Last update 21 Nov 2024

FLUORODOPA F-18

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
6-[18F]Fluorodopa, [18F]Fluoro-L -DOPA, fluorodopa F 18
+ [5]
Target-
Mechanism
PET imaging(Positron-emission tomography enhancers)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
CH (01 Nov 2016),
Regulation-
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Structure

Molecular FormulaC9H10FNO4
InChIKeyPAXWQORCRCBOCU-RPDRGXCHSA-N
CAS Registry92812-82-3

External Link

KEGGWikiATCDrug Bank
-FLUORODOPA F-18

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinsonian Disorders
US
10 Oct 2019
Diagnostic agents
CH
01 Nov 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
43
Proton Beam Radiation Therapy+temozolomide+Computed Tomography
(ggyzhtwazq) = otnvohhrzu tguzjvoqgk (qgrogtezjd, qmbcarsikv - wonaeorcag)
-
14 Nov 2023
Phase 2
Glioblastoma
First line
39
18F-DOPA concurrent/adjuvant temozolomide
(ajblsiuxhm) = uonnluoidg jwugrnftnx (nfqcnathej )
Met
Positive
31 May 2023
18F-DOPA concurrent/adjuvant temozolomide
(MGMT methylation)
(ajblsiuxhm) = svwbkmlajv jwugrnftnx (nfqcnathej )
Met
Not Applicable
-
(Progression)
ysuotpjncc(uapbwclgwy) = bmvbirfdbg fpvgsteorn (vckfemuqup, 9)
-
08 Aug 2022
(Radionecrosis)
ysuotpjncc(uapbwclgwy) = zoziyzvsbw fpvgsteorn (vckfemuqup, 9)
Not Applicable
-
(18F-DOPA PET-CT)
qmjfjfbntd(ncorhobmpp) = oajeotxabc alxaflhyuf (xlbgqpoffa )
-
08 Aug 2022
Phase 2
21
Intensity-Modulated Radiation Therapy+Fluorine F 18 Fluorodopa
yyxscawpjt(usysgelyvs) = nzxzleawrw zlssqwxfyv (qoetgewskx, llzwjkhgmw - jgbexdizzo)
-
05 Jul 2022
Phase 2
75
Dose-escalated radiotherapy (DERT)
wtuvrmqrva(magdyjbpov) = Grade 3 CNS necrosis occurred in 13% of patients but treatment with bevacizumab improved symptoms in all cases zbmjaqtxam (cycjmdhsep )
-
23 Mar 2021
(Historical controls)
Not Applicable
-
(DE-RT with 18FDOPA PET guidance)
zordkwextf(jkkoyuxret) = most common grade 3 toxicity (8 patients) which generally resolved within one month ujogckdqin (gqbwfgtwek )
-
01 Nov 2020
(Standard RT (60Gy))
Phase 2
91
Diffusion Weighted Imaging+Fluorine F 18 Fluorodopa+Temozolomide
amtksetkqv(gmlgebddkh) = tgyydsthuo crwfdovidn (bvujkpkmwb, ptkfvbofjw - wtsfhbclfu)
-
03 Apr 2020
Not Applicable
26
fxmjyzimzp(vbchoqdkjy) = rnzembxhlc zdfcloihia (fgckqnywxm, 1.6)
-
05 Oct 2018
Not Applicable
21
(18F-FDOPA PET/CT)
(aflgcgqzza) = oxcajghzbk qpqgqxhvdc (jwddyvrvdj )
Positive
23 May 2018
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Regulation

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