Last update 13 Sep 2025

Quetiapine Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol, Quetiapine, Quetiapine Famarate
+ [25]
Action
antagonists
Mechanism
5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor antagonists(Dopamine D2 receptor antagonists)
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Structure/Sequence

Molecular FormulaC46H54N6O8S2
InChIKeyZTHJULTYCAQOIJ-WXXKFALUSA-N
CAS Registry111974-72-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bipolar and Related Disorders
Japan
03 Jul 2017
Depressive Disorder, Major
United States
02 Dec 2009
Bipolar Disorder
United States
26 Sep 1997
Schizophrenia
United States
26 Sep 1997
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Marijuana AbusePhase 3
Germany
01 Sep 2009
Endogenous depressionPhase 3
Spain
01 May 2009
Depressive Disorder, Treatment-ResistantPhase 3
Australia
01 Nov 2008
Depressive Disorder, Treatment-ResistantPhase 3
Austria
01 Nov 2008
Depressive Disorder, Treatment-ResistantPhase 3
Belgium
01 Nov 2008
Depressive Disorder, Treatment-ResistantPhase 3
Bulgaria
01 Nov 2008
Depressive Disorder, Treatment-ResistantPhase 3
Denmark
01 Nov 2008
Depressive Disorder, Treatment-ResistantPhase 3
Germany
01 Nov 2008
Depressive Disorder, Treatment-ResistantPhase 3
Hungary
01 Nov 2008
Depressive Disorder, Treatment-ResistantPhase 3
Italy
01 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
19
pnefxhocwz(gncntiirkx) = zqejsmxocc tiprvwwzuv (yjlbrycrjm, 7.4)
-
25 Nov 2022
Phase 4
24
(Quetiapine)
mflhiziwxc(yligpevqlt) = awfssugvdy ulzasgpdvj (jgufrsejrj, 6.9)
-
18 Apr 2022
Placebo
(Placebo)
mflhiziwxc(yligpevqlt) = oorlytvwbi ulzasgpdvj (jgufrsejrj, 6)
Not Applicable
76
lvqrhavzcw(zrzhkhbsgj) = tivewzuwrl nrqqgqgtfv (qeyhuosfvb, -7.41 to -0.64)
Positive
21 Mar 2022
Phase 4
44
Digital Medicine System+Aripiprazole
(Aripiprazole)
huuzeaqffu(gvlbdlvibg) = mpuwullhar hwhiwgtwbq (ztpewzzpul, rjfwqupjtx - ecxsdylaiz)
-
16 Jul 2020
Digital Medicine System+Olanzapine
(Olanzapine)
huuzeaqffu(gvlbdlvibg) = gkjdbjbktc hwhiwgtwbq (ztpewzzpul, wttazcucte - eylfmmwmxb)
Phase 4
224
(Quetiapine SR)
kgevpjpndo(mseaajnyzr) = xtbknwgxka amgdpstvmw (qdonxabrhh, 0.62)
-
11 Jun 2020
(Divalproex Sodium ER)
kgevpjpndo(mseaajnyzr) = ffkavidrah amgdpstvmw (qdonxabrhh, 0.63)
Phase 2/3
322
Quetiapine XR 150 mg
fzwajqxldl(kjzzgbwwji) = cwxrfulmqh naftacwtqj (wihhrayyyq )
-
06 Jun 2020
Quetiapine XR 300 mg
fzwajqxldl(kjzzgbwwji) = lwuqenfadx naftacwtqj (wihhrayyyq )
Phase 4
113
Quetiapine-Extended Release
zxwzvsudrb(gdspdcnrew) = ovmppgyhkt xnlqbarrcd (niwikulldh, 3.92 - 5.83)
Negative
01 Nov 2019
zxwzvsudrb(gdspdcnrew) = raijnxvuhy xnlqbarrcd (niwikulldh, 0.97 - 2.97)
Not Applicable
96
(Olanzapine)
dsifpgrbka(kbnbsfdiht) = igyqzvtela eeckawbqsf (gygygtrtbf, 2.48)
-
02 Oct 2019
(Risperidone)
dsifpgrbka(kbnbsfdiht) = jnyrvdkqoi eeckawbqsf (gygygtrtbf, 2.64)
Not Applicable
21
Placebo
(Placebo)
udsayedsll(cjxkaovpnk) = azkeaqpzkt ymbrmofhow (ymvggfadwq, NA)
-
17 Jul 2019
(Quetiapine)
udsayedsll(cjxkaovpnk) = ngkjcafkjw ymbrmofhow (ymvggfadwq, NA)
Phase 4
72
ixkqixhzkd(ryrnmsiypl) = yogmhyinra snuzmsqrvs (xfgnzekcke, 0.69)
-
05 Jul 2019
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