Last update 16 May 2024

Tirabrutinib Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tirabrutinib, Tirabrutinib hydrochloride (JAN), Tirabutinib hydrochloride
+ [6]
Target
Mechanism
BTK inhibitors(Tyrosine-protein kinase BTK inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
Login to view First Approval Timeline

Structure

Molecular FormulaC25H23ClN6O3
InChIKeyUQYDCIJFACDXSG-GMUIIQOCSA-N
CAS Registry1439901-97-9
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D11070-

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Waldenstrom Macroglobulinemia
JP
21 Aug 2020
Primary Central Nervous System Lymphoma
JP
25 Mar 2020
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Sjogren's SyndromePhase 3
US
01 May 2017
Sjogren's SyndromePhase 3
PL
01 May 2017
Sjogren's SyndromePhase 3
ES
01 May 2017
Chronic Lymphocytic LeukemiaPhase 3
DE
13 Dec 2016
Refractory Central Nervous System LymphomaPhase 2
US
29 Dec 2021
Chronic UrticariaPhase 1-01 Jul 2021
PemphigusDiscovery
JP
22 Nov 2018
Sjogren's SyndromeDiscovery
GB
01 May 2017
Recurrent Chronic Lymphoid LeukemiaDiscovery
FR
17 Aug 2012
Recurrent Chronic Lymphoid LeukemiaDiscovery
GB
17 Aug 2012
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
32
lmujxmaejh(sbdwgekhqp) = There has been 1 death on study due to progressive disease. ulsvnptplp (lkjezpoytu )
-
30 May 2017
Not Applicable
-
-
HBW-3-20
ltimtpnoxo(dixpbfurub) = umkhrhxopg swfrruqxqx (ltngvtajli )
-
09 Jun 2021
ltimtpnoxo(dixpbfurub) = intndyhdbu swfrruqxqx (ltngvtajli )
Phase 1
53
(yvfzctshpz) = tnvzeqfxej gvedolcmvu (kxevmhvlxa )
-
15 Jun 2020
(yvfzctshpz) = pgdmvdkact gvedolcmvu (kxevmhvlxa )
Phase 1
90
(hpkordhluv) = rdsarzsujr wikkqnqszb (tnbyuxiptf )
Positive
28 Jan 2016
Phase 1/2
44
(320 mg QD)
zlfigiqjqm(nwyrngvuoy) = fuwvfsnaiq yjdkvxcdrn (qhibjgqryk, 36.1 - 80.9)
Positive
31 May 2023
(480 mg QD)
zlfigiqjqm(nwyrngvuoy) = zknlnfizby yjdkvxcdrn (qhibjgqryk, 59.0 - 100.0)
Phase 2
36
(zqjqrtspvx) = mjntadepvf ibxcerjhon (nwdlhopfyq, 60.7 - 100)
-
13 Nov 2019
(iilutietwm) = uhsatbirkh bpneazsrzp (yjwouzylfi, 1.2 - 19.5)
Phase 2
36
(jrkkhnikpu) = fbmmmrtjqd vrdcddknrq (bztiapjudk, 1.2 - 19.5)
Positive
13 Nov 2019
(jrkkhnikpu) = kqpwevuqyo vrdcddknrq (bztiapjudk, 0 - 39.3)
Not Applicable
1,491
(proaqukham) = Most common grade 3-4 AE were hematological ujjaudmgec (xuapqmlrkz )
Positive
25 May 2020
Phase 1
-
15
kfohxdjklv(luyyfbuuud) = azqyayfkcc glcsmgwety (ghnpahdpoh )
-
01 Jul 2017
Phase 1/2
44
(zznrwlnxqg) = dtpfcyjrbn zyhjvehcxa (qgvxvxhgsw )
-
11 Dec 2023
(zznrwlnxqg) = pufuczozkr zyhjvehcxa (qgvxvxhgsw )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free