Delving into the Latest Updates on Omega-3-Carboxylic Acids with Synapse

This is a two-arm, double blind randomized 12-week study to supplement omega-3 (Eicosapentaenoic acid - EPA + docosahexaenoic acid - DHA) among 100 adults (age 18+) who had coronavirus-19 (covid-19) and are experiencing possible after-effects from post-acute sequelae of covid-19 (also called post-covid syndrome or long covid syndrome).

Start Date10 Jan 2022

Sponsor / Collaborator

Ocean Medical Center Association, Inc.

100 Clinical Results associated with Omega-3-Carboxylic Acids

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100 Translational Medicine associated with Omega-3-Carboxylic Acids

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100 Patents (Medical) associated with Omega-3-Carboxylic Acids

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99,795

Literatures (Medical) associated with Omega-3-Carboxylic Acids

31 Dec 2025·Energy Sources Part A-Recovery Utilization and Environmental Effects

Production and characterization of biodiesel from Jatropha (Jatropha curcas) seed oil available in Bangladesh

Author: Sujan, Shah Mohammad Asaduzzaman ; Ismail, Mohammad ; Hasan, Md. Ikramul ; Hossain, Mosharof ; Prodhan, Anik ; Quaiyyum, Md. Abdul

In this study, biodiesel was produced from Jatropha (Jatropha curcas) seed oil available in Bangladesh.The percentage of the oil extracted from the seed using a mech. expeller was found at 24.87%.As the free fatty acid content of crude Jatrpha oil was higher, acid-catalyzed esterification and base-catalyzed transesterification were carried out to produce biodiesel.The optimum condition for esterification was found as follows: addition of 90% methanol and 2.25% H₂SO₄ (both are based on the weight% of oil), 60 °C temperature and 90-min reaction time and that for the transesterification was found as follows: addition of 50% methanol and 0.8% NaOH (both are based on the weight of oil), 60 °C temperature and 90-min reaction time.The yield of biodiesel was found 95.09% at optimum condition.The fatty acid content in the produced biodiesel includes oleic acid (45.09%), linoleic acid (25.21%), palmitic acid (13.85%), and Me tricosanoate (10.3%) as a major component.Viscosity, d., pour point, flash point, acid value, and calorific value of the produced biodiesel were found 5.18 cSt, 0.87 gm/cc, -10.01 °C, 96.6 °C, 0.49 mg KOH/g of oil, and 35.84 MJ/Kg, resp.Six blends of biodiesel and com. diesel were prepared and their performances were measured.The produced biodiesel can potentially be used in blending with com. diesel and contribute to the fuel economy of Bangladesh.

01 Apr 2025·PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study

Article

Author: Dyall, Simon C ; Gibson, E Leigh ; Faulkner, Paul

BACKGROUND:

The long-chain omega-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have beneficial effects in depression, and these effects may be mediated via changes in functional brain connectivity. However, little is known about these effects in those with subthreshold depression.

METHODS:

15 Participants aged 18-29 years with Patient Health Questionnaire-8 (PHQ-8) scores ≥ 4 and Generalised Anxiety Disorder Assessment-7 (GAD-7) scores ≥ 5, underwent resting-state functional magnetic resonance imaging. Whole-brain, seed-based connectivity analyses were performed using bilateral orbitofrontal cortex (OFC) and amygdala seeds. Omega-3 and -6 PUFA status was assessed from dried bloodspot analysis of %DHA, %EPA, Omega-3 Index (calculated as the sum of DHA plus EPA expressed as a percentage of the total measured fatty acids and a correction applied as dried blood spot samples were used instead of erythrocytes) and ratio of the omega-6 PUFA arachidonic acid (ARA) to EPA (ARA/EPA).

RESULTS:

PHQ-8 scores indicated subthreshold depression (mean = 10.0; SD = 4.2) and were negatively associated with DHA levels and Omega-3 Index. Significant negative associations were also identified between connectivity of the OFC with the angular gyrus and DHA and Omega-3 Index, while weaker connectivity of these regions was associated with lower PHQ-8 and GAD-7 scores. DHA and Omega-3 Index values were significantly associated with greater connectivity of the amygdala with the posterior cingulate cortex, which was also associated with lower PHQ-8 scores.

CONCLUSIONS:

Higher omega-3 PUFA status in young adults with moderate, but mean subthreshold depression was associated with lower depression rating scores and altered functional connectivity of brain regions shown to play a role in the neurobiology of depression.

01 Mar 2025·JOURNAL OF FOOD ENGINEERING

Preparation of a trans-free fat blend to substitute partially hydrogenated oil

Author: Jin, Qingzhe ; Zhen, Cheng ; Yu, Le ; Zhang, Youfeng ; Yu, Mindi ; Yang, Yujing ; Xing, Zhiqiang ; Liu, Xinrong ; Wang, Xingguo ; Jin, Jun ; Cheng, Zhen

Partially hydrogenated oil (PHO) possesses a mild flavor and exceptional processing characteristics, making it historically the primary choice for creamer.The discovery of health problems of trans fatty acids has accelerated the development of alternative fats.This study aimed to develop an optimal PHO alternative fat by phys. blending.Based on the correlation between physicochem. properties and sensory attributes, soybean oil, fully hydrogenated palm kernel oil, and fully hydrogenated soybean oil (45/45/10, weight/weight/w) were selected to make the alternative fat.The fat blend exhibited a solid fat content (SFC) curve identical to PHO, along with similar melting crystallization behavior, crystal nucleation pattern and growth mode, viscosity (705 mPa s), and taste profile.Pearson correlation anal. was used to further clarify the correlation between properties and tastes.The result showed that the SFCs and fatty acid compositions have strong correlations with tastes.It provides a reference scheme for preparing fats with ideal tastes.

100 Deals associated with Omega-3-Carboxylic Acids

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Omega-3-Carboxylic Acids	C10AX	DB09568

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Hypertriglyceridemia	US	AstraZeneca Pharmaceuticals LP	05 May 2014

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Atherosclerosis	Phase 3	US	AstraZeneca PLC	30 Oct 2014
Atherosclerosis	Phase 3	CN	AstraZeneca PLC	30 Oct 2014
Atherosclerosis	Phase 3	JP	AstraZeneca PLC	30 Oct 2014
Atherosclerosis	Phase 3	AU	AstraZeneca PLC	30 Oct 2014
Atherosclerosis	Phase 3	BE	AstraZeneca PLC	30 Oct 2014
Atherosclerosis	Phase 3	CA	AstraZeneca PLC	30 Oct 2014
Atherosclerosis	Phase 3	CZ	AstraZeneca PLC	30 Oct 2014
Atherosclerosis	Phase 3	DK	AstraZeneca PLC	30 Oct 2014
Atherosclerosis	Phase 3	EE	AstraZeneca PLC	30 Oct 2014
Atherosclerosis	Phase 3	HU	AstraZeneca PLC	30 Oct 2014

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Clinical Result

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01858948 (CTgov)	Phase 3	Metabolic Syndrome \| Bipolar Disorder	19	Placebo+Quetiapine fumarate	jskuwxdyar(orvxvtpuge) = gxpxcokxyl hefscgctmi (wlrqkzjcrz, ecyukxcuda - pxixlcgzbq) View more	-	25 Nov 2022
NCT02104817 (STRENGTH, CTgov)	Phase 3	Hypertriglyceridemia \| Atherosclerosis	13,078	Epanova® (omega-3 carboxylic acids)	bircffxbjj(oslyxqfzwp) = leiczfdtay rcktlaqyxr (jydiswziqc, ecqkqeaigi - czcyhgcqbs) View more	-	28 Jul 2021
NCT02947100 (CTgov)	Phase 1/2	Anemia, Sickle Cell	4	SCD-Omegatex™	dkmjbwrqmq(gqckzddgdz) = djpktqsvwf pmlnfusxti (hkbjhkoiij, wqimfiwxht - elxvtjtyrn) View more	-	19 Oct 2020
NCT02463071 (CTgov)	Phase 3	Hypertriglyceridemia	383	AZD0585 placebo+AZD0585 (AZD0585 2g Group)	dixwvrfqna(ukgpidpyrf) = eckcdaskef szwfyxzypd (okaycfkfzc, tdwhuaghue - esizddoetx) View more	-	01 Oct 2018
				AZD0585 (AZD0585 4g Group)	dixwvrfqna(ukgpidpyrf) = hqqdeijauc szwfyxzypd (okaycfkfzc, puvbofendv - nlyzqhqord) View more
NCT02354976 (CTgov)	Phase 2	Hypertriglyceridemia \| Overweight \| Metabolic dysfunction-associated steatotic liver disease	78	Placebo	bdzkjfyvnr(yqottggymm) = gpcxeohqcp buhzihqwqw (stawvlbggg, kwngsucdof - pqgysrxmuc) View more	-	25 Sep 2018
NCT02057406 (OCEAN, CTgov)	Phase 3	Depressive Disorder \| Heart Failure	108	2:1 EPA/DHA (2:1 EPA/DHA)	fzrxhinefu(orljylxbef) = bzqvequexm mvcmzftqhj (tluuqfxmwx, gfbwdutsoo - gurrjtyfev) View more	-	12 Jun 2017
				High EPA (High EPA)	fzrxhinefu(orljylxbef) = lxqkihpvzl mvcmzftqhj (tluuqfxmwx, mdgkowjuab - meefbrneim) View more
NCT02359045 (CTgov)	Phase 1	-	137	D1400147 (Treatment A_Part 1)	cebjfpcikl(mwjlsjeter) = itqebxpddm flmswfhccb (lhdlrilqub, wfltdwvtjq - etqkkwxsen) View more	-	01 May 2017
				Omega-3-carboxylic acids (Treatment B_Part 1)	cebjfpcikl(mwjlsjeter) = cixxmiiydx flmswfhccb (lhdlrilqub, omqcmzphme - wxegcvoupe) View more
NCT02279407 (EFFECT-II \| EFFECTII, CTgov)	Phase 2	Diabetes Mellitus, Type 2 \| Nonalcoholic Steatohepatitis	223	placebo	kjijlftcoc(wxwjbbrsdo) = fcmpxnvmiy mvpuqhsgno (yvyhnrmkcr, frguxitilk - oupblkqzto) View more	-	27 Jan 2017
NCT02370537 (PRECISE, CTgov)	Phase 2	Diabetes Mellitus, Type 2 \| Exocrine Pancreatic Insufficiency	490	OMACOR+EPANOVA (Low FEC (EPANOVA® and OMACOR®))	adylqbswwo(tuxkavkzcx) = fhgatbukgi keitfbrior (ottjtnpdvu, djgseeymwv - zkvahywxps)	-	20 Jan 2017
				OMACOR+EPANOVA (Intermediate FEC (EPANOVA® and OMACOR®))	adylqbswwo(tuxkavkzcx) = bgycnowawu keitfbrior (ottjtnpdvu, divocqnrbl - vbliqggdas)
NCT02372344 (CTgov)	Phase 1	-	72	AZD0585 (Fasting)	eqlsaeuydx(pmgjwueieb) = wbgfazhihp opegmzjwli (qxlvfvzrtt, bicfmfbbsl - fhtmuggyxk) View more	-	16 May 2016
				AZD0585 (Before Meal)	eqlsaeuydx(pmgjwueieb) = xomcwdkjba opegmzjwli (qxlvfvzrtt, vqbesfxwqz - eodskgzlfo) View more