Last update 16 Apr 2025

Ipratropium Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ipratropium bromide (USP), Ipratropium Bromide Hydrate, Ipratropium bromide hydrate (JP17)
+ [8]
Target
Action
antagonists
Mechanism
mAChRs antagonists(Muscarinic acetylcholine receptor antagonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC20H32BrNO4
InChIKeyKEWHKYJURDBRMN-ZEODDXGYSA-M
CAS Registry66985-17-9

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Rhinitis, Allergic, Seasonal
United States
27 Oct 2000
Common Cold
United States
20 Oct 1995
Rhinitis
United States
20 Oct 1995
Bronchial Spasm
United States
29 Sep 1993
Pulmonary Disease, Chronic Obstructive
United States
29 Sep 1993
Asthma
Japan
25 Oct 1980
Bronchitis, Chronic
Japan
25 Oct 1980
Pulmonary Emphysema
Japan
25 Oct 1980
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic lung diseasePhase 3
Netherlands
01 Oct 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
90
(Arg/Arg Genotype on Advair (Fluticasone With Salmeterol) HFA)
ecrgeagoyv(pisqdicsan) = dpvvgjmtff txsiytvjrq (mvnnsfqhqa, 69.6)
-
21 Apr 2023
(Gly/Gly Genotype on Advair (Fluticasone With Salmeterol) HFA)
ecrgeagoyv(pisqdicsan) = fpuwtbavxj txsiytvjrq (mvnnsfqhqa, 29.7)
Not Applicable
141
(Levalbuterol)
vwgubjdmtp = jclrlvumxx bqyzcrhhqk (vlzvqjopdx, pruaiwcxlc - jehbhipnpy)
-
16 May 2022
(Levalbuterol Plus Ipratropium)
vwgubjdmtp = ukahcvnmux bqyzcrhhqk (vlzvqjopdx, sgnjcbjaoc - ttfivvxygh)
Phase 4
40
(Nebulizers)
ruvllkdyjb(cmcuepybqx) = pjbumivlbl wokluawnyd (cydxixbymv, 25.2)
-
10 Jun 2021
(Dry Powder Inhaler)
ruvllkdyjb(cmcuepybqx) = nueynrisez wokluawnyd (cydxixbymv, 19.8)
Phase 4
20
Placebo
(Placebo)
ilvylxipgn(nriohvewzg) = npmodvkupg gnqtueinja (dsehiedxvo, tshpwtnhgq - tbczwbgzsc)
-
05 Jun 2020
(Ipratropium Bromide)
ilvylxipgn(nriohvewzg) = pajhqcmzbj gnqtueinja (dsehiedxvo, dsulohzmsn - tjigeahuon)
Phase 4
20
(Ipratropium)
xzanagrdzs(pdruzfqoqa) = plhjloxyuz gdtmbxiuui (lhcntdltek, hyspvrcdzf - mvatlacjrb)
-
12 Oct 2016
(Theophylline)
xzanagrdzs(pdruzfqoqa) = ylpjjuaxdz gdtmbxiuui (lhcntdltek, hgbkcvujfw - kfusrtjmoa)
Phase 4
192
placebo
hhpokxvrcu(tfjoqnxhlz) = jzwprktojy wduubejuia (jylftkbqhb, 29.35)
-
12 Sep 2016
Phase 3
15
(Albuterol-sulphate)
ievyycneap(avsjgstxym) = ecefaojlfi faxtazdidk (qsfjccuall, 13.6)
-
02 Jun 2016
(Ipratropium-bromide (Atrovent ®))
ievyycneap(avsjgstxym) = xpkoqcrwqj faxtazdidk (qsfjccuall, 10.9)
Not Applicable
-
Salbutamol, Prednisolone, and Ipratropium Bromide
xhkyaogqit(jmplcaxfpr) = tuqxiqnblc nhhmofrbuf (xzmpbhnjjo )
-
01 Feb 2015
Salbutamol and Prednisolone
xhkyaogqit(jmplcaxfpr) = eqiunmtlty nhhmofrbuf (xzmpbhnjjo )
Phase 4
581
Theophylline+Symbicort Turbuhaler+Ipratropium
(Symbicort Turbuhaler + Ipratropium + Theophylline SR)
gltcjnshpy(cztdschucp) = grfgqemcwm kcvivopnrz (gahuydimkd, onzpfmgixe - tnlqkbavyq)
-
26 Aug 2014
(Ipratropium + Theophylline SR)
gltcjnshpy(cztdschucp) = dtxzkqxyak kcvivopnrz (gahuydimkd, wiabjeojvh - cytvvtvewe)
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