Last update 20 Jul 2024

PLX-51107

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PLX 51107
Target
Mechanism
BRD4 inhibitors(Bromodomain-containing protein 4 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-

Structure

Molecular FormulaC26H22N4O3
InChIKeyAMSUHYUVOVCWTP-INIZCTEOSA-N
CAS Registry1627929-55-8

R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 1
US
01 Mar 2016
Myelodysplastic SyndromesPhase 1
US
01 Mar 2016
Non-Hodgkin LymphomaPhase 1
US
01 Mar 2016
Solid tumorPhase 1
US
01 Mar 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
37
PLX 51107+Azacitidine
pgwkkqpndn(opdmvuyvtl) = non-hema ~ logic ~ xicities: 9 (24%) pts had elevated bilirubin/liver function tests (n=2 Grade 4 and n=7 Grade 3) and n=24 had infections. mrzxamdfsp (xcokdkaknv )
Positive
05 Nov 2021
Phase 1/2
36
jjusyztozl(odgsagkgll) = 17% thictzpanv (hujdicobwo )
-
01 Jun 2018
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Approval

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Regulation

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