimilar Market is anticipated to witness a growth at a CAGR of 40% between the time period 2022-2028 owing to the rising cases of chronic diseases, rising geriatric population and increasing cases of cancer along with growing strategic partnerships among pharmaceutical companies. The prevalence of chronic diseases have been constantly rising in the United States. In 2020, there were at least 155 million people living with a chronic disease. This number is futher projected to reach 165 million and 170 million in 2025 and 2030 respectively. With rapidly rising cases, the demand for biosimilar drugs will be rising thereby driving the US Biosimilar market. The rising geriatric population also increases the demand for Biosimilar drugs. In the US, the geriatric population has increased from 25 per 100 people in the 1980s to 54 per 100 people in 2020. This number is further anticipated to reach 72 per 100 people in 2030s. With rising geriatric population, the demand for Biosimilar drugs rises as aged population is less likely to afford generic drugs. The rising cases of cancer also have resulted in an increased demand for Biosimilar drugs. Cancer has been rapidly rising in the US with around 2 million cases in 2020. The number is only projected to further increase. Moreover, most of the Biosimilar drugs are used in oncology so the rising cases only increases the demand for Biosimilar drugs thereby fueling the US Biosimilar market. Key Topics Covered: 1. Executive Summary 2. US Biosimilar Market Overview 2.1 Taxonomy of the Market 2.2 Industry Value Chain 2.3 Ecosystem 2.4 Government Regulations/Initiatives for the Market 2.5 Growth Drivers of the US Biosimilar Market 2.6 Issues and Challenges of the US Biosimilar Market 2.7 Impact of COVID-19 on US Biosimilar Market 2.8 SWOT Analysis 3.US Biosimilar Market Size, 2017 - 2022 4. US Biosimilar Market Segmentation 4.1 By Drug Class, 2017 - 2022 4.2 By Application 2017 - 2022 4.3 By Regional Split (North/East/West/South/Central), 2017 - 2022 5. Competitive Landscape 5.1 Mergers and Acquisitions, Joint Ventures, Collaborations, and Agreements 5.2 Strategies Adopted by Leading Players 5.3 Company Profiles Pfizer Amgen Biogen Viatris Coherus Biosciences 6. US Biosimilar Market, 2022-2028 7. US Biosimilar Market, Market Segmentation 7.1 By Drug class, 2022 - 2028 7.2 By Application, 2022 - 2028 7.3 By Regional Split (North/East/West/South/Central), 2022 - 2028 8. Analyst Recommendations For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

Biosimilar

02 Mar 2023

·www.biospace.com

Lantern Pharma Expands Clinical Leadership Team to Further Advance its Ongoing and Upcoming Clinical Trials

DALLAS--(BUSINESS WIRE)-- Lantern Pharma, Inc. (NASDAQ: LTRN), a clinical stage biopharmaceutical company using its proprietary RADR® artificial intelligence (AI) and machine learning (ML) platform to transform the cost, pace, and timeline of oncology drug discovery and development, today announced that it has expanded its clinical development team with the addition of Dr. Reggie Ewesuedo M.D., M.Sc., MBA, as Vice President of Clinical Development, and several additional team members. The expansion of the clinical development team will continue to advance the Harmonic™ trial, a Phase 2 trial for never smokers with NSCLC, as well as the upcoming first-in-human Phase 1 clinical trials for Lantern’s drug candidates LP-184 and LP-284, which are both anticipated to launch in mid-2023. “We are looking forward to the many contributions that Dr. Ewesuedo and our expanded clinical development team will bring to Lantern and our clinical programs,” said Panna Sharma, Lantern’s President and CEO. “They are joining Lantern at a pivotal period in our company’s growth as we advance our drug candidates into and through clinical trials. I am confident in the decades of proven experience of our new team members and their ability to progress Lantern’s drug candidates to improve the lives of cancer patients,” continued Sharma. Dr. Ewesuedo has over 20 years of experience in preclinical, early, and late phase drug development including roles in clinical development leadership at AstraZeneca, Genzyme/Sanofi, Pfizer, Tesaro/GlaxoSmithKline, and Kymera. His leadership and experience have led to the development of several drugs including the successful filings for Trazimera™ (trastuzumab), Nyvepria™ (pegfilgrastim), and Zirabev™ (bevacizumab), while he was at Pfizer. In addition to his industry experience, he also served as a clinical research faculty member at The Ohio State University from 2000-2005. He holds an M.D. from the University of Ibadan, College of Medicine, Ibadan, Nigeria, a M.Sc. in Pharmacology from Ahmadu Bello University, Zaria, Nigeria, and an MBA from St. Mary’s University, Greehey Business School, San Antonio, TX. Dr. Ewesuedo completed his subspecialties training in Hematology and Pediatric Oncology, and Clinical Pharmacology and Pharmacogenomics, at the University of Chicago. Lantern has also recently appointed Ernest Kitt as Head of Clinical Operations. Mr. Kitt has over 20 years of experience in oncology drug development and clinical operations with proven success in bringing drugs to market. He has held clinical oncology leadership positions at companies including Amgen/Onyx, Aptose, and Biosplice. Other additions to the clinical development team include Annum Zhara as a Senior Clinical Trial Project Manager and Brianna MacCrory as a Clinical Trial Navigator. About Lantern Pharma: Lantern Pharma (NASDAQ: LTRN) is a clinical-stage oncology-focused biopharmaceutical company leveraging its proprietary RADR® AI and machine learning platform to discover biomarker signatures that identify patients most likely to respond to its pipeline of genomically-targeted therapeutics. By targeting drugs to patients whose genomic pro them as having the highest probability of benefiting from the drug, Lantern's approach represents the potential to deliver best-in-class outcomes. Forward-looking Statements: This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These forward-looking statements include, among other things, statements relating to: future events or our future financial performance; the potential advantages of our RADR® platform in identifying drug candidates and patient populations that are likely to respond to a drug candidate; our strategic plans to advance the development of our drug candidates and antibody drug conjugate (ADC) development program; estimates regarding the development timing for our drug candidates and ADC development program; expectations and estimates regarding clinical trial timing and patient enrollment; our research and development efforts of our internal drug discovery programs and the utilization of our RADR® platform to streamline the drug development process; our intention to leverage artificial intelligence, machine learning and genomic data to streamline and transform the pace, risk and cost of oncology drug discovery and development and to identify patient populations that would likely respond to a drug candidate; estimates regarding patient populations, potential markets and potential market sizes; sales estimates for our drug candidates and our plans to discover and develop drug candidates and to maximize their commercial potential by advancing such drug candidates ourselves or in collaboration with others. Any statements that are not statements of historical fact (including, without limitation, statements that use words such as "anticipate," "believe," "contemplate," "could," "estimate," "expect," "intend," "seek," "may," "might," "plan," "potential," "predict," "project," "target," "model," "objective," "aim," "upcoming," "should," "will," "would," or the negative of these words or other similar expressions) should be considered forward-looking statements. There are a number of important factors that could cause our actual results to differ materially from those indicated by the forward-looking statements, such as (i) the impact of the COVID-19 pandemic, (ii) the risk that our research and the research of our collaborators may not be successful, (iii) the risk that none of our product candidates has received FDA marketing approval, and we may not be able to successfully initiate, conduct, or conclude clinical testing for or obtain marketing approval for our product candidates, (iv) the risk that no drug product based on our proprietary RADR® AI platform has received FDA marketing approval or otherwise been incorporated into a commercial product, and (v) those other factors set forth in the Risk Factors section in our Annual Report on Form 10-K for the year ended December 31, 2021, filed with the Securities and Exchange Commission on March 10, 2022. You may access our Annual Report on Form 10-K for the year ended December 31, 2021 under the investor SEC filings tab of our website at or on the SEC's website at . Given these risks and uncertainties, we can give no assurances that our forward-looking statements will prove to be accurate, or that any other results or events projected or contemplated by our forward-looking statements will in fact occur, and we caution investors not to place undue reliance on these statements. All forward-looking statements in this press release represent our judgment as of the date hereof, and, except as otherwise required by law, we disclaim any obligation to update any forward-looking statements to conform the statement to actual results or changes in our expectations.

Phase 1Phase 2Executive Change

28 Sep 2022

·endpts.com

Another Avastin biosimilar joins the party as Roche's grip on the market loosens

Avastin has attracted quite the crowd of biosimilars in recent years, and one more pharma company has elbowed its way in. Regulators on Wednesday approved Celltrion’s biosimilar Vegzelma in six cancer types, including metastatic colorectal cancer; recurrent or metastatic non-squamous non-small cell lung cancer (nsNSCLC); recurrent glioblastoma; metastatic renal cell carcinoma; persistent, recurrent, or metastatic cervical cancer; and epithelial ovarian, fallopian tube or primary peritoneal cancer. The label is notably missing hepatocellular carcinoma (HCC), which Avastin was approved to treat in combination with Tecentriq back in 2020. Vegzelma is Celltrion’s third cancer biosimilar approved in the US. In the last two months, the drug had already won approval in the EU, UK and Japan. However, the drug is a bit late to the party, as a handful of Avastin biosimilars have gone to market in recent years, including Amgen’s Mvasi, Pfizer’s Zirabev, and Amneal Pharmaceuticals and mAbxience’s Alymsys. Avastin sales have plummeted from $7 billion-plus heights since Amgen’s contender hit the market in 2019. Mvasi was approved in 2017, marking the first biosimilar cleared for the treatment of cancer in the US. Amgen rolled out the drug at a 15% discount from Avastin, charging $677.40 per 100 mg and $2,709.60 per 400 mg. Chasing Roche's aging blockbuster franchise, Amgen/Allergan roll out Avastin, Herceptin knockoffs at discount Last year, Avastin raked in a mere $3.1 billion in the US, down 37% due to sales “strongly impacted” by the uptake of biosimilars, the company reported. Meanwhile, Outlook Therapeutics is looking to bring a bevacizumab biosimilar, the active compound in Avastin, to market for ophthalmic indications. The company withdrew a BLA back in May for wet AMD after the FDA requested additional information, then resubmitted last month. Microcap's effort to take on Eylea with Avastin biosimilar faces significant FDA roadblock Analysts at Cardinal Health called last year one of the “most eventful” in US biosimilars’ history, noting milestones such as Viatris’ Semglee as the first interchangeable biosimilar and the first OK for a biosimilar in ophthalmology, Biogen’s Byooviz. Researchers say biosimilars are on track to reduce US drug expenditure by $133 billion by 2025. Momentum is “stronger than ever,” specialty solutions president Heidi Hunter told Endpoints News back in February, adding that this year could be a “turning point.”

Biosimilar

100 Deals associated with Bevacizumab-BVZR

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	L01XC07	DB00112

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Glioma	JP	Pfizer Japan, Inc.	13 Dec 2023
Breast Cancer	JP	Pfizer Japan, Inc.	28 Aug 2023
Ovarian Cancer	JP	Pfizer Japan, Inc.	28 Aug 2023
Fallopian Tube Carcinoma	US	Pfizer Inc.	09 Feb 2021
Ovarian Epithelial Carcinoma	US	Pfizer Inc.	09 Feb 2021
Primary peritoneal carcinoma	US	Pfizer Inc.	09 Feb 2021
Advanced Lung Non-Small Cell Carcinoma	JP	Pfizer Japan, Inc.	23 Sep 2020
Metastatic Colorectal Carcinoma	US	Pfizer Inc.	27 Jun 2019
Metastatic Renal Cell Carcinoma	US	Pfizer Inc.	27 Jun 2019
Non-squamous non-small cell lung cancer	US	Pfizer Inc.	27 Jun 2019
Recurrent Glioblastoma	US	Pfizer Inc.	27 Jun 2019
Colorectal Cancer	JP	Pfizer Japan, Inc.	18 Jun 2019
Colonic Cancer	EU	Pfizer Europe MA EEIG	14 Feb 2019
Colonic Cancer	IS	Pfizer Europe MA EEIG	14 Feb 2019
Colonic Cancer	LI	Pfizer Europe MA EEIG	14 Feb 2019
Colonic Cancer	NO	Pfizer Europe MA EEIG	14 Feb 2019
Metastatic breast cancer	EU	Pfizer Europe MA EEIG	14 Feb 2019
Metastatic breast cancer	IS	Pfizer Europe MA EEIG	14 Feb 2019
Metastatic breast cancer	LI	Pfizer Europe MA EEIG	14 Feb 2019
Metastatic breast cancer	NO	Pfizer Europe MA EEIG	14 Feb 2019

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced Lung Non-Squamous Non-Small Cell Carcinoma	Phase 3	CN	Pfizer Biologics (Hangzhou) Co., Ltd	11 Jun 2020
Advanced Lung Non-Squamous Non-Small Cell Carcinoma	Phase 3	CN	Global Life Sciences Technologies (Shanghai) Co. Ltd.	11 Jun 2020
Advanced Lung Non-Small Cell Squamous Carcinoma	Phase 3	US	Pfizer Inc.	01 Apr 2015
Advanced Lung Non-Small Cell Squamous Carcinoma	Phase 3	JP	Pfizer Inc.	01 Apr 2015
Advanced Lung Non-Small Cell Squamous Carcinoma	Phase 3	AU	Pfizer Inc.	01 Apr 2015
Advanced Lung Non-Small Cell Squamous Carcinoma	Phase 3	BR	Pfizer Inc.	01 Apr 2015
Advanced Lung Non-Small Cell Squamous Carcinoma	Phase 3	BG	Pfizer Inc.	01 Apr 2015
Advanced Lung Non-Small Cell Squamous Carcinoma	Phase 3	CL	Pfizer Inc.	01 Apr 2015
Advanced Lung Non-Small Cell Squamous Carcinoma	Phase 3	HR	Pfizer Inc.	01 Apr 2015
Advanced Lung Non-Small Cell Squamous Carcinoma	Phase 3	CZ	Pfizer Inc.	01 Apr 2015

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02364999 (Pubmed \| Cancer Chemother Pharmacol)	Phase 3	Advanced Lung Non-Squamous Non-Small Cell Carcinoma	719	PF-06439535	yeveorwxae(unvvlemjwc) = bolexddgxa jwabdynsga (peleplscbu ) View more	-	01 Mar 2020
NCT02364999 (Pubmed \| BioDrugs)	Phase 3	Advanced Lung Non-Squamous Non-Small Cell Carcinoma First line	719	PF-06439535 plus paclitaxelPF-06439535 plus paclitaxel and carboplatin	njpbulfmmq(exlmdfadfv) = ycvalpgrio evcrsawlwz (sragbrogyg, 40.01 - 50.57)	-	01 Oct 2019
				bevacizumab-EU plus paclitaxelbevacizumab-EU plus paclitaxel and carboplatin	njpbulfmmq(exlmdfadfv) = kfufhchkyo evcrsawlwz (sragbrogyg, 39.40 - 49.89)
NCT02364999 (CTgov)	Phase 3	Advanced Lung Non-Small Cell Squamous Carcinoma \| Non-squamous non-small cell lung cancer	719	Carboplatin+Paclitaxel+Bevacizumab-EU	xjiwrdmsbs(qvbxxjhxaz) = dwicfgedsh cjaytrhdaj (qcutyhjher, rzsmxoxypq - vsfkqrrweg) View more	-	27 Jun 2018
NCT02364999 (ASCO2018) Manual	Phase 3	Non-squamous non-small cell lung cancer First line	719	paclitaxel+carboplatin+PF-06439535	ndbxtbinyu(fkneqbnoxh) = owwydwdviw ipsvwjwsss (xjgpmngazf, 40.01 - 50.57) View more	Similar	04 Jun 2018
				paclitaxel+carboplatin+bevacizumab	ndbxtbinyu(fkneqbnoxh) = mgstcvgtsp ipsvwjwsss (xjgpmngazf, 39.40 - 49.89) View more
NCT02031991 (REFLECTIONS B739-01, WCLC2015)	Phase 1	First line	102	PF-06439535	vkszmxghgy(wfmqmjiwyf) = gjputngbcy gshgreuusi (bxmbrjnjec, 876)	-	07 Sep 2015
				Bevacizumab-EU	vkszmxghgy(wfmqmjiwyf) = teczwlgxzk gshgreuusi (bxmbrjnjec, 2260)

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