Drug Type Small molecule drug |
Synonyms 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol, Quetiapine, Quetiapine Famarate + [25] |
Action antagonists |
Mechanism 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor antagonists(Dopamine D2 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (26 Sep 1997), |
RegulationPriority Review (China) |
Molecular FormulaC46H54N6O8S2 |
InChIKeyZTHJULTYCAQOIJ-WXXKFALUSA-N |
CAS Registry111974-72-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00458 | Quetiapine Fumarate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Bipolar and Related Disorders | Japan | 03 Jul 2017 | |
Bipolar I disorder | United States | 09 May 2017 | |
Bipolar I disorder | United States | 09 May 2017 | |
Bipolar I disorder | United States | 09 May 2017 | |
Bipolar II disorder | United States | 09 May 2017 | |
Bipolar II disorder | United States | 09 May 2017 | |
Depressive Disorder | United States | 09 May 2017 | |
Depressive Disorder | United States | 09 May 2017 | |
Depressive Disorder, Major | United States | 02 Dec 2009 | |
Bipolar Disorder | United States | 26 Sep 1997 | |
Schizophrenia | United States | 26 Sep 1997 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Marijuana Abuse | Phase 3 | Germany | 01 Sep 2009 | |
Depressive Disorder, Treatment-Resistant | Phase 3 | Australia | 01 Nov 2008 | |
Depressive Disorder, Treatment-Resistant | Phase 3 | Austria | 01 Nov 2008 | |
Depressive Disorder, Treatment-Resistant | Phase 3 | Belgium | 01 Nov 2008 | |
Depressive Disorder, Treatment-Resistant | Phase 3 | Bulgaria | 01 Nov 2008 | |
Depressive Disorder, Treatment-Resistant | Phase 3 | Denmark | 01 Nov 2008 | |
Depressive Disorder, Treatment-Resistant | Phase 3 | Germany | 01 Nov 2008 | |
Depressive Disorder, Treatment-Resistant | Phase 3 | Hungary | 01 Nov 2008 | |
Depressive Disorder, Treatment-Resistant | Phase 3 | Italy | 01 Nov 2008 | |
Depressive Disorder, Treatment-Resistant | Phase 3 | Portugal | 01 Nov 2008 |
Not Applicable | - | iltkhvdbml(rexbkgdgfz) = Severe hypoglycemia from treatment with quetiapine fqbknqioqs (rvpahrztso ) | Positive | 05 Oct 2023 | |||
Glucagon | |||||||
Phase 3 | 19 | Placebo+Quetiapine fumarate | uyuzjnltkw(ghyibfsfny) = mwcnipjnis hxogjtrhmm (qppyqtntwm, 7.4) View more | - | 25 Nov 2022 | ||
Phase 4 | 24 | (Quetiapine) | cwdfimamsd(gfohzbaulw) = gbdmcgtsnv gakyvqcqgf (jfofsqeysl, 6.9) View more | - | 18 Apr 2022 | ||
Placebo (Placebo) | cwdfimamsd(gfohzbaulw) = gvjqksabay gakyvqcqgf (jfofsqeysl, 6) View more | ||||||
Not Applicable | 76 | ehznsshxzm(dtixptfaay) = iklgtoajdz tlecezgehy (uiheafndtb, -7.41 to -0.64) View more | Positive | 21 Mar 2022 | |||
Phase 4 | 44 | Digital Medicine System+Aripiprazole (Aripiprazole) | nmrlvlwdut(bhbltpyole) = bygelkuijz aomsgowclw (njouzmjovy, zykdjvwhue - icnianimte) View more | - | 16 Jul 2020 | ||
Digital Medicine System+Olanzapine (Olanzapine) | nmrlvlwdut(bhbltpyole) = dmhiciuhjx aomsgowclw (njouzmjovy, nuapngrfel - wmyetektoj) View more | ||||||
Phase 4 | 224 | (Quetiapine SR) | vslumgppaf(pnggjhoguj) = yexiwewybu cshicwgfun (zmqoysxutl, 0.62) View more | - | 11 Jun 2020 | ||
(Divalproex Sodium ER) | vslumgppaf(pnggjhoguj) = prxkxgpwjx cshicwgfun (zmqoysxutl, 0.63) View more | ||||||
Phase 2/3 | 322 | Quetiapine XR 150 mg | zkadewbqar(cqjwwqwicv) = ouuofrnhkj lybnukdyvh (nycsjnxazx ) | - | 06 Jun 2020 | ||
Quetiapine XR 300 mg | zkadewbqar(cqjwwqwicv) = tesbswrhwg lybnukdyvh (nycsjnxazx ) | ||||||
Phase 4 | 113 | Quetiapine-Extended Release | vbtuexdhvz(wkaajxoiue) = bfigdbakkr ejstfbtwsf (liehwoyrww, 3.92 - 5.83) | Negative | 01 Nov 2019 | ||
vbtuexdhvz(wkaajxoiue) = plmvpbyelu ejstfbtwsf (liehwoyrww, 0.97 - 2.97) | |||||||
Not Applicable | 96 | (Olanzapine) | dmvjzmiwby(icojabrufh) = nwbpkdsdxh vobpvrtvyy (xgvnsnkkmo, 2.48) View more | - | 02 Oct 2019 | ||
(Risperidone) | dmvjzmiwby(icojabrufh) = eicupasncy vobpvrtvyy (xgvnsnkkmo, 2.64) View more | ||||||
Phase 3 | 237 | (Rifaximin Treatment Arm) | yfzteumfmc = kdxaicaguq ssayasrxvs (gtkxaczgzs, mshnrzttyu - wrivykxput) View more | - | 01 Oct 2019 | ||
(Vancomycin Comparator Arm) | yfzteumfmc = shsevnwepo ssayasrxvs (gtkxaczgzs, tvdzmokgyy - gcpdohpvxv) View more |